A novel serological test for the diagnosis of central venous catheter-associated sepsis

T. S J Elliott*, S. E. Tebbs, H. A. Moss, T. Worthington, M. K. Spare, M. H. Faroqui, P. A. Lambert

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objectives: To determine the sensitivity and specificity of a novel antibody test for the diagnosis of intravascular catheter-related infections due to coagulase-negative staphylococci. 

Methods: Sixty-seven patients diagnosed as having central venous catheter (CVC)-associated sepsis based on strict clinical criteria, including positive blood cultures, were compared to 67 patients with a CVC in situ who exhibited no evidence of sepsis. An ELISA serological test based on a novel short-chain lipoteichoic acid antigen isolated from coagulase-negative staphylococci (CNS) was used to determine the patient's serological response (IgG and IgM) to CVC sepsis caused by CMS. The specificity and sensitivity of the test was determined. 

Results: There was a significant increase in the antibody levels (IgG and IgM) to the short-chain lipoteichoic acid in patients with CVC-associated staphylococcal sepsis as compared to the control patients. 

Conclusions: This new serological method may offer a useful diagnostic test for intravascular catheter infections caused by staphylococci. 

Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalJournal of Infection
Issue number3
Publication statusPublished - May 2000


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