A peak-clustering method for MEG group analysis to minimise artefacts due to smoothness

Jessica R. Gilbert, Laura R. Shapiro, Gareth R. Barnes

Research output: Contribution to journalArticle

Abstract

Magnetoencephalography (MEG), a non-invasive technique for characterizing brain electrical activity, is gaining popularity as a tool for assessing group-level differences between experimental conditions. One method for assessing task-condition effects involves beamforming, where a weighted sum of field measurements is used to tune activity on a voxel-by-voxel basis. However, this method has been shown to produce inhomogeneous smoothness differences as a function of signal-to-noise across a volumetric image, which can then produce false positives at the group level. Here we describe a novel method for group-level analysis with MEG beamformer images that utilizes the peak locations within each participant's volumetric image to assess group-level effects. We compared our peak-clustering algorithm with SnPM using simulated data. We found that our method was immune to artefactual group effects that can arise as a result of inhomogeneous smoothness differences across a volumetric image. We also used our peak-clustering algorithm on experimental data and found that regions were identified that corresponded with task-related regions identified in the literature. These findings suggest that our technique is a robust method for group-level analysis with MEG beamformer images.
LanguageEnglish
Article numbere45084
Number of pages9
JournalPLoS ONE
Volume7
Issue number9
DOIs
Publication statusPublished - 14 Sep 2012

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Magnetoencephalography
Artifacts
Cluster Analysis
Clustering algorithms
Beamforming
Brain
methodology
Noise
group effect
magnetoencephalography
brain

Bibliographical note

© Gilbert et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cite this

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A peak-clustering method for MEG group analysis to minimise artefacts due to smoothness. / Gilbert, Jessica R.; Shapiro, Laura R.; Barnes, Gareth R.

In: PLoS ONE, Vol. 7, No. 9, e45084, 14.09.2012.

Research output: Contribution to journalArticle

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