We have developed a novel algorithm for integrating source localization and noise suppression based on a probabilistic graphical model of stimulus-evoked MEG/EEG data. Our algorithm localizes multiple dipoles while suppressing noise sources with the computational complexity equivalent to a single dipole scan, and is therefore more efficient than traditional multidipole fitting procedures. In simulation, the algorithm can accurately localize and estimate the time course of several simultaneously-active dipoles, with rotating or fixed orientation, at noise levels typical for averaged MEG data. Furthermore, the algorithm is superior to beamforming techniques, which we show to be an approximation to our graphical model, in estimation of temporally correlated sources. Success of this algorithm for localizing auditory cortex in a tumor patient and for localizing an epileptic spike source are also demonstrated.
|Title of host publication||Advances in Neural Information Processing Systems 19 - Proceedings of the 2006 Conference|
|Number of pages||8|
|Publication status||Published - 1 Dec 2007|
|Event||20th Annual Conference on Neural Information Processing Systems, NIPS 2006 - Vancouver, BC, Canada|
Duration: 4 Dec 2006 → 7 Dec 2006
|Conference||20th Annual Conference on Neural Information Processing Systems, NIPS 2006|
|Period||4/12/06 → 7/12/06|