A protocol for producing the maternal low-protein rat model: A tool for preclinical proteomic studies

Dan Ma; Susan E. Ozanne; Paul C. Guest

doi:10.1007/978-3-319-52479-5_22

A protocol for producing the maternal low-protein rat model: A tool for preclinical proteomic studies

Dan Ma
, Susan E. Ozanne
, Paul C. Guest^*

^*Corresponding author for this work

University of Cambridge
Universidade Estadual de Campinas

Research output: Chapter in Book/Published conference output › Chapter

1 Citation (Scopus)

Abstract

Epidemiological studies have shown that periods of poor nutrition during pregnancy can lead to an increased risk of metabolic and psychiatric disorders in the offspring. In addition, some individuals with disorders such as schizophrenia show signs of impaired insulin signalling. These findings indicate that there may be a link between metabolism and neuronal function and they also provide supporting evidence for neurodevelopmental origins of mental illness. This chapter gives a detailed protocol for generation of the maternal low-protein (LP) rat model, which leads to metabolic disturbances in the offspring. This model has been used in proteomic studies of several disorders including schizophrenia.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Editors	P. Guest
Publisher	Springer
Pages	251-255
Number of pages	5
ISBN (Electronic)	978-3-319-52479-5
ISBN (Print)	978-3-319-52478-8
DOIs	https://doi.org/10.1007/978-3-319-52479-5_22
Publication status	Published - 29 Mar 2017

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	974
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/978-3-319-52479-5_22

https://www.repository.cam.ac.uk/handle/1810/264970

Cite this

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abstract = "Epidemiological studies have shown that periods of poor nutrition during pregnancy can lead to an increased risk of metabolic and psychiatric disorders in the offspring. In addition, some individuals with disorders such as schizophrenia show signs of impaired insulin signalling. These findings indicate that there may be a link between metabolism and neuronal function and they also provide supporting evidence for neurodevelopmental origins of mental illness. This chapter gives a detailed protocol for generation of the maternal low-protein (LP) rat model, which leads to metabolic disturbances in the offspring. This model has been used in proteomic studies of several disorders including schizophrenia.",

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AU - Guest, Paul C.

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Y1 - 2017/3/29

N2 - Epidemiological studies have shown that periods of poor nutrition during pregnancy can lead to an increased risk of metabolic and psychiatric disorders in the offspring. In addition, some individuals with disorders such as schizophrenia show signs of impaired insulin signalling. These findings indicate that there may be a link between metabolism and neuronal function and they also provide supporting evidence for neurodevelopmental origins of mental illness. This chapter gives a detailed protocol for generation of the maternal low-protein (LP) rat model, which leads to metabolic disturbances in the offspring. This model has been used in proteomic studies of several disorders including schizophrenia.

AB - Epidemiological studies have shown that periods of poor nutrition during pregnancy can lead to an increased risk of metabolic and psychiatric disorders in the offspring. In addition, some individuals with disorders such as schizophrenia show signs of impaired insulin signalling. These findings indicate that there may be a link between metabolism and neuronal function and they also provide supporting evidence for neurodevelopmental origins of mental illness. This chapter gives a detailed protocol for generation of the maternal low-protein (LP) rat model, which leads to metabolic disturbances in the offspring. This model has been used in proteomic studies of several disorders including schizophrenia.

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BT - Advances in Experimental Medicine and Biology

A2 - Guest, P.

PB - Springer

ER -

A protocol for producing the maternal low-protein rat model: A tool for preclinical proteomic studies

Abstract

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