A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS

Konstantin Schwarz, Satnam Singh, Satish Kumar Parasuraman, Maggie Bruce, Lee Shepstone, Martin Feelisch, Magdalena Minnion, Shakil Ahmad, John Horowitz, Dana K. Dawson, Michael P. Frenneaux

Research output: Contribution to journalArticle

Abstract

In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.

LanguageEnglish
Pages617-626
Number of pages10
JournalFuture Cardiology
Volume12
Issue number6
Early online date12 Oct 2016
DOIs
Publication statusE-pub ahead of print - 12 Oct 2016

Fingerprint

Stable Angina
Cross-Over Studies
Placebos
Nitrates
Myocardial Ischemia
Myocardium
Skeletal Muscle
Blood Pressure
Therapeutics
Population
sodium nitrate

Keywords

  • angina
  • Inorganic nitrate
  • randomized controlled trial

Cite this

Schwarz, K., Singh, S., Parasuraman, S. K., Bruce, M., Shepstone, L., Feelisch, M., ... Frenneaux, M. P. (2016). A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS. Future Cardiology, 12(6), 617-626. https://doi.org/10.2217/fca-2016-0026
Schwarz, Konstantin ; Singh, Satnam ; Parasuraman, Satish Kumar ; Bruce, Maggie ; Shepstone, Lee ; Feelisch, Martin ; Minnion, Magdalena ; Ahmad, Shakil ; Horowitz, John ; Dawson, Dana K. ; Frenneaux, Michael P. / A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS. In: Future Cardiology. 2016 ; Vol. 12, No. 6. pp. 617-626.
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Schwarz, K, Singh, S, Parasuraman, SK, Bruce, M, Shepstone, L, Feelisch, M, Minnion, M, Ahmad, S, Horowitz, J, Dawson, DK & Frenneaux, MP 2016, 'A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS' Future Cardiology, vol. 12, no. 6, pp. 617-626. https://doi.org/10.2217/fca-2016-0026

A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS. / Schwarz, Konstantin; Singh, Satnam; Parasuraman, Satish Kumar; Bruce, Maggie; Shepstone, Lee; Feelisch, Martin; Minnion, Magdalena; Ahmad, Shakil; Horowitz, John; Dawson, Dana K.; Frenneaux, Michael P.

In: Future Cardiology, Vol. 12, No. 6, 12.10.2016, p. 617-626.

Research output: Contribution to journalArticle

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