A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia

I.D. Maidment, C. Fox, M. Boustani

Research output: Contribution to journalArticle

Abstract

Objective:  To review the literature relating to the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia (PDD).
Method:  MEDLINE (1966 – December 2004), PsychINFO (1972 – December 2004), EMBASE (1980 – December 2004), CINHAL (1982 – December 2004), and the Cochrane Collaboration were searched in December 2004.
Results:  Three controlled trials and seven open studies were identified. Efficacy was assessed in three key domains: cognitive, neuropsychiatric and parkinsonian symptoms.
Conclusion:  Cholinesterase inhibitors have a moderate effect against cognitive symptoms. There is no clear evidence of a noticeable clinical effect against neuropsychiatric symptoms. Tolerability including exacerbation of motor symptoms – in particular tremor – may limit the utility of cholinesterase inhibitors.
Original languageEnglish
Pages (from-to)403-409
Number of pages7
JournalActa Psychiatrica Scandinavica
Volume111
Issue number6
Early online date25 Mar 2005
DOIs
Publication statusPublished - 29 Mar 2005

Keywords

  • aged
  • aged 80 and over
  • cholinesterase inhibitors
  • dementia
  • humans
  • middle aged
  • Parkinson disease
  • randomized controlled trials as topic

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