Abstract
The ageing process results from a complex interplay between genes and the environment that can precipitate an uncontrolled inflammation. Epigenetic changes are believed to provide a link between the environment and nutrition to gene expression by altering the activity of some histone-modifying protein. Epigenetic modifications of DNA and histone proteins have been proposed as important contributory mechanisms to the retention of metabolic memory over time. A thorough understanding of the posttranscriptional and epigenetic factors involved in both normal ageing and age-related disease may inform new strategies and approaches to diagnose, treat, or suppress many aspects of age-dependent frailty.
Original language | English |
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Title of host publication | Immunology of aging |
Editors | Ahmad Massoud, Nima Rezaei |
Place of Publication | Berlin (DE) |
Publisher | Springer |
Pages | 37-45 |
Number of pages | 9 |
ISBN (Electronic) | 978-3-642-39495-9 |
ISBN (Print) | 978-3-642-39494-2 |
DOIs | |
Publication status | Published - 4 Nov 2014 |