A role for epigenetic modulation of the innate immune response during aging

Justin W. Killick, Stuart J. Bennett, Irundika H.K. Dias, Christopher R. Dunston, Helen R. Griffiths*

*Corresponding author for this work

Research output: Chapter in Book/Published conference outputChapter (peer-reviewed)peer-review


The ageing process results from a complex interplay between genes and the environment that can precipitate an uncontrolled inflammation. Epigenetic changes are believed to provide a link between the environment and nutrition to gene expression by altering the activity of some histone-modifying protein. Epigenetic modifications of DNA and histone proteins have been proposed as important contributory mechanisms to the retention of metabolic memory over time. A thorough understanding of the posttranscriptional and epigenetic factors involved in both normal ageing and age-related disease may inform new strategies and approaches to diagnose, treat, or suppress many aspects of age-dependent frailty.

Original languageEnglish
Title of host publicationImmunology of aging
EditorsAhmad Massoud, Nima Rezaei
Place of PublicationBerlin (DE)
Number of pages9
ISBN (Electronic)978-3-642-39495-9
ISBN (Print)978-3-642-39494-2
Publication statusPublished - 4 Nov 2014


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