A role for epigenetic modulation of the innate immune response during aging

Justin W. Killick, Stuart J. Bennett, Irundika H.K. Dias, Christopher R. Dunston, Helen R. Griffiths

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

The ageing process results from a complex interplay between genes and the environment that can precipitate an uncontrolled inflammation. Epigenetic changes are believed to provide a link between the environment and nutrition to gene expression by altering the activity of some histone-modifying protein. Epigenetic modifications of DNA and histone proteins have been proposed as important contributory mechanisms to the retention of metabolic memory over time. A thorough understanding of the posttranscriptional and epigenetic factors involved in both normal ageing and age-related disease may inform new strategies and approaches to diagnose, treat, or suppress many aspects of age-dependent frailty.

Original languageEnglish
Title of host publicationImmunology of aging
EditorsAhmad Massoud, Nima Rezaei
Place of PublicationBerlin (DE)
PublisherSpringer
Pages37-45
Number of pages9
ISBN (Electronic)978-3-642-39495-9
ISBN (Print)978-3-642-39494-2
DOIs
Publication statusPublished - 4 Nov 2014

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Innate Immunity
Epigenomics
Histone Code
Histones
Proteins
Inflammation
Gene Expression
DNA
Genes

Cite this

Killick, J. W., Bennett, S. J., Dias, I. H. K., Dunston, C. R., & Griffiths, H. R. (2014). A role for epigenetic modulation of the innate immune response during aging. In A. Massoud, & N. Rezaei (Eds.), Immunology of aging (pp. 37-45). Berlin (DE): Springer. https://doi.org/10.1007/978-3-642-39495-9_4
Killick, Justin W. ; Bennett, Stuart J. ; Dias, Irundika H.K. ; Dunston, Christopher R. ; Griffiths, Helen R. / A role for epigenetic modulation of the innate immune response during aging. Immunology of aging. editor / Ahmad Massoud ; Nima Rezaei. Berlin (DE) : Springer, 2014. pp. 37-45
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Killick, JW, Bennett, SJ, Dias, IHK, Dunston, CR & Griffiths, HR 2014, A role for epigenetic modulation of the innate immune response during aging. in A Massoud & N Rezaei (eds), Immunology of aging. Springer, Berlin (DE), pp. 37-45. https://doi.org/10.1007/978-3-642-39495-9_4

A role for epigenetic modulation of the innate immune response during aging. / Killick, Justin W.; Bennett, Stuart J.; Dias, Irundika H.K.; Dunston, Christopher R.; Griffiths, Helen R.

Immunology of aging. ed. / Ahmad Massoud; Nima Rezaei. Berlin (DE) : Springer, 2014. p. 37-45.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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Killick JW, Bennett SJ, Dias IHK, Dunston CR, Griffiths HR. A role for epigenetic modulation of the innate immune response during aging. In Massoud A, Rezaei N, editors, Immunology of aging. Berlin (DE): Springer. 2014. p. 37-45 https://doi.org/10.1007/978-3-642-39495-9_4