A role for epigenetic modulation of the innate immune response during aging

Justin W. Killick; Stuart J. Bennett; Irundika H.K. Dias; Christopher R. Dunston; Helen R. Griffiths

doi:10.1007/978-3-642-39495-9_4

A role for epigenetic modulation of the innate immune response during aging

Justin W. Killick, Stuart J. Bennett, Irundika H.K. Dias, Christopher R. Dunston, Helen R. Griffiths^*

^*Corresponding author for this work

Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review

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Abstract

The ageing process results from a complex interplay between genes and the environment that can precipitate an uncontrolled inflammation. Epigenetic changes are believed to provide a link between the environment and nutrition to gene expression by altering the activity of some histone-modifying protein. Epigenetic modifications of DNA and histone proteins have been proposed as important contributory mechanisms to the retention of metabolic memory over time. A thorough understanding of the posttranscriptional and epigenetic factors involved in both normal ageing and age-related disease may inform new strategies and approaches to diagnose, treat, or suppress many aspects of age-dependent frailty.

Original language	English
Title of host publication	Immunology of aging
Editors	Ahmad Massoud, Nima Rezaei
Place of Publication	Berlin (DE)
Publisher	Springer
Pages	37-45
Number of pages	9
ISBN (Electronic)	978-3-642-39495-9
ISBN (Print)	978-3-642-39494-2
DOIs	https://doi.org/10.1007/978-3-642-39495-9_4
Publication status	Published - 4 Nov 2014

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10.1007/978-3-642-39495-9_4

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abstract = "The ageing process results from a complex interplay between genes and the environment that can precipitate an uncontrolled inflammation. Epigenetic changes are believed to provide a link between the environment and nutrition to gene expression by altering the activity of some histone-modifying protein. Epigenetic modifications of DNA and histone proteins have been proposed as important contributory mechanisms to the retention of metabolic memory over time. A thorough understanding of the posttranscriptional and epigenetic factors involved in both normal ageing and age-related disease may inform new strategies and approaches to diagnose, treat, or suppress many aspects of age-dependent frailty.",

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AU - Bennett, Stuart J.

AU - Dias, Irundika H.K.

AU - Dunston, Christopher R.

AU - Griffiths, Helen R.

PY - 2014/11/4

Y1 - 2014/11/4

N2 - The ageing process results from a complex interplay between genes and the environment that can precipitate an uncontrolled inflammation. Epigenetic changes are believed to provide a link between the environment and nutrition to gene expression by altering the activity of some histone-modifying protein. Epigenetic modifications of DNA and histone proteins have been proposed as important contributory mechanisms to the retention of metabolic memory over time. A thorough understanding of the posttranscriptional and epigenetic factors involved in both normal ageing and age-related disease may inform new strategies and approaches to diagnose, treat, or suppress many aspects of age-dependent frailty.

AB - The ageing process results from a complex interplay between genes and the environment that can precipitate an uncontrolled inflammation. Epigenetic changes are believed to provide a link between the environment and nutrition to gene expression by altering the activity of some histone-modifying protein. Epigenetic modifications of DNA and histone proteins have been proposed as important contributory mechanisms to the retention of metabolic memory over time. A thorough understanding of the posttranscriptional and epigenetic factors involved in both normal ageing and age-related disease may inform new strategies and approaches to diagnose, treat, or suppress many aspects of age-dependent frailty.

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BT - Immunology of aging

A2 - Massoud, Ahmad

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ER -

A role for epigenetic modulation of the innate immune response during aging

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