Abstract
METHODS: A total of 106 newborns who had neonatal seizures and were consecutively admitted to the NICU of the University of Parma from January 1999 through December 2004 were prospectively followed-up, and neurologic outcome was assessed at 24 months’ postconceptional age. We conducted a retrospective analysis on this cohort to identify variables that were significantly related to adverse outcome and to develop a scoring system that could provide early prognostic indications.
RESULTS: A total of 70 (66%) of 106 infants had an adverse neurologic outcome. Six variables were identified as the most important independent risk factors for adverse outcome and were used to construct a scoring system: birth weight, Apgar score at 1 minute, neurologic examination at seizure onset, cerebral ultrasound, efficacy of anticonvulsant therapy, and presence of neonatal status epilepticus. Each variable was scored from 0 to 3 to represent the range from “normal” to “severely abnormal.” A total composite score was computed by addition of the raw scores of the 6 variables. This score ranged from 0 to 12. A cutoff score of =4 provided the greatest sensitivity and specificity.
CONCLUSIONS: This scoring system may offer an easy, rapid, and reliable prognostic indicator of neurologic outcome after the onset of neonatal seizures. A final assessment of the validity of this score in routine clinical practice will require independent validation in other centers.
| Language | English |
|---|---|
| Pages | e580-e587 |
| Number of pages | 8 |
| Journal | Pediatrics |
| Volume | 124 |
| Issue number | 4 |
| Early online date | 14 Jun 2009 |
| DOIs | |
| Publication status | Published - Oct 2009 |
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Keywords
- apgar score
- birth weight
- central nervous system diseases
- cohort studies
- developmental disabilities
- electroencephalography
- female
- humans
- newborn
- infant
- premature infant
- neonatal intensive care units
- logistic models
- male
- mental disorders
- multivariate analysis
- neurologic examination
- probability
- prognosis
- prospective studies
- registries
- risk assessment
- seizures
- severity of illness index
- status epilepticus
- time factors
- transcranial doppler ultrasonography
- neonatal seizures
- neurodevelopmental outcome
- preterm infants
Cite this
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A scoring system for early prognostic assessment after neonatal seizures. / Pisani, Francesco; Pisani, Francesco; Sisti, Lisa; Seri, Stefano.
In: Pediatrics, Vol. 124, No. 4, 10.2009, p. e580-e587.Research output: Contribution to journal › Article
TY - JOUR
T1 - A scoring system for early prognostic assessment after neonatal seizures
AU - Pisani, Francesco
AU - Pisani, Francesco
AU - Sisti, Lisa
AU - Seri, Stefano
PY - 2009/10
Y1 - 2009/10
N2 - OBJECTIVE: The aim of this study was to devise a scoring system that could aid in predicting neurologic outcome at the onset of neonatal seizures. METHODS: A total of 106 newborns who had neonatal seizures and were consecutively admitted to the NICU of the University of Parma from January 1999 through December 2004 were prospectively followed-up, and neurologic outcome was assessed at 24 months’ postconceptional age. We conducted a retrospective analysis on this cohort to identify variables that were significantly related to adverse outcome and to develop a scoring system that could provide early prognostic indications. RESULTS: A total of 70 (66%) of 106 infants had an adverse neurologic outcome. Six variables were identified as the most important independent risk factors for adverse outcome and were used to construct a scoring system: birth weight, Apgar score at 1 minute, neurologic examination at seizure onset, cerebral ultrasound, efficacy of anticonvulsant therapy, and presence of neonatal status epilepticus. Each variable was scored from 0 to 3 to represent the range from “normal” to “severely abnormal.” A total composite score was computed by addition of the raw scores of the 6 variables. This score ranged from 0 to 12. A cutoff score of =4 provided the greatest sensitivity and specificity. CONCLUSIONS: This scoring system may offer an easy, rapid, and reliable prognostic indicator of neurologic outcome after the onset of neonatal seizures. A final assessment of the validity of this score in routine clinical practice will require independent validation in other centers.
AB - OBJECTIVE: The aim of this study was to devise a scoring system that could aid in predicting neurologic outcome at the onset of neonatal seizures. METHODS: A total of 106 newborns who had neonatal seizures and were consecutively admitted to the NICU of the University of Parma from January 1999 through December 2004 were prospectively followed-up, and neurologic outcome was assessed at 24 months’ postconceptional age. We conducted a retrospective analysis on this cohort to identify variables that were significantly related to adverse outcome and to develop a scoring system that could provide early prognostic indications. RESULTS: A total of 70 (66%) of 106 infants had an adverse neurologic outcome. Six variables were identified as the most important independent risk factors for adverse outcome and were used to construct a scoring system: birth weight, Apgar score at 1 minute, neurologic examination at seizure onset, cerebral ultrasound, efficacy of anticonvulsant therapy, and presence of neonatal status epilepticus. Each variable was scored from 0 to 3 to represent the range from “normal” to “severely abnormal.” A total composite score was computed by addition of the raw scores of the 6 variables. This score ranged from 0 to 12. A cutoff score of =4 provided the greatest sensitivity and specificity. CONCLUSIONS: This scoring system may offer an easy, rapid, and reliable prognostic indicator of neurologic outcome after the onset of neonatal seizures. A final assessment of the validity of this score in routine clinical practice will require independent validation in other centers.
KW - apgar score
KW - birth weight
KW - central nervous system diseases
KW - cohort studies
KW - developmental disabilities
KW - electroencephalography
KW - female
KW - humans
KW - newborn
KW - infant
KW - premature infant
KW - neonatal intensive care units
KW - logistic models
KW - male
KW - mental disorders
KW - multivariate analysis
KW - neurologic examination
KW - probability
KW - prognosis
KW - prospective studies
KW - registries
KW - risk assessment
KW - seizures
KW - severity of illness index
KW - status epilepticus
KW - time factors
KW - transcranial doppler ultrasonography
KW - neonatal seizures
KW - neurodevelopmental outcome
KW - preterm infants
UR - http://www.scopus.com/inward/record.url?scp=70349741042&partnerID=8YFLogxK
UR - http://pediatrics.aappublications.org/content/124/4/e580
U2 - 10.1542/peds.2008-2087
DO - 10.1542/peds.2008-2087
M3 - Article
VL - 124
SP - e580-e587
JO - Pediatrics
T2 - Pediatrics
JF - Pediatrics
SN - 0031-4005
IS - 4
ER -