A simple and efficient procedure for Knoevenagel reaction promoted by imidazolium-based ionic liquids

Xiaomei Hu; Conelius Ngwa; Qinguo Zheng

doi:10.2174/1570179412666150505185134

A simple and efficient procedure for Knoevenagel reaction promoted by imidazolium-based ionic liquids

Xiaomei Hu, Conelius Ngwa, Qinguo Zheng^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Various room temperature ionic liquids (RTILs), notably, 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]ˉ , have been used to promote the Knoevenagel condensation to afford substituted olefins. All reactions proceeded effectively in the absence of any other catalysts or co-solvents with good to excellent yields. This method is simple and applicable to reactions involving a wide range of aldehydes and ketones with methylene compounds. The ionic liquid can be recycled without noticeable reduction of its catalytic activity. A plausible reaction mechanism is proposed.

Original language	English
Pages (from-to)	101-110
Number of pages	10
Journal	Current Organic Synthesis
Volume	13
Issue number	1
DOIs	https://doi.org/10.2174/1570179412666150505185134
Publication status	Published - 2016

Bibliographical note

The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1570179412666150505185134

Keywords

Carbonyl compounds
Catalysis
Ionic liquids
Knoevenagel condensation
Olefins

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10.2174/1570179412666150505185134

Knoevenagel reaction promoted by imidazolium-based ionic liquids
The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1570179412666150505185134
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title = "A simple and efficient procedure for Knoevenagel reaction promoted by imidazolium-based ionic liquids",

abstract = "Various room temperature ionic liquids (RTILs), notably, 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]ˉ , have been used to promote the Knoevenagel condensation to afford substituted olefins. All reactions proceeded effectively in the absence of any other catalysts or co-solvents with good to excellent yields. This method is simple and applicable to reactions involving a wide range of aldehydes and ketones with methylene compounds. The ionic liquid can be recycled without noticeable reduction of its catalytic activity. A plausible reaction mechanism is proposed.",

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author = "Xiaomei Hu and Conelius Ngwa and Qinguo Zheng",

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T1 - A simple and efficient procedure for Knoevenagel reaction promoted by imidazolium-based ionic liquids

AU - Hu, Xiaomei

AU - Ngwa, Conelius

AU - Zheng, Qinguo

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N2 - Various room temperature ionic liquids (RTILs), notably, 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]ˉ , have been used to promote the Knoevenagel condensation to afford substituted olefins. All reactions proceeded effectively in the absence of any other catalysts or co-solvents with good to excellent yields. This method is simple and applicable to reactions involving a wide range of aldehydes and ketones with methylene compounds. The ionic liquid can be recycled without noticeable reduction of its catalytic activity. A plausible reaction mechanism is proposed.

AB - Various room temperature ionic liquids (RTILs), notably, 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]ˉ , have been used to promote the Knoevenagel condensation to afford substituted olefins. All reactions proceeded effectively in the absence of any other catalysts or co-solvents with good to excellent yields. This method is simple and applicable to reactions involving a wide range of aldehydes and ketones with methylene compounds. The ionic liquid can be recycled without noticeable reduction of its catalytic activity. A plausible reaction mechanism is proposed.

KW - Carbonyl compounds

KW - Catalysis

KW - Ionic liquids

KW - Knoevenagel condensation

KW - Olefins

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A simple and efficient procedure for Knoevenagel reaction promoted by imidazolium-based ionic liquids

Abstract

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Keywords

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