A simple and efficient procedure for Knoevenagel reaction promoted by imidazolium-based ionic liquids

Xiaomei Hu, Conelius Ngwa, Qinguo Zheng*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Various room temperature ionic liquids (RTILs), notably, 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]ˉ , have been used to promote the Knoevenagel condensation to afford substituted olefins. All reactions proceeded effectively in the absence of any other catalysts or co-solvents with good to excellent yields. This method is simple and applicable to reactions involving a wide range of aldehydes and ketones with methylene compounds. The ionic liquid can be recycled without noticeable reduction of its catalytic activity. A plausible reaction mechanism is proposed.
Original languageEnglish
Pages (from-to)101-110
Number of pages10
JournalCurrent Organic Synthesis
Volume13
Issue number1
DOIs
Publication statusPublished - 2016

Bibliographical note

The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1570179412666150505185134

Keywords

  • Carbonyl compounds
  • Catalysis
  • Ionic liquids
  • Knoevenagel condensation
  • Olefins

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