A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation

Michael Schellenberger Costa*, Arne Weigenand, Hong Viet V. Ngo, Lisa Marshall, Jan Born, Thomas Martinetz, Jens Christian Claussen

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Few models exist that accurately reproduce the complex rhythms of the thalamocortical system that are apparent in measured scalp EEG and at the same time, are suitable for large-scale simulations of brain activity. Here, we present a neural mass model of the thalamocortical system during natural non-REM sleep, which is able to generate fast sleep spindles (12–15 Hz), slow oscillations (<1 Hz) and K-complexes, as well as their distinct temporal relations, and response to auditory stimuli. We show that with the inclusion of detailed calcium currents, the thalamic neural mass model is able to generate different firing modes, and validate the model with EEG-data from a recent sleep study in humans, where closed-loop auditory stimulation was applied. The model output relates directly to the EEG, which makes it a useful basis to develop new stimulation protocols.

Original languageEnglish
Article numbere1005022
JournalPLoS computational biology
Volume12
Issue number9
DOIs
Publication statusPublished - 1 Sep 2016

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Acoustic Stimulation
sleep
Sleep
Electroencephalography
Scalp
Model
Calcium
Closed-loop
Brain
oscillation
brain
Inclusion
calcium
Electroencephalogram
Oscillation
Distinct
Output
simulation
Simulation

Bibliographical note

© 2016 Schellenberger Costa et al. This
is an open access article distributed under the terms
of the Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.

Cite this

Schellenberger Costa, M., Weigenand, A., Ngo, H. V. V., Marshall, L., Born, J., Martinetz, T., & Claussen, J. C. (2016). A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation. PLoS computational biology, 12(9), [e1005022]. https://doi.org/10.1371/journal.pcbi.1005022
Schellenberger Costa, Michael ; Weigenand, Arne ; Ngo, Hong Viet V. ; Marshall, Lisa ; Born, Jan ; Martinetz, Thomas ; Claussen, Jens Christian. / A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation. In: PLoS computational biology. 2016 ; Vol. 12, No. 9.
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Schellenberger Costa, M, Weigenand, A, Ngo, HVV, Marshall, L, Born, J, Martinetz, T & Claussen, JC 2016, 'A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation', PLoS computational biology, vol. 12, no. 9, e1005022. https://doi.org/10.1371/journal.pcbi.1005022

A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation. / Schellenberger Costa, Michael; Weigenand, Arne; Ngo, Hong Viet V.; Marshall, Lisa; Born, Jan; Martinetz, Thomas; Claussen, Jens Christian.

In: PLoS computational biology, Vol. 12, No. 9, e1005022, 01.09.2016.

Research output: Contribution to journalArticle

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Schellenberger Costa M, Weigenand A, Ngo HVV, Marshall L, Born J, Martinetz T et al. A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation. PLoS computational biology. 2016 Sep 1;12(9). e1005022. https://doi.org/10.1371/journal.pcbi.1005022