Acute and long-term effects of peroxisome proliferator-activated receptor-γ activation on the function and insulin secretory responsiveness of clonal beta-cells

N. Irwin, J.M. McKinney, C.J. Bailey, N.H. McClenaghan, P.R. Flatt

Research output: Contribution to journalArticle

Abstract

Thiazolidinediones (TZDs) are used as antidiabetic therapy. The purpose of the present study was to examine whether the TZD rosiglitazone has direct actions on pancreatic beta-cells that contribute to its overall effects. Effects of acute and prolonged (48 h) exposure to rosiglitazone, as a model glitazone compound, were assessed in clonal pancreatic BRIN-BD11 beta-cells maintained in standard, glucotoxic and lipotoxic cultures. In acute 20-min incubations, rosiglitazone (0.2-100 M) did not alter basal or glucose-stimulated insulin secretion. However, rosiglitazone (6.25 M) enhanced (p
Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalHormone and Metabolic Research
Volume43
Issue number4
DOIs
Publication statusPublished - Apr 2011

Keywords

  • insulin secretion
  • rosiglitazone
  • beta-cell
  • AMPK
  • PPAR-γ

Fingerprint Dive into the research topics of 'Acute and long-term effects of peroxisome proliferator-activated receptor-γ activation on the function and insulin secretory responsiveness of clonal beta-cells'. Together they form a unique fingerprint.

  • Cite this