Acute anterior uveitis, ankylosing spondylitis, back pain, and HLA-B27

Adrian B. Beckingsale, Jonathan Davies, Jonathan M. Gibson, A. Ralph Rosenthal

Research output: Contribution to journalArticlepeer-review


One hundred and sixty-nine patients with acute anterior uveitis were studied for the presence of HLA-B27 tissue type, radiological evidence of ankylosing spondylitis, and a history of back pain. 60% were male; 45% were HLA-B27+. The male:female ratio in the HLA-B27+ group was the same as in the whole group. 24% had radiological evidence of ankylosing spondylitis, and, of these, 83% were HLA-B27+ while 17% were HLA-B27-. There was a definite correlation between the severity of the ankylosing spondylitis and preponderance of males in the HLA-B27+ group of patients. Significant back pain occurred in 60% of HLA-B27+ patients but in only 14% of HLA-B27- patients. The importance of the selection of patients and of consistency in the use of diagnostic criteria in studies relating to ankylosing spondylitis and acute anterior uveitis is stressed.
Original languageEnglish
Pages (from-to)741-745
Number of pages5
JournalBritish Journal of Ophthalmology
Issue number10
Publication statusPublished - Oct 1984


  • Acute Disease
  • Back Pain
  • Female
  • HLA Antigens
  • HLA-B27 Antigen
  • Humans
  • Male
  • Sacroiliac Joint
  • Sex Factors
  • Spondylitis, Ankylosing
  • Uveitis, Anterior


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