Adaptive responses of the embryo to maternal diet and consequences for post-implantation development

Tom P. Fleming, Emma S. Lucas, Adam J. Watkins, Judith J. Eckert

Research output: Contribution to journalArticle

Abstract

Maternal periconceptional (PC) nutrition, coupled with maternal physiological condition, can impact on reproductive performance and potential across mammalian species. Oocyte quality and embryo development are affected adversely by either nutrient restriction or excess. Moreover, the quality of maternal PC nutrition can have lasting effects through fetal development and postnatally into adulthood. Chronic disease, notably cardiovascular and metabolic disease, and abnormal behaviour have been identified in adult offspring in small and large animal models of PC nutrient restriction. These long-term effects associate with compensatory responses that begin from the time of early embryo development. This review assesses the field of PC nutrition in vivo on short- and long-term developmental consequences in rodent and ruminant models and considers the implications for human health.
Original languageEnglish
Pages (from-to)35-44
Number of pages10
JournalReproduction, fertility and development
Volume24
Issue number1
DOIs
Publication statusPublished - 6 Dec 2011

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maternal nutrition
embryo (animal)
embryogenesis
Embryonic Structures
Mothers
Diet
abnormal behavior
Embryonic Development
nutrients
fetal development
metabolic diseases
adulthood
chronic diseases
cardiovascular diseases
human health
long term effects
Food
ruminants
reproductive performance
oocytes

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Fleming, Tom P. ; Lucas, Emma S. ; Watkins, Adam J. ; Eckert, Judith J. / Adaptive responses of the embryo to maternal diet and consequences for post-implantation development. In: Reproduction, fertility and development. 2011 ; Vol. 24, No. 1. pp. 35-44.
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Adaptive responses of the embryo to maternal diet and consequences for post-implantation development. / Fleming, Tom P.; Lucas, Emma S.; Watkins, Adam J.; Eckert, Judith J.

In: Reproduction, fertility and development, Vol. 24, No. 1, 06.12.2011, p. 35-44.

Research output: Contribution to journalArticle

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