Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Veemal Bhowruth; David E. Minnikin; Else Marie Agger; Peter Andersen; Vincent W. Bramwell; Yvonne Perrie; Gurdyal S. Besra

doi:10.1016/j.bmcl.2009.02.027

Adjuvant properties of a simplified C₃₂ monomycolyl glycerol analogue

Veemal Bhowruth, David E. Minnikin, Else Marie Agger, Peter Andersen, Vincent W. Bramwell, Yvonne Perrie, Gurdyal S. Besra

Research output: Contribution to journal › Article › peer-review

Abstract

A simplified C_³² monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C_³² MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

Original language	English
Pages (from-to)	2029-2032
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	7
Early online date	11 Feb 2009
DOIs	https://doi.org/10.1016/j.bmcl.2009.02.027
Publication status	Published - 1 Apr 2009

Keywords

immunologic adjuvants
animals
glycerol
interferon-gamma
interleukin-6
mice
inbred BALB C mice
quaternary ammonium compounds
up-regulation
vaccination

Access to Document

10.1016/j.bmcl.2009.02.027

Cite this

@article{2f020c83b89c4939a69c917515515d72,

title = "Adjuvant properties of a simplified C32 monomycolyl glycerol analogue",

abstract = "A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).",

keywords = "immunologic adjuvants, animals, glycerol, interferon-gamma, interleukin-6, mice, inbred BALB C mice, quaternary ammonium compounds, up-regulation, vaccination",

author = "Veemal Bhowruth and Minnikin, {David E.} and Agger, {Else Marie} and Peter Andersen and Bramwell, {Vincent W.} and Yvonne Perrie and Besra, {Gurdyal S.}",

year = "2009",

month = apr,

day = "1",

doi = "10.1016/j.bmcl.2009.02.027",

language = "English",

volume = "19",

pages = "2029--2032",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

number = "7",

}

TY - JOUR

T1 - Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

AU - Bhowruth, Veemal

AU - Minnikin, David E.

AU - Agger, Else Marie

AU - Andersen, Peter

AU - Bramwell, Vincent W.

AU - Perrie, Yvonne

AU - Besra, Gurdyal S.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

AB - A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

KW - immunologic adjuvants

KW - animals

KW - glycerol

KW - interferon-gamma

KW - interleukin-6

KW - mice

KW - inbred BALB C mice

KW - quaternary ammonium compounds

KW - up-regulation

KW - vaccination

UR - http://www.scopus.com/inward/record.url?scp=61849102445&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2009.02.027

DO - 10.1016/j.bmcl.2009.02.027

M3 - Article

C2 - 19251417

SN - 0960-894X

VL - 19

SP - 2029

EP - 2032

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Adjuvant properties of a simplified C₃₂ monomycolyl glycerol analogue

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this