Abstract
A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).
Original language | English |
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Pages (from-to) | 2029-2032 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 19 |
Issue number | 7 |
Early online date | 11 Feb 2009 |
DOIs | |
Publication status | Published - 1 Apr 2009 |
Keywords
- immunologic adjuvants
- animals
- glycerol
- interferon-gamma
- interleukin-6
- mice
- inbred BALB C mice
- quaternary ammonium compounds
- up-regulation
- vaccination