Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Veemal Bhowruth, David E. Minnikin, Else Marie Agger, Peter Andersen, Vincent W. Bramwell, Yvonne Perrie, Gurdyal S. Besra

Research output: Contribution to journalArticle

Abstract

A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

LanguageEnglish
Pages2029-2032
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number7
Early online date11 Feb 2009
DOIs
Publication statusPublished - 1 Apr 2009

Fingerprint

Glycerol
Trehalose
Interleukin-6
Spleen
ammonium bromide

Keywords

  • immunologic adjuvants
  • animals
  • glycerol
  • interferon-gamma
  • interleukin-6
  • mice
  • inbred BALB C mice
  • quaternary ammonium compounds
  • up-regulation
  • vaccination

Cite this

Bhowruth, V., Minnikin, D. E., Agger, E. M., Andersen, P., Bramwell, V. W., Perrie, Y., & Besra, G. S. (2009). Adjuvant properties of a simplified C32 monomycolyl glycerol analogue. Bioorganic and Medicinal Chemistry Letters, 19(7), 2029-2032. https://doi.org/10.1016/j.bmcl.2009.02.027
Bhowruth, Veemal ; Minnikin, David E. ; Agger, Else Marie ; Andersen, Peter ; Bramwell, Vincent W. ; Perrie, Yvonne ; Besra, Gurdyal S. / Adjuvant properties of a simplified C32 monomycolyl glycerol analogue. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 7. pp. 2029-2032.
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Bhowruth, V, Minnikin, DE, Agger, EM, Andersen, P, Bramwell, VW, Perrie, Y & Besra, GS 2009, 'Adjuvant properties of a simplified C32 monomycolyl glycerol analogue' Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 7, pp. 2029-2032. https://doi.org/10.1016/j.bmcl.2009.02.027

Adjuvant properties of a simplified C32 monomycolyl glycerol analogue. / Bhowruth, Veemal; Minnikin, David E.; Agger, Else Marie; Andersen, Peter; Bramwell, Vincent W.; Perrie, Yvonne; Besra, Gurdyal S.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 7, 01.04.2009, p. 2029-2032.

Research output: Contribution to journalArticle

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AU - Perrie, Yvonne

AU - Besra, Gurdyal S.

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KW - glycerol

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KW - interleukin-6

KW - mice

KW - inbred BALB C mice

KW - quaternary ammonium compounds

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Bhowruth V, Minnikin DE, Agger EM, Andersen P, Bramwell VW, Perrie Y et al. Adjuvant properties of a simplified C32 monomycolyl glycerol analogue. Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):2029-2032. https://doi.org/10.1016/j.bmcl.2009.02.027