Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Veemal Bhowruth, David E. Minnikin, Else Marie Agger, Peter Andersen, Vincent W. Bramwell, Yvonne Perrie, Gurdyal S. Besra

Research output: Contribution to journalArticlepeer-review

Abstract

A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

Original languageEnglish
Pages (from-to)2029-2032
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number7
Early online date11 Feb 2009
DOIs
Publication statusPublished - 1 Apr 2009

Keywords

  • immunologic adjuvants
  • animals
  • glycerol
  • interferon-gamma
  • interleukin-6
  • mice
  • inbred BALB C mice
  • quaternary ammonium compounds
  • up-regulation
  • vaccination

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