Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Veemal Bhowruth; David E. Minnikin; Else Marie Agger; Peter Andersen; Vincent W. Bramwell; Yvonne Perrie; Gurdyal S. Besra

doi:10.1016/j.bmcl.2009.02.027

Adjuvant properties of a simplified C₃₂ monomycolyl glycerol analogue

Veemal Bhowruth
, David E. Minnikin
, Else Marie Agger
, Peter Andersen
, Vincent W. Bramwell
, Yvonne Perrie
, Gurdyal S. Besra

University College Birmingham
Statens Serum Institut

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A simplified C_³² monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C_³² MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

Original language	English
Pages (from-to)	2029-2032
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	7
Early online date	11 Feb 2009
DOIs	https://doi.org/10.1016/j.bmcl.2009.02.027
Publication status	Published - 1 Apr 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

immunologic adjuvants
animals
glycerol
interferon-gamma
interleukin-6
mice
inbred BALB C mice
quaternary ammonium compounds
up-regulation
vaccination

Access to Document

10.1016/j.bmcl.2009.02.027

Cite this

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abstract = "A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).",

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AU - Bhowruth, Veemal

AU - Minnikin, David E.

AU - Agger, Else Marie

AU - Andersen, Peter

AU - Bramwell, Vincent W.

AU - Perrie, Yvonne

AU - Besra, Gurdyal S.

PY - 2009/4/1

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AB - A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

KW - immunologic adjuvants

KW - animals

KW - glycerol

KW - interferon-gamma

KW - interleukin-6

KW - mice

KW - inbred BALB C mice

KW - quaternary ammonium compounds

KW - up-regulation

KW - vaccination

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EP - 2032

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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