Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Veemal Bhowruth; David E. Minnikin; Else Marie Agger; Peter Andersen; Vincent W. Bramwell; Yvonne Perrie; Gurdyal S. Besra

doi:10.1016/j.bmcl.2009.02.027

Adjuvant properties of a simplified C₃₂ monomycolyl glycerol analogue

Veemal Bhowruth, David E. Minnikin, Else Marie Agger, Peter Andersen, Vincent W. Bramwell, Yvonne Perrie, Gurdyal S. Besra

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A simplified C_³² monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C_³² MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

Original language	English
Pages (from-to)	2029-2032
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	7
Early online date	11 Feb 2009
DOIs	https://doi.org/10.1016/j.bmcl.2009.02.027
Publication status	Published - 1 Apr 2009

Keywords

immunologic adjuvants
animals
glycerol
interferon-gamma
interleukin-6
mice
inbred BALB C mice
quaternary ammonium compounds
up-regulation
vaccination

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10.1016/j.bmcl.2009.02.027

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abstract = "A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).",

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AU - Bhowruth, Veemal

AU - Minnikin, David E.

AU - Agger, Else Marie

AU - Andersen, Peter

AU - Bramwell, Vincent W.

AU - Perrie, Yvonne

AU - Besra, Gurdyal S.

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AB - A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

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KW - animals

KW - glycerol

KW - interferon-gamma

KW - interleukin-6

KW - mice

KW - inbred BALB C mice

KW - quaternary ammonium compounds

KW - up-regulation

KW - vaccination

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JO - Bioorganic and Medicinal Chemistry Letters

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Adjuvant properties of a simplified C₃₂ monomycolyl glycerol analogue

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Keywords

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