Administration of growth factors for bone regeneration

Ye-Rang Yun, Jun Hyeog Jang, Eunyi Jeon, Wonmo Kang, Sujin Lee, Jong-Eun Won, Hae Won Kim, Ivan Wall

Research output: Contribution to journalReview article

Abstract

Growth factors (GFs) such as BMPs, FGFs, VEGFs and IGFs have significant impacts on osteoblast behavior, and thus have been widely utilized for bone tissue regeneration. Recently, securing biological stability for a sustainable and controllable release to the target tissue has been a challenge to practical applications. This challenge has been addressed to some degree with the development of appropriate carrier materials and delivery systems. This review highlights the importance and roles of those GFs, as well as their proper administration for targeting bone regeneration. Additionally, the in vitro and in vivo performance of those GFs with or without the use of carrier systems in the repair and regeneration of bone tissue is systematically addressed. Moreover, some recent advances in the utility of the GFs, such as using fusion technology, are also reviewed.

Original languageEnglish
Pages (from-to)369-85
Number of pages17
JournalRegenerative medicine
Volume7
Issue number3
DOIs
Publication statusPublished - May 2012

Fingerprint

Bone Regeneration
Intercellular Signaling Peptides and Proteins
Bone
Vascular Endothelial Growth Factors
Tissue
Bone and Bones
Tissue regeneration
Osteoblasts
Regeneration
Repair
Fusion reactions
Technology

Bibliographical note

© 2019 Future Science Group.

Keywords

  • Animals
  • Bone Regeneration/drug effects
  • Drug Carriers/chemistry
  • Drug Delivery Systems/methods
  • Drug and Narcotic Control
  • Humans
  • Intercellular Signaling Peptides and Proteins/administration & dosage
  • Translational Medical Research/legislation & jurisprudence

Cite this

Yun, Y-R., Jang, J. H., Jeon, E., Kang, W., Lee, S., Won, J-E., ... Wall, I. (2012). Administration of growth factors for bone regeneration. Regenerative medicine, 7(3), 369-85. https://doi.org/10.2217/rme.12.1
Yun, Ye-Rang ; Jang, Jun Hyeog ; Jeon, Eunyi ; Kang, Wonmo ; Lee, Sujin ; Won, Jong-Eun ; Kim, Hae Won ; Wall, Ivan. / Administration of growth factors for bone regeneration. In: Regenerative medicine. 2012 ; Vol. 7, No. 3. pp. 369-85.
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Yun, Y-R, Jang, JH, Jeon, E, Kang, W, Lee, S, Won, J-E, Kim, HW & Wall, I 2012, 'Administration of growth factors for bone regeneration', Regenerative medicine, vol. 7, no. 3, pp. 369-85. https://doi.org/10.2217/rme.12.1

Administration of growth factors for bone regeneration. / Yun, Ye-Rang; Jang, Jun Hyeog; Jeon, Eunyi; Kang, Wonmo; Lee, Sujin; Won, Jong-Eun; Kim, Hae Won; Wall, Ivan.

In: Regenerative medicine, Vol. 7, No. 3, 05.2012, p. 369-85.

Research output: Contribution to journalReview article

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AU - Yun, Ye-Rang

AU - Jang, Jun Hyeog

AU - Jeon, Eunyi

AU - Kang, Wonmo

AU - Lee, Sujin

AU - Won, Jong-Eun

AU - Kim, Hae Won

AU - Wall, Ivan

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Yun Y-R, Jang JH, Jeon E, Kang W, Lee S, Won J-E et al. Administration of growth factors for bone regeneration. Regenerative medicine. 2012 May;7(3):369-85. https://doi.org/10.2217/rme.12.1