Adrenomedullin: receptor and signal transduction

David M. Smith, H.A. Coppock, D.J. Withers, A.A. Owji, D.L. Hay, T.P. Choksi, P. Chakravarty, S. Legon, David R. Poyner

Research output: Contribution to journalArticle

Abstract

Adrenomedullin is a vascular tissue peptide and a member of the calcitonin family of peptides, which includes calcitonin calcitonin-gene-related peptide (CGRP) and amylin. Its many biological actions are mediated via CGRP type 1 (CGRP(1)) receptors and by specific adrenomedullin receptors. Although the pharmacology of these receptors is distinct, they are both represented in molecular terms by the type II family G-protein-coupled receptor, calcitonin-receptor-like receptor (CRLR). The specificity here is defined by co-expression of receptor-activity-modifying proteins (RAMPs). CGRP(1) receptors are represented by CRLR and RAMP1, and specific adrenomedullin receptors by CRLR and RAMP2 or 3. Here we discuss how CRLR/RAMP2 relates to adrenomedullin binding, pharmacology and pathophysiology, and how chemical cross-linking of receptor-ligand complexes in tissue relates to that in CRLR/RAMP2-expressing cells. CRLR, like other type II family G-protein-coupled receptors, signals via G(s) and adenylate cyclase activation. We demonstrated that adrenomedullin signalling in cell lines expressing specific adrenomedullin receptors followed this expected pattern.
Original languageEnglish
Pages (from-to)432-437
Number of pages6
JournalBiochemical Society Transactions
Volume30
Issue number4
DOIs
Publication statusPublished - 28 Aug 2002

Keywords

  • calcitonin
  • calcitonin-receptor-like receptor
  • CRLR
  • receptor-activity-modifying protein
  • RAMP
  • type II G-protein-coupled receptor
  • GPCR

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    Smith, D. M., Coppock, H. A., Withers, D. J., Owji, A. A., Hay, D. L., Choksi, T. P., Chakravarty, P., Legon, S., & Poyner, D. R. (2002). Adrenomedullin: receptor and signal transduction. Biochemical Society Transactions, 30(4), 432-437. https://doi.org/10.1042/bst0300432