TY - JOUR
T1 - Adult stem cell treatment for central nervous system injury
AU - Mead, Ben
AU - Logan, Ann
AU - Berry, Martin
AU - Leadbeater, Wendy
AU - Scheven, Ben A.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Stem cells possess both self-renewing and multi-lineage differentiation properties and are being explored extensively for use as a cellular therapy for regenerative medicine. Historically, replacement of lost neurons and restoration of neural circuits was primarily considered as the main mechanism by which stem cells restore function in the injured central nervous system (CNS). However, evidence is accumulating that implicates stem cell-derived trophic factors in the neuroprotection of compromised endogenous neurons and regeneration of their axons and dendrites. In this concise review, we summarise the potential of bone marrow-derived stem cells (BMSC), adipose-derived mesenchymal stem cells (AMSC), dental pulp stem cells (DPSC) and neural stem cells (NSC) to repair the injured CNS, with particular reference to spinal cord injury and optic nerve/retinal injury.
AB - Stem cells possess both self-renewing and multi-lineage differentiation properties and are being explored extensively for use as a cellular therapy for regenerative medicine. Historically, replacement of lost neurons and restoration of neural circuits was primarily considered as the main mechanism by which stem cells restore function in the injured central nervous system (CNS). However, evidence is accumulating that implicates stem cell-derived trophic factors in the neuroprotection of compromised endogenous neurons and regeneration of their axons and dendrites. In this concise review, we summarise the potential of bone marrow-derived stem cells (BMSC), adipose-derived mesenchymal stem cells (AMSC), dental pulp stem cells (DPSC) and neural stem cells (NSC) to repair the injured CNS, with particular reference to spinal cord injury and optic nerve/retinal injury.
KW - Cell transplantation
KW - Medicine
KW - Mesenchymal stem cells
KW - Neural stem cells
KW - Regenerative spinal cord injury
KW - Retina
UR - http://www.scopus.com/inward/record.url?scp=85043223220&partnerID=8YFLogxK
UR - http://www.eurekaselect.com/125314
U2 - 10.2174/2211542003666141013223828
DO - 10.2174/2211542003666141013223828
M3 - Article
AN - SCOPUS:85043223220
SN - 2211-5420
VL - 3
SP - 93
EP - 101
JO - Current Tissue Engineering
JF - Current Tissue Engineering
IS - 2
ER -