Adult stem cell treatment for central nervous system injury

Ben Mead*, Ann Logan, Martin Berry, Wendy Leadbeater, Ben A. Scheven

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Stem cells possess both self-renewing and multi-lineage differentiation properties and are being explored extensively for use as a cellular therapy for regenerative medicine. Historically, replacement of lost neurons and restoration of neural circuits was primarily considered as the main mechanism by which stem cells restore function in the injured central nervous system (CNS). However, evidence is accumulating that implicates stem cell-derived trophic factors in the neuroprotection of compromised endogenous neurons and regeneration of their axons and dendrites. In this concise review, we summarise the potential of bone marrow-derived stem cells (BMSC), adipose-derived mesenchymal stem cells (AMSC), dental pulp stem cells (DPSC) and neural stem cells (NSC) to repair the injured CNS, with particular reference to spinal cord injury and optic nerve/retinal injury.

Original languageEnglish
Pages (from-to)93-101
Number of pages9
JournalCurrent Tissue Engineering
Volume3
Issue number2
DOIs
Publication statusPublished - 1 Dec 2014

Fingerprint

Nervous System Trauma
Adult Stem Cells
Stem Cells
Central Nervous System
Optic Nerve Injuries
Neurons
Dental Pulp
Regenerative Medicine
Neural Stem Cells
Dendrites
Mesenchymal Stromal Cells
Spinal Cord Injuries
Axons
Regeneration
Bone Marrow

Keywords

  • Cell transplantation
  • Medicine
  • Mesenchymal stem cells
  • Neural stem cells
  • Regenerative spinal cord injury
  • Retina

Cite this

Mead, B., Logan, A., Berry, M., Leadbeater, W., & Scheven, B. A. (2014). Adult stem cell treatment for central nervous system injury. Current Tissue Engineering, 3(2), 93-101. https://doi.org/10.2174/2211542003666141013223828
Mead, Ben ; Logan, Ann ; Berry, Martin ; Leadbeater, Wendy ; Scheven, Ben A. / Adult stem cell treatment for central nervous system injury. In: Current Tissue Engineering. 2014 ; Vol. 3, No. 2. pp. 93-101.
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Mead, B, Logan, A, Berry, M, Leadbeater, W & Scheven, BA 2014, 'Adult stem cell treatment for central nervous system injury', Current Tissue Engineering, vol. 3, no. 2, pp. 93-101. https://doi.org/10.2174/2211542003666141013223828

Adult stem cell treatment for central nervous system injury. / Mead, Ben; Logan, Ann; Berry, Martin; Leadbeater, Wendy; Scheven, Ben A.

In: Current Tissue Engineering, Vol. 3, No. 2, 01.12.2014, p. 93-101.

Research output: Contribution to journalArticle

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Mead B, Logan A, Berry M, Leadbeater W, Scheven BA. Adult stem cell treatment for central nervous system injury. Current Tissue Engineering. 2014 Dec 1;3(2):93-101. https://doi.org/10.2174/2211542003666141013223828