Adult stem cell treatment for central nervous system injury

Ben Mead; Ann Logan; Martin Berry; Wendy Leadbeater; Ben A. Scheven

doi:10.2174/2211542003666141013223828

Adult stem cell treatment for central nervous system injury

Ben Mead^*, Ann Logan, Martin Berry, Wendy Leadbeater, Ben A. Scheven

^*Corresponding author for this work

Aston Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Stem cells possess both self-renewing and multi-lineage differentiation properties and are being explored extensively for use as a cellular therapy for regenerative medicine. Historically, replacement of lost neurons and restoration of neural circuits was primarily considered as the main mechanism by which stem cells restore function in the injured central nervous system (CNS). However, evidence is accumulating that implicates stem cell-derived trophic factors in the neuroprotection of compromised endogenous neurons and regeneration of their axons and dendrites. In this concise review, we summarise the potential of bone marrow-derived stem cells (BMSC), adipose-derived mesenchymal stem cells (AMSC), dental pulp stem cells (DPSC) and neural stem cells (NSC) to repair the injured CNS, with particular reference to spinal cord injury and optic nerve/retinal injury.

Original language	English
Pages (from-to)	93-101
Number of pages	9
Journal	Current Tissue Engineering
Volume	3
Issue number	2
DOIs	https://doi.org/10.2174/2211542003666141013223828
Publication status	Published - 1 Dec 2014

Keywords

Cell transplantation
Medicine
Mesenchymal stem cells
Neural stem cells
Regenerative spinal cord injury
Retina

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10.2174/2211542003666141013223828

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AU - Mead, Ben

AU - Logan, Ann

AU - Berry, Martin

AU - Leadbeater, Wendy

AU - Scheven, Ben A.

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Adult stem cell treatment for central nervous system injury

Abstract

Keywords

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