Age-related macular degeneration and nutritional supplementation: a review of randomised controlled trials

Hannah E. Bartlett*, Frank Eperjesi

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Age-related macular degeneration (AMD) is the leading cause of severe vision loss in the developed world. The lack of effective treatment modalities, coupled with evidence supporting an oxidative pathogenesis, has increased interest in the potential preventative role of nutritional supplementation. This article reviews seven randomised controlled trials (RCTs) that have investigated the role of nutritional supplementation in AMD. Three of these trials reported a positive effect of nutritional supplementation on AMD; the Age-related eye study (AREDS), the Lutein Antioxidant Supplementation Trial (LAST), and the oral zinc trial by Newsome et al. (1988). However, the oral zinc trial by Newsome et al. (1988) was unlikely to detect any difference between treatments smaller than 72%, and the AREDS results were based on a subgroup of their study population. Lutein was considered for the AREDS formulation, but was not commercially available at that time. The findings of the LAST support a possible therapeutic role of lutein in AMD. © 2004 The College of Optometrists.

Original languageEnglish
Pages (from-to)383-399
Number of pages17
JournalOphthalmic and Physiological Optics
Volume23
Issue number5
DOIs
Publication statusPublished - 2 Sep 2003

Fingerprint

Lutein
Macular Degeneration
Randomized Controlled Trials
Zinc
Antioxidants
Therapeutics
Population

Bibliographical note

© 2003 The College of Optometrists. Published by Wiley-Blackwell.

Keywords

  • age-related macular degeneration
  • antioxidants
  • carotenoids
  • lutein
  • randomised controlled trials

Cite this

@article{1a2dba7560604f49bf4a8b4699ae9776,
title = "Age-related macular degeneration and nutritional supplementation: a review of randomised controlled trials",
abstract = "Age-related macular degeneration (AMD) is the leading cause of severe vision loss in the developed world. The lack of effective treatment modalities, coupled with evidence supporting an oxidative pathogenesis, has increased interest in the potential preventative role of nutritional supplementation. This article reviews seven randomised controlled trials (RCTs) that have investigated the role of nutritional supplementation in AMD. Three of these trials reported a positive effect of nutritional supplementation on AMD; the Age-related eye study (AREDS), the Lutein Antioxidant Supplementation Trial (LAST), and the oral zinc trial by Newsome et al. (1988). However, the oral zinc trial by Newsome et al. (1988) was unlikely to detect any difference between treatments smaller than 72{\%}, and the AREDS results were based on a subgroup of their study population. Lutein was considered for the AREDS formulation, but was not commercially available at that time. The findings of the LAST support a possible therapeutic role of lutein in AMD. {\circledC} 2004 The College of Optometrists.",
keywords = "age-related macular degeneration, antioxidants, carotenoids, lutein, randomised controlled trials",
author = "Bartlett, {Hannah E.} and Frank Eperjesi",
note = "{\circledC} 2003 The College of Optometrists. Published by Wiley-Blackwell.",
year = "2003",
month = "9",
day = "2",
doi = "10.1046/j.1475-1313.2003.00130.x",
language = "English",
volume = "23",
pages = "383--399",
journal = "Ophthalmic and Physiological Optics",
issn = "0275-5408",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Age-related macular degeneration and nutritional supplementation

T2 - a review of randomised controlled trials

AU - Bartlett, Hannah E.

AU - Eperjesi, Frank

N1 - © 2003 The College of Optometrists. Published by Wiley-Blackwell.

PY - 2003/9/2

Y1 - 2003/9/2

N2 - Age-related macular degeneration (AMD) is the leading cause of severe vision loss in the developed world. The lack of effective treatment modalities, coupled with evidence supporting an oxidative pathogenesis, has increased interest in the potential preventative role of nutritional supplementation. This article reviews seven randomised controlled trials (RCTs) that have investigated the role of nutritional supplementation in AMD. Three of these trials reported a positive effect of nutritional supplementation on AMD; the Age-related eye study (AREDS), the Lutein Antioxidant Supplementation Trial (LAST), and the oral zinc trial by Newsome et al. (1988). However, the oral zinc trial by Newsome et al. (1988) was unlikely to detect any difference between treatments smaller than 72%, and the AREDS results were based on a subgroup of their study population. Lutein was considered for the AREDS formulation, but was not commercially available at that time. The findings of the LAST support a possible therapeutic role of lutein in AMD. © 2004 The College of Optometrists.

AB - Age-related macular degeneration (AMD) is the leading cause of severe vision loss in the developed world. The lack of effective treatment modalities, coupled with evidence supporting an oxidative pathogenesis, has increased interest in the potential preventative role of nutritional supplementation. This article reviews seven randomised controlled trials (RCTs) that have investigated the role of nutritional supplementation in AMD. Three of these trials reported a positive effect of nutritional supplementation on AMD; the Age-related eye study (AREDS), the Lutein Antioxidant Supplementation Trial (LAST), and the oral zinc trial by Newsome et al. (1988). However, the oral zinc trial by Newsome et al. (1988) was unlikely to detect any difference between treatments smaller than 72%, and the AREDS results were based on a subgroup of their study population. Lutein was considered for the AREDS formulation, but was not commercially available at that time. The findings of the LAST support a possible therapeutic role of lutein in AMD. © 2004 The College of Optometrists.

KW - age-related macular degeneration

KW - antioxidants

KW - carotenoids

KW - lutein

KW - randomised controlled trials

UR - http://www.scopus.com/inward/record.url?scp=0242273158&partnerID=8YFLogxK

UR - http://onlinelibrary.wiley.com/doi/10.1046/j.1475-1313.2003.00130.x/abstract

U2 - 10.1046/j.1475-1313.2003.00130.x

DO - 10.1046/j.1475-1313.2003.00130.x

M3 - Article

C2 - 12950886

VL - 23

SP - 383

EP - 399

JO - Ophthalmic and Physiological Optics

JF - Ophthalmic and Physiological Optics

SN - 0275-5408

IS - 5

ER -