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Alpha-Lipoic Acid and Its Enantiomers Prevent Methemoglobin Formation and DNA Damage Induced by Dapsone Hydroxylamine: Molecular Mechanism and Antioxidant Action

  • Kaio Murilo Monteiro Espíndola
  • , Everton Luiz Pompeu Varela
  • , Rosyana de Fátima Vieira de Albuquerque
  • , Rosiane Araújo Figueiredo
  • , Sávio Monteiro Dos Santos
  • , Nívea Silva Malcher
  • , Pamela Suelen da S Seabra
  • , Andréia do Nascimento Fonseca
  • , Karla Marcely de Azevedo Sousa
  • , Susan Beatriz Batista de Oliveira
  • , Agnaldo da Silva Carneiro
  • , Michael D Coleman
  • , Marta Chagas Monteiro
  • Postgraduate Program in Pharmacology and Biochemistry, Faculty of Pharmacy, Federal University of Pará/UFPA, Belém 66075-110, PA, Brazil.
  • Postgraduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Pará/UFPA, Belém 66075-110, PA, Brazil.
  • Laboratory Immunology, Microbiology and In Vitro Assays (LABEIM), Faculty of Pharmacy, Federal University of Pará/UFPA, Belém 66075-110, PA, Brazil.
  • Postgraduate Program in Neuroscience and Cell Biology, Faculty of Pharmacy, Federal University of Pará/UFPA, Belém 66075-110, PA, Brazil.
  • Postgraduate Program in Medicinal Chemistry and Molecular Modeling, Faculty of Pharmacy, Federal University of Pará/UFPA, Belém 66075-110, PA, Brazil.

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Pharmacology, Toxicology and Pharmaceutical Science