Alzheimer’s disease and the eye

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

Dementia, including Alzheimer’s disease (AD), is a major disorder causing visual problems in the elderly population. The pathology of AD includes the deposition in the brain of abnormal aggregates of ß-amyloid (Aß) in the form of senile plaques (SP) and abnormally phosphorylated tau in the form of neurofibrillary tangles (NFT). A variety of visual problems have been reported in patients with AD including loss of visual acuity (VA), colour vision and visual fields; changes in pupillary response to mydriatics, defects in fixation and in smooth and saccadic eye movements; changes in contrast sensitivity and in visual evoked potentials (VEP); and disturbances of complex visual functions such as reading, visuospatial function, and in the naming and identification of objects. Many of these changes are controversial with conflicting data in the literature and no ocular or visual feature can be regarded as particularly diagnostic of AD. In addition, some pathological changes have been observed to affect the eye, visual pathway, and visual cortex in AD. The optometrist has a role in helping a patient with AD, if it is believed that signs and symptoms of the disease are present, so as to optimize visual function and improve the quality of life. (J Optom 2009;2:103-111 ©2009 Spanish Council of Optometry)
LanguageEnglish
Pages102-111
Number of pages10
JournalJournal of Optometry
Volume2
Issue number3
DOIs
Publication statusPublished - 2009

Fingerprint

Alzheimer Disease
Optometry
Mydriatics
Color Vision
Neurofibrillary Tangles
Contrast Sensitivity
Visual Pathways
Visual Evoked Potentials
Saccades
Vision Disorders
Amyloid Plaques
Visual Cortex
Visual Fields
Amyloid
Visual Acuity
Signs and Symptoms
Dementia
Reading
Quality of Life
Pathology

Keywords

  • Alzheimer’s disease
  • dementia
  • ocular features
  • visual features
  • pathology
  • eye
  • visual cortex

Cite this

Armstrong, Richard A. / Alzheimer’s disease and the eye. In: Journal of Optometry. 2009 ; Vol. 2, No. 3. pp. 102-111.
@article{e17ad2be1100458f80658f5b18eb76e0,
title = "Alzheimer’s disease and the eye",
abstract = "Dementia, including Alzheimer’s disease (AD), is a major disorder causing visual problems in the elderly population. The pathology of AD includes the deposition in the brain of abnormal aggregates of {\ss}-amyloid (A{\ss}) in the form of senile plaques (SP) and abnormally phosphorylated tau in the form of neurofibrillary tangles (NFT). A variety of visual problems have been reported in patients with AD including loss of visual acuity (VA), colour vision and visual fields; changes in pupillary response to mydriatics, defects in fixation and in smooth and saccadic eye movements; changes in contrast sensitivity and in visual evoked potentials (VEP); and disturbances of complex visual functions such as reading, visuospatial function, and in the naming and identification of objects. Many of these changes are controversial with conflicting data in the literature and no ocular or visual feature can be regarded as particularly diagnostic of AD. In addition, some pathological changes have been observed to affect the eye, visual pathway, and visual cortex in AD. The optometrist has a role in helping a patient with AD, if it is believed that signs and symptoms of the disease are present, so as to optimize visual function and improve the quality of life. (J Optom 2009;2:103-111 {\circledC}2009 Spanish Council of Optometry)",
keywords = "Alzheimer’s disease, dementia, ocular features, visual features, pathology, eye, visual cortex",
author = "Armstrong, {Richard A.}",
year = "2009",
doi = "10.3921/joptom.2009.103",
language = "English",
volume = "2",
pages = "102--111",
journal = "Journal of Optometry",
issn = "1888-4296",
publisher = "Spanish Council of Optometry",
number = "3",

}

Alzheimer’s disease and the eye. / Armstrong, Richard A.

In: Journal of Optometry, Vol. 2, No. 3, 2009, p. 102-111.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alzheimer’s disease and the eye

AU - Armstrong, Richard A.

PY - 2009

Y1 - 2009

N2 - Dementia, including Alzheimer’s disease (AD), is a major disorder causing visual problems in the elderly population. The pathology of AD includes the deposition in the brain of abnormal aggregates of ß-amyloid (Aß) in the form of senile plaques (SP) and abnormally phosphorylated tau in the form of neurofibrillary tangles (NFT). A variety of visual problems have been reported in patients with AD including loss of visual acuity (VA), colour vision and visual fields; changes in pupillary response to mydriatics, defects in fixation and in smooth and saccadic eye movements; changes in contrast sensitivity and in visual evoked potentials (VEP); and disturbances of complex visual functions such as reading, visuospatial function, and in the naming and identification of objects. Many of these changes are controversial with conflicting data in the literature and no ocular or visual feature can be regarded as particularly diagnostic of AD. In addition, some pathological changes have been observed to affect the eye, visual pathway, and visual cortex in AD. The optometrist has a role in helping a patient with AD, if it is believed that signs and symptoms of the disease are present, so as to optimize visual function and improve the quality of life. (J Optom 2009;2:103-111 ©2009 Spanish Council of Optometry)

AB - Dementia, including Alzheimer’s disease (AD), is a major disorder causing visual problems in the elderly population. The pathology of AD includes the deposition in the brain of abnormal aggregates of ß-amyloid (Aß) in the form of senile plaques (SP) and abnormally phosphorylated tau in the form of neurofibrillary tangles (NFT). A variety of visual problems have been reported in patients with AD including loss of visual acuity (VA), colour vision and visual fields; changes in pupillary response to mydriatics, defects in fixation and in smooth and saccadic eye movements; changes in contrast sensitivity and in visual evoked potentials (VEP); and disturbances of complex visual functions such as reading, visuospatial function, and in the naming and identification of objects. Many of these changes are controversial with conflicting data in the literature and no ocular or visual feature can be regarded as particularly diagnostic of AD. In addition, some pathological changes have been observed to affect the eye, visual pathway, and visual cortex in AD. The optometrist has a role in helping a patient with AD, if it is believed that signs and symptoms of the disease are present, so as to optimize visual function and improve the quality of life. (J Optom 2009;2:103-111 ©2009 Spanish Council of Optometry)

KW - Alzheimer’s disease

KW - dementia

KW - ocular features

KW - visual features

KW - pathology

KW - eye

KW - visual cortex

UR - http://www.scopus.com/inward/record.url?scp=70349980024&partnerID=8YFLogxK

U2 - 10.3921/joptom.2009.103

DO - 10.3921/joptom.2009.103

M3 - Article

VL - 2

SP - 102

EP - 111

JO - Journal of Optometry

T2 - Journal of Optometry

JF - Journal of Optometry

SN - 1888-4296

IS - 3

ER -