Alzheimer's disease: the relationship between the density of senile plaques, neurofibrillary tangles and A4 protein in human patients

Richard A. Armstrong, D. Myers, C.U.M. Smith, Nigel J. Cairns, P.J. Luthert

Research output: Contribution to journalArticle

Abstract

The numerical density of senile plaques (SP) and neurofibrillary tangles (NFT) as revealed by the Glees silver method was compared with SP and NFT revealed by the Gallyas method and with amyloid (A4) deposits in immunostained sections in 6 elderly cases of Alzheimer's disease. The density of NFT was generally greater and A4 lower in tissue from hippocampus compared with the neocortex suggesting that A4 deposition was less important than the degree of paired helical filament (PHF) related damage in the hippocampus. The density of Glees SP was positively correlated Gallyas SP weakly correlated with A4 deposit number. A stepwise multiple regression analysis which included A4 deposit and Gallyas SP density and accounted for 54% of the variation in Glees SP density. Hence, different populations of SP were revealed by the different staining methods. The results suggested that the Glees method may stain a population of SP in a region of cortex where both amyloid deposition and neurofibrillary changes have occurred.
Original languageEnglish
Pages (from-to)141-3
Number of pages3
JournalNeuroscience Letters
Volume123
Issue number2
DOIs
Publication statusPublished - 25 Feb 1991

Keywords

  • Alzheimer's disease
  • senile plaque
  • neurofibrillary tangle
  • A4 deposit

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