Abstract
This paper describes the design, development and succesful use of an on-chip goniometer for room-temperature macromolecular crystallography via acoustically induced rotations. We present for the first time a low cost, rate-tunable, acoustic actuator for randomised in-fluid sample orientation and its utilisation for protein structure determination on a synchrotron beamline. The device enables the efficient collection of diffraction data via a rotation method from a sample within a surface confined droplet. This method facillitates efficient macromolecular structural data acquisition in fluid environments for dynamical studies.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Lab on a Chip |
| DOIs | |
| Publication status | Published - 1 Nov 2017 |
Bibliographical note
© Royal Society of Chemistry 2017Funding: Strategic Award from the Wellcome Trust and the
Biotechnology and Biological Sciences Research Council
(grant 102593).
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Profiles
Mark Prince
- Engineering & Applied Science
- Mechanical Engineering & Design - Senior Lecturer
- Aston Institute of Materials Research (AIMR)
Person: Academic
Cite this
Burton, C. G. G., Axford, D., Edwards, A. M. J., Gildea, R. J., Morris, R. H., Newton, M. I., Orville, A. M., Prince, M., Topham, P., & Docker, P. (2017). An Acoustic On-Chip Goniometer for Room Temperature Macromolecular Crystallography. Lab on a Chip, 1-7. https://doi.org/10.1039/C7LC00812K