An Acoustic On-Chip Goniometer for Room Temperature Macromolecular Crystallography

Christian George George Burton, Danny Axford, Andrew Michael John Edwards, Richard J Gildea, Robert H Morris, Michael I Newton, Allen M Orville, Mark Prince, Paul Topham, Peter Docker

Research output: Contribution to journalArticlepeer-review


This paper describes the design, development and succesful use of an on-chip goniometer for room-temperature macromolecular crystallography via acoustically induced rotations. We present for the first time a low cost, rate-tunable, acoustic actuator for randomised in-fluid sample orientation and its utilisation for protein structure determination on a synchrotron beamline. The device enables the efficient collection of diffraction data via a rotation method from a sample within a surface confined droplet. This method facillitates efficient macromolecular structural data acquisition in fluid environments for dynamical studies.
Original languageEnglish
Pages (from-to)4225-4230
Number of pages7
JournalLab on a Chip
Issue number24
Early online date1 Nov 2017
Publication statusPublished - 21 Dec 2017

Bibliographical note

© Royal Society of Chemistry 2017

Funding: Strategic Award from the Wellcome Trust and the
Biotechnology and Biological Sciences Research Council
(grant 102593).


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