An evaluation of kurtosis beamforming in magnetoencephalography to localize the epileptogenic zone in drug resistant epilepsy patients

Michael B H Hall, Ida A Nissen, Elisabeth C W van Straaten, Paul L Furlong, Caroline Witton, Elaine Foley, Stefano Seri, Arjan Hillebrand

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Kurtosis beamforming is a useful technique for analysing magnetoencephalograpy (MEG) data containing epileptic spikes. However, the implementation varies and few studies measure concordance with subsequently resected areas. We evaluated kurtosis beamforming as a means of localizing spikes in drug-resistant epilepsy patients.

METHODS: We retrospectively applied kurtosis beamforming to MEG recordings of 22 epilepsy patients that had previously been analysed using equivalent current dipole (ECD) fitting. Virtual electrodes were placed in the kurtosis volumetric peaks and visually inspected to select a candidate source. The candidate sources were compared to the ECD localizations and resection areas.

RESULTS: The kurtosis beamformer produced interpretable localizations in 18/22 patients, of which the candidate source coincided with the resection lobe in 9/13 seizure-free patients and in 3/5 patients with persistent seizures. The sublobar accuracy of the kurtosis beamformer with respect to the resection zone was higher than ECD (56% and 50%, respectively), however, ECD resulted in a higher lobar accuracy (75%, 67%).

CONCLUSIONS: Kurtosis beamforming may provide additional value when spikes are not clearly discernible on the sensors and support ECD localizations when dipoles are scattered.

SIGNIFICANCE: Kurtosis beamforming should be integrated with existing clinical protocols to assist in localizing the epileptogenic zone.

LanguageEnglish
Pages1221-1229
Number of pages9
JournalClinical Neurophysiology
Volume129
Issue number6
Early online date9 Mar 2018
DOIs
Publication statusPublished - 1 Jun 2018

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Magnetoencephalography
Seizures
Clinical Protocols
Epilepsy
Electrodes
Drug Resistant Epilepsy

Bibliographical note

© 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Funding: Funding: Dutch Epilepsy Foundation (project 14-16) and an MRC UK MEG Partnership Grant, MR/K005464/1 and an MRC Doctoral Training Grant, MR/K501086/1.

Keywords

  • Adult
  • Brain/diagnostic imaging
  • Brain Mapping
  • Drug Resistant Epilepsy/diagnostic imaging
  • Humans
  • Magnetoencephalography
  • Male
  • Middle Aged
  • Neuroimaging/methods
  • Retrospective Studies
  • Seizures/diagnostic imaging
  • Young Adult

Cite this

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abstract = "OBJECTIVE: Kurtosis beamforming is a useful technique for analysing magnetoencephalograpy (MEG) data containing epileptic spikes. However, the implementation varies and few studies measure concordance with subsequently resected areas. We evaluated kurtosis beamforming as a means of localizing spikes in drug-resistant epilepsy patients.METHODS: We retrospectively applied kurtosis beamforming to MEG recordings of 22 epilepsy patients that had previously been analysed using equivalent current dipole (ECD) fitting. Virtual electrodes were placed in the kurtosis volumetric peaks and visually inspected to select a candidate source. The candidate sources were compared to the ECD localizations and resection areas.RESULTS: The kurtosis beamformer produced interpretable localizations in 18/22 patients, of which the candidate source coincided with the resection lobe in 9/13 seizure-free patients and in 3/5 patients with persistent seizures. The sublobar accuracy of the kurtosis beamformer with respect to the resection zone was higher than ECD (56{\%} and 50{\%}, respectively), however, ECD resulted in a higher lobar accuracy (75{\%}, 67{\%}).CONCLUSIONS: Kurtosis beamforming may provide additional value when spikes are not clearly discernible on the sensors and support ECD localizations when dipoles are scattered.SIGNIFICANCE: Kurtosis beamforming should be integrated with existing clinical protocols to assist in localizing the epileptogenic zone.",
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An evaluation of kurtosis beamforming in magnetoencephalography to localize the epileptogenic zone in drug resistant epilepsy patients. / Hall, Michael B H; Nissen, Ida A; van Straaten, Elisabeth C W; Furlong, Paul L; Witton, Caroline; Foley, Elaine; Seri, Stefano; Hillebrand, Arjan.

In: Clinical Neurophysiology , Vol. 129, No. 6, 01.06.2018, p. 1221-1229.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An evaluation of kurtosis beamforming in magnetoencephalography to localize the epileptogenic zone in drug resistant epilepsy patients

AU - Hall, Michael B H

AU - Nissen, Ida A

AU - van Straaten, Elisabeth C W

AU - Furlong, Paul L

AU - Witton, Caroline

AU - Foley, Elaine

AU - Seri, Stefano

AU - Hillebrand, Arjan

N1 - © 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Funding: Funding: Dutch Epilepsy Foundation (project 14-16) and an MRC UK MEG Partnership Grant, MR/K005464/1 and an MRC Doctoral Training Grant, MR/K501086/1.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - OBJECTIVE: Kurtosis beamforming is a useful technique for analysing magnetoencephalograpy (MEG) data containing epileptic spikes. However, the implementation varies and few studies measure concordance with subsequently resected areas. We evaluated kurtosis beamforming as a means of localizing spikes in drug-resistant epilepsy patients.METHODS: We retrospectively applied kurtosis beamforming to MEG recordings of 22 epilepsy patients that had previously been analysed using equivalent current dipole (ECD) fitting. Virtual electrodes were placed in the kurtosis volumetric peaks and visually inspected to select a candidate source. The candidate sources were compared to the ECD localizations and resection areas.RESULTS: The kurtosis beamformer produced interpretable localizations in 18/22 patients, of which the candidate source coincided with the resection lobe in 9/13 seizure-free patients and in 3/5 patients with persistent seizures. The sublobar accuracy of the kurtosis beamformer with respect to the resection zone was higher than ECD (56% and 50%, respectively), however, ECD resulted in a higher lobar accuracy (75%, 67%).CONCLUSIONS: Kurtosis beamforming may provide additional value when spikes are not clearly discernible on the sensors and support ECD localizations when dipoles are scattered.SIGNIFICANCE: Kurtosis beamforming should be integrated with existing clinical protocols to assist in localizing the epileptogenic zone.

AB - OBJECTIVE: Kurtosis beamforming is a useful technique for analysing magnetoencephalograpy (MEG) data containing epileptic spikes. However, the implementation varies and few studies measure concordance with subsequently resected areas. We evaluated kurtosis beamforming as a means of localizing spikes in drug-resistant epilepsy patients.METHODS: We retrospectively applied kurtosis beamforming to MEG recordings of 22 epilepsy patients that had previously been analysed using equivalent current dipole (ECD) fitting. Virtual electrodes were placed in the kurtosis volumetric peaks and visually inspected to select a candidate source. The candidate sources were compared to the ECD localizations and resection areas.RESULTS: The kurtosis beamformer produced interpretable localizations in 18/22 patients, of which the candidate source coincided with the resection lobe in 9/13 seizure-free patients and in 3/5 patients with persistent seizures. The sublobar accuracy of the kurtosis beamformer with respect to the resection zone was higher than ECD (56% and 50%, respectively), however, ECD resulted in a higher lobar accuracy (75%, 67%).CONCLUSIONS: Kurtosis beamforming may provide additional value when spikes are not clearly discernible on the sensors and support ECD localizations when dipoles are scattered.SIGNIFICANCE: Kurtosis beamforming should be integrated with existing clinical protocols to assist in localizing the epileptogenic zone.

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KW - Brain/diagnostic imaging

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KW - Magnetoencephalography

KW - Male

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KW - Neuroimaging/methods

KW - Retrospective Studies

KW - Seizures/diagnostic imaging

KW - Young Adult

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