An fMRI investigation into the effect of preceding stimuli during visual oddball tasks

Jiří Fajkus, Michal Mikl, Daniel Joel Shaw, Milan Brázdil

Research output: Contribution to journalArticle

Abstract

Background: This study investigates the modulatory effect of stimulus sequence on neural responses to novel stimuli. A group of 34 healthy volunteers underwent event-related functional magnetic resonance imaging while performing a three-stimulus visual oddball task, involving randomly presented frequent stimuli and two types of infrequent stimuli - targets and distractors. New method: We developed a modified categorization of rare stimuli that incorporated the type of preceding rare stimulus, and analyzed the event-related functional data according to this sequence categorization; specifically, we explored hemodynamic response modulation associated with increasing rare-to-rare stimulus interval. Results: For two consecutive targets, a modulation of brain function was evident throughout posterior midline and lateral temporal cortex, while responses to targets preceded by distractors were modulated in a widely distributed fronto-parietal system. As for distractors that follow targets, brain function was modulated throughout a set of posterior brain structures. For two successive distractors, however, no significant modulation was observed, which is consistent with previous studies and our primary hypothesis. Comparison with existing methods: The addition of the aforementioned technique extends the possibilities of conventional oddball task analysis, enabling researchers to explore the effects of the whole range of rare stimuli intervals. Conclusion: This methodology can be applied to study a wide range of associated cognitive mechanisms, such as decision making, expectancy and attention.

LanguageEnglish
Pages56-61
Number of pages6
JournalJournal of Neuroscience Methods
Volume251
DOIs
Publication statusPublished - 5 Aug 2015

Fingerprint

Magnetic Resonance Imaging
Brain
Temporal Lobe
Decision Making
Healthy Volunteers
Hemodynamics
Research Personnel

Keywords

  • Attention
  • FMRI
  • Oddball
  • Parametric modulation
  • Stimulus sequence
  • Target

Cite this

@article{efc98f96d6d1438d9f1061511e2850c8,
title = "An fMRI investigation into the effect of preceding stimuli during visual oddball tasks",
abstract = "Background: This study investigates the modulatory effect of stimulus sequence on neural responses to novel stimuli. A group of 34 healthy volunteers underwent event-related functional magnetic resonance imaging while performing a three-stimulus visual oddball task, involving randomly presented frequent stimuli and two types of infrequent stimuli - targets and distractors. New method: We developed a modified categorization of rare stimuli that incorporated the type of preceding rare stimulus, and analyzed the event-related functional data according to this sequence categorization; specifically, we explored hemodynamic response modulation associated with increasing rare-to-rare stimulus interval. Results: For two consecutive targets, a modulation of brain function was evident throughout posterior midline and lateral temporal cortex, while responses to targets preceded by distractors were modulated in a widely distributed fronto-parietal system. As for distractors that follow targets, brain function was modulated throughout a set of posterior brain structures. For two successive distractors, however, no significant modulation was observed, which is consistent with previous studies and our primary hypothesis. Comparison with existing methods: The addition of the aforementioned technique extends the possibilities of conventional oddball task analysis, enabling researchers to explore the effects of the whole range of rare stimuli intervals. Conclusion: This methodology can be applied to study a wide range of associated cognitive mechanisms, such as decision making, expectancy and attention.",
keywords = "Attention, FMRI, Oddball, Parametric modulation, Stimulus sequence, Target",
author = "Jiř{\'i} Fajkus and Michal Mikl and Shaw, {Daniel Joel} and Milan Br{\'a}zdil",
year = "2015",
month = "8",
day = "5",
doi = "10.1016/j.jneumeth.2015.05.005",
language = "English",
volume = "251",
pages = "56--61",
journal = "Journal of Neuroscience Methods",
issn = "0165-0270",
publisher = "Elsevier",

}

An fMRI investigation into the effect of preceding stimuli during visual oddball tasks. / Fajkus, Jiří; Mikl, Michal; Shaw, Daniel Joel; Brázdil, Milan.

In: Journal of Neuroscience Methods, Vol. 251, 05.08.2015, p. 56-61.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An fMRI investigation into the effect of preceding stimuli during visual oddball tasks

AU - Fajkus, Jiří

AU - Mikl, Michal

AU - Shaw, Daniel Joel

AU - Brázdil, Milan

PY - 2015/8/5

Y1 - 2015/8/5

N2 - Background: This study investigates the modulatory effect of stimulus sequence on neural responses to novel stimuli. A group of 34 healthy volunteers underwent event-related functional magnetic resonance imaging while performing a three-stimulus visual oddball task, involving randomly presented frequent stimuli and two types of infrequent stimuli - targets and distractors. New method: We developed a modified categorization of rare stimuli that incorporated the type of preceding rare stimulus, and analyzed the event-related functional data according to this sequence categorization; specifically, we explored hemodynamic response modulation associated with increasing rare-to-rare stimulus interval. Results: For two consecutive targets, a modulation of brain function was evident throughout posterior midline and lateral temporal cortex, while responses to targets preceded by distractors were modulated in a widely distributed fronto-parietal system. As for distractors that follow targets, brain function was modulated throughout a set of posterior brain structures. For two successive distractors, however, no significant modulation was observed, which is consistent with previous studies and our primary hypothesis. Comparison with existing methods: The addition of the aforementioned technique extends the possibilities of conventional oddball task analysis, enabling researchers to explore the effects of the whole range of rare stimuli intervals. Conclusion: This methodology can be applied to study a wide range of associated cognitive mechanisms, such as decision making, expectancy and attention.

AB - Background: This study investigates the modulatory effect of stimulus sequence on neural responses to novel stimuli. A group of 34 healthy volunteers underwent event-related functional magnetic resonance imaging while performing a three-stimulus visual oddball task, involving randomly presented frequent stimuli and two types of infrequent stimuli - targets and distractors. New method: We developed a modified categorization of rare stimuli that incorporated the type of preceding rare stimulus, and analyzed the event-related functional data according to this sequence categorization; specifically, we explored hemodynamic response modulation associated with increasing rare-to-rare stimulus interval. Results: For two consecutive targets, a modulation of brain function was evident throughout posterior midline and lateral temporal cortex, while responses to targets preceded by distractors were modulated in a widely distributed fronto-parietal system. As for distractors that follow targets, brain function was modulated throughout a set of posterior brain structures. For two successive distractors, however, no significant modulation was observed, which is consistent with previous studies and our primary hypothesis. Comparison with existing methods: The addition of the aforementioned technique extends the possibilities of conventional oddball task analysis, enabling researchers to explore the effects of the whole range of rare stimuli intervals. Conclusion: This methodology can be applied to study a wide range of associated cognitive mechanisms, such as decision making, expectancy and attention.

KW - Attention

KW - FMRI

KW - Oddball

KW - Parametric modulation

KW - Stimulus sequence

KW - Target

UR - http://www.scopus.com/inward/record.url?scp=84930666225&partnerID=8YFLogxK

UR - https://www.sciencedirect.com/science/article/pii/S0165027015001788?via%3Dihub

U2 - 10.1016/j.jneumeth.2015.05.005

DO - 10.1016/j.jneumeth.2015.05.005

M3 - Article

VL - 251

SP - 56

EP - 61

JO - Journal of Neuroscience Methods

T2 - Journal of Neuroscience Methods

JF - Journal of Neuroscience Methods

SN - 0165-0270

ER -