Serratia spp. are an important cause of hospital-acquired infections and outbreaks in high-risk settings. Twenty-one patients were infected or colonized over a nine-month period during 2001-2002 on a neonatal unit. Twenty-two isolates collected were examined for antibiotic susceptibility, β-lactamase production and genotype. Random-amplified polymorphic DNA polymerase chain reaction and pulsed-field gel electrophoresis revealed that two clones were present. The first clone caused invasive clinical infection in four babies, and was subsequently replaced by a non-invasive clone that affected 14 babies. Phenotypically, the two strains also differed in their prodigiosin production; the first strain was non-pigmented whereas the second strain displayed pink-red pigmentation. Clinical features suggested a difference in their pathogenicity. No environmental source was found. The outbreak terminated following enhanced compliance with infection control measures and a change of antibiotic policy. Although S. marcescens continued to be isolated occasionally for another five months of follow-up, these were sporadic isolates with distinct molecular typing patterns. © 2005 The Hospital Infection Society.
|Number of pages||7|
|Journal||Journal of Hospital Infection|
|Publication status||Published - May 2006|
|Event||11th Annual Conference of the Federation of Infection Societies - Cardiff, United Kingdom|
Duration: 23 Nov 2004 → 25 Nov 2004
Bibliographical noteThis work was presented, in part, in poster format at the 11th Annual Conference of the Federation of Infection Societies, Cardiff, 23-25 November 2004.
- infection control
- serratia marcescens