Analysis of skin blood microflow oscillations in patients with rheumatic diseases

Irina Mizeva*, Irina Makovik, Andrey Dunaev, Alexander Krupatkin, Igor Meglinski

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Laser Doppler flowmetry (LDF) has been applied for the assessment of variation in blood microflows in patients with rheumatic diseases and healthy volunteers. Oscillations of peripheral blood microcirculation observed by LDF have been analyzed utilizing a wavelet transform. A higher amplitude of blood microflow oscillations has been observed in a high frequency band (over 0.1 Hz) in patients with rheumatic diseases. Oscillations in the high frequency band decreased in healthy volunteers in response to the cold pressor test, whereas lower frequency pulsations prevailed in patients with rheumatic diseases. A higher perfusion rate at normal conditions was observed in patients, and a weaker response to cold stimulation was observed in healthy volunteers. Analysis of blood microflow oscillations has a high potential for evaluation of mechanisms of blood flow regulation and diagnosis of vascular abnormalities associated with rheumatic diseases.

Original languageEnglish
Article number070501
JournalJournal of Biomedical Optics
Volume22
Issue number7
DOIs
Publication statusPublished - 13 Jul 2017

Bibliographical note

© 2017 Society of Photo-Optical Instrumentation
Engineers (SPIE)

Keywords

  • blood microflows
  • laser Doppler flowmetry
  • oscillations
  • peripheral blood circulation
  • rheumatic
  • wavelet transfer

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