Angiogenic properties of placenta-derived extracellular vesicles in normal pregnancy and in preeclampsia

Natalia Gebara, Yolanda Correia, Keqing Wang, Benedetta Bussolati*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Angiogenesis is one of the main processes that coordinate the biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute to pregnancy’s physiology and pathophysiology, and to the fetal–maternal interaction. The present review outlines the implications of EV-mediated crosstalk in the angiogenic process in healthy pregnancy and its dysregulation in preeclampsia. In particular, the effect of EVs derived from gestational tissues in pro and anti-angiogenic processes in the physiological and pathological setting is described. Moreover, the application of EVs from placental stem cells in the clinical setting is reported.
Original languageEnglish
Article number5402
JournalInternational Journal of Molecular Sciences
Issue number10
Publication statusPublished - 20 May 2021

Bibliographical note

Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (

Funding: European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement number 765274.


  • Angiogenesis
  • Extracellular vesicles
  • Preeclampsia


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