Angiogenic properties of placenta-derived extracellular vesicles in normal pregnancy and in preeclampsia

Natalia Gebara; Yolanda Correia; Keqing Wang; Benedetta Bussolati

doi:10.3390/ijms22105402

Angiogenic properties of placenta-derived extracellular vesicles in normal pregnancy and in preeclampsia

Natalia Gebara
, Yolanda Correia
, Keqing Wang
, Benedetta Bussolati^*

^*Corresponding author for this work

Department of Molecular Biotechnology and Health Sciences, University of Torino, 10124 Torino, Italy

Research output: Contribution to journal › Review article › peer-review

37 Citations (Scopus)

17 Downloads (Pure)

Abstract

Angiogenesis is one of the main processes that coordinate the biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute to pregnancy’s physiology and pathophysiology, and to the fetal–maternal interaction. The present review outlines the implications of EV-mediated crosstalk in the angiogenic process in healthy pregnancy and its dysregulation in preeclampsia. In particular, the effect of EVs derived from gestational tissues in pro and anti-angiogenic processes in the physiological and pathological setting is described. Moreover, the application of EVs from placental stem cells in the clinical setting is reported.

Original language	English
Article number	5402
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	10
DOIs	https://doi.org/10.3390/ijms22105402
Publication status	Published - 20 May 2021

Bibliographical note

Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

Funding: European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement number 765274.

Keywords

Angiogenesis
Extracellular vesicles
Preeclampsia

Access to Document

10.3390/ijms22105402Licence: CC BY 3.0

ijms-22-05402-v2.pdf
Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Final published version, 654 KBLicence: CC BY 3.0

Cite this

@article{4af33bbaadd14a878359291f504d827b,

title = "Angiogenic properties of placenta-derived extracellular vesicles in normal pregnancy and in preeclampsia",

abstract = "Angiogenesis is one of the main processes that coordinate the biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute to pregnancy{\textquoteright}s physiology and pathophysiology, and to the fetal–maternal interaction. The present review outlines the implications of EV-mediated crosstalk in the angiogenic process in healthy pregnancy and its dysregulation in preeclampsia. In particular, the effect of EVs derived from gestational tissues in pro and anti-angiogenic processes in the physiological and pathological setting is described. Moreover, the application of EVs from placental stem cells in the clinical setting is reported.",

keywords = "Angiogenesis, Extracellular vesicles, Preeclampsia",

author = "Natalia Gebara and Yolanda Correia and Keqing Wang and Benedetta Bussolati",

note = "Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Funding: European Union{\textquoteright}s Horizon 2020 research and innovation program under the Marie Sk{\l}odowska-Curie grant agreement number 765274. ",

year = "2021",

month = may,

day = "20",

doi = "10.3390/ijms22105402",

language = "English",

volume = "22",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute",

number = "10",

}

TY - JOUR

T1 - Angiogenic properties of placenta-derived extracellular vesicles in normal pregnancy and in preeclampsia

AU - Gebara, Natalia

AU - Correia, Yolanda

AU - Wang, Keqing

AU - Bussolati, Benedetta

N1 - Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Funding: European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement number 765274.

PY - 2021/5/20

Y1 - 2021/5/20

N2 - Angiogenesis is one of the main processes that coordinate the biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute to pregnancy’s physiology and pathophysiology, and to the fetal–maternal interaction. The present review outlines the implications of EV-mediated crosstalk in the angiogenic process in healthy pregnancy and its dysregulation in preeclampsia. In particular, the effect of EVs derived from gestational tissues in pro and anti-angiogenic processes in the physiological and pathological setting is described. Moreover, the application of EVs from placental stem cells in the clinical setting is reported.

AB - Angiogenesis is one of the main processes that coordinate the biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute to pregnancy’s physiology and pathophysiology, and to the fetal–maternal interaction. The present review outlines the implications of EV-mediated crosstalk in the angiogenic process in healthy pregnancy and its dysregulation in preeclampsia. In particular, the effect of EVs derived from gestational tissues in pro and anti-angiogenic processes in the physiological and pathological setting is described. Moreover, the application of EVs from placental stem cells in the clinical setting is reported.

KW - Angiogenesis

KW - Extracellular vesicles

KW - Preeclampsia

UR - https://www.mdpi.com/1422-0067/22/10/5402

UR - https://www.scopus.com/pages/publications/85106156662

U2 - 10.3390/ijms22105402

DO - 10.3390/ijms22105402

M3 - Review article

SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 10

M1 - 5402

ER -

Angiogenic properties of placenta-derived extracellular vesicles in normal pregnancy and in preeclampsia

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Long-term impacts of preeclampsia on the cardiovascular system using murine models

Cite this

Angiogenic properties of placenta-derived extracellular vesicles in normal pregnancy and in preeclampsia

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Student theses

Long-term impacts of preeclampsia on the cardiovascular system using murine models

Cite this