Angioplasty improves mortality in the managment of acute coronary syndrome in patients with chronic anaemia

Mahvash Zaman, Ramakrishna S. Gorantla, Hardeep Uppal, N. Lavu, Rahul Potluri

    Research output: Contribution to journalArticle

    Abstract

    Aims: Angioplasty has changed the management of acute coronary syndromes (ACS). However,
    in patients with chronic anaemia the evidence for angioplasty in ACS is less well known. We
    sought to investigate the role of angioplasty in patients with anaemia presenting with ACS, and
    how it affected mortality.
    Method: Anonymous information on patients with ACS, attending a large multi-ethnic general
    hospital in Manchester, United Kingdom in the period 2000-2013 was obtained from the local
    health authority computerised hospital activity analysis register using ICD-10 and OPCS coding
    systems according to the ACALM protocol.
    Results: Out of 25294 patients, 1551(6.1%) patients had Anaemia as defined by national
    standards. Of these, 89(5.7%) patients underwent angioplasty with mean age 65.0 years and
    were significantly younger than patients who did not undergo angioplasty. Patients who did not
    undergo angioplasty had higher prevalence of Ischaemic Stroke(6.2% vs 1.1%), Heart
    Failure(36.7% vs 11.2%) and Chronic Kidney Disease(18.7% vs 4.5%), whilst angioplasty
    patients had higher prevalence of previous ACS (27.2% vs 36.0%) and peripheral vascular
    disease(6.8% vs 7.9%). Multi-nominal logistic regression analysis revealed Heart
    Failure(RR2.16), Ischaemic Stroke(RR3.67) and Chronic Kidney Disease(RR1.39) as significant
    predictors of mortality in this patient group. Angioplasty(RR7.81) and previous ACS(RR1.88)
    conferred mortality improvement in this patient group.
    Original languageEnglish
    Article number358
    Pages (from-to)278
    Number of pages1
    JournalCardiology
    Volume132
    Issue numbersupp 1
    DOIs
    Publication statusPublished - 29 Nov 2015

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    Acute Coronary Syndrome
    Angioplasty
    Anemia
    Mortality
    Chronic Renal Insufficiency
    Stroke
    International Classification of Diseases
    Logistic Models
    Regression Analysis

    Bibliographical note

    11th International Congress on Coronary Artery Disease (ICCAD), Florence, Italy November 29 - December 2, 2015: Abstracts

    Cite this

    Zaman, M., Gorantla, R. S., Uppal, H., Lavu, N., & Potluri, R. (2015). Angioplasty improves mortality in the managment of acute coronary syndrome in patients with chronic anaemia. Cardiology, 132(supp 1), 278. [358]. https://doi.org/10.1159/000442375
    Zaman, Mahvash ; Gorantla, Ramakrishna S. ; Uppal, Hardeep ; Lavu, N. ; Potluri, Rahul. / Angioplasty improves mortality in the managment of acute coronary syndrome in patients with chronic anaemia. In: Cardiology. 2015 ; Vol. 132, No. supp 1. pp. 278.
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    title = "Angioplasty improves mortality in the managment of acute coronary syndrome in patients with chronic anaemia",
    abstract = "Aims: Angioplasty has changed the management of acute coronary syndromes (ACS). However,in patients with chronic anaemia the evidence for angioplasty in ACS is less well known. Wesought to investigate the role of angioplasty in patients with anaemia presenting with ACS, andhow it affected mortality.Method: Anonymous information on patients with ACS, attending a large multi-ethnic generalhospital in Manchester, United Kingdom in the period 2000-2013 was obtained from the localhealth authority computerised hospital activity analysis register using ICD-10 and OPCS codingsystems according to the ACALM protocol.Results: Out of 25294 patients, 1551(6.1{\%}) patients had Anaemia as defined by nationalstandards. Of these, 89(5.7{\%}) patients underwent angioplasty with mean age 65.0 years andwere significantly younger than patients who did not undergo angioplasty. Patients who did notundergo angioplasty had higher prevalence of Ischaemic Stroke(6.2{\%} vs 1.1{\%}), HeartFailure(36.7{\%} vs 11.2{\%}) and Chronic Kidney Disease(18.7{\%} vs 4.5{\%}), whilst angioplastypatients had higher prevalence of previous ACS (27.2{\%} vs 36.0{\%}) and peripheral vasculardisease(6.8{\%} vs 7.9{\%}). Multi-nominal logistic regression analysis revealed HeartFailure(RR2.16), Ischaemic Stroke(RR3.67) and Chronic Kidney Disease(RR1.39) as significantpredictors of mortality in this patient group. Angioplasty(RR7.81) and previous ACS(RR1.88)conferred mortality improvement in this patient group.",
    author = "Mahvash Zaman and Gorantla, {Ramakrishna S.} and Hardeep Uppal and N. Lavu and Rahul Potluri",
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    Zaman, M, Gorantla, RS, Uppal, H, Lavu, N & Potluri, R 2015, 'Angioplasty improves mortality in the managment of acute coronary syndrome in patients with chronic anaemia', Cardiology, vol. 132, no. supp 1, 358, pp. 278. https://doi.org/10.1159/000442375

    Angioplasty improves mortality in the managment of acute coronary syndrome in patients with chronic anaemia. / Zaman, Mahvash; Gorantla, Ramakrishna S.; Uppal, Hardeep; Lavu, N.; Potluri, Rahul.

    In: Cardiology, Vol. 132, No. supp 1, 358, 29.11.2015, p. 278.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Angioplasty improves mortality in the managment of acute coronary syndrome in patients with chronic anaemia

    AU - Zaman, Mahvash

    AU - Gorantla, Ramakrishna S.

    AU - Uppal, Hardeep

    AU - Lavu, N.

    AU - Potluri, Rahul

    N1 - 11th International Congress on Coronary Artery Disease (ICCAD), Florence, Italy November 29 - December 2, 2015: Abstracts

    PY - 2015/11/29

    Y1 - 2015/11/29

    N2 - Aims: Angioplasty has changed the management of acute coronary syndromes (ACS). However,in patients with chronic anaemia the evidence for angioplasty in ACS is less well known. Wesought to investigate the role of angioplasty in patients with anaemia presenting with ACS, andhow it affected mortality.Method: Anonymous information on patients with ACS, attending a large multi-ethnic generalhospital in Manchester, United Kingdom in the period 2000-2013 was obtained from the localhealth authority computerised hospital activity analysis register using ICD-10 and OPCS codingsystems according to the ACALM protocol.Results: Out of 25294 patients, 1551(6.1%) patients had Anaemia as defined by nationalstandards. Of these, 89(5.7%) patients underwent angioplasty with mean age 65.0 years andwere significantly younger than patients who did not undergo angioplasty. Patients who did notundergo angioplasty had higher prevalence of Ischaemic Stroke(6.2% vs 1.1%), HeartFailure(36.7% vs 11.2%) and Chronic Kidney Disease(18.7% vs 4.5%), whilst angioplastypatients had higher prevalence of previous ACS (27.2% vs 36.0%) and peripheral vasculardisease(6.8% vs 7.9%). Multi-nominal logistic regression analysis revealed HeartFailure(RR2.16), Ischaemic Stroke(RR3.67) and Chronic Kidney Disease(RR1.39) as significantpredictors of mortality in this patient group. Angioplasty(RR7.81) and previous ACS(RR1.88)conferred mortality improvement in this patient group.

    AB - Aims: Angioplasty has changed the management of acute coronary syndromes (ACS). However,in patients with chronic anaemia the evidence for angioplasty in ACS is less well known. Wesought to investigate the role of angioplasty in patients with anaemia presenting with ACS, andhow it affected mortality.Method: Anonymous information on patients with ACS, attending a large multi-ethnic generalhospital in Manchester, United Kingdom in the period 2000-2013 was obtained from the localhealth authority computerised hospital activity analysis register using ICD-10 and OPCS codingsystems according to the ACALM protocol.Results: Out of 25294 patients, 1551(6.1%) patients had Anaemia as defined by nationalstandards. Of these, 89(5.7%) patients underwent angioplasty with mean age 65.0 years andwere significantly younger than patients who did not undergo angioplasty. Patients who did notundergo angioplasty had higher prevalence of Ischaemic Stroke(6.2% vs 1.1%), HeartFailure(36.7% vs 11.2%) and Chronic Kidney Disease(18.7% vs 4.5%), whilst angioplastypatients had higher prevalence of previous ACS (27.2% vs 36.0%) and peripheral vasculardisease(6.8% vs 7.9%). Multi-nominal logistic regression analysis revealed HeartFailure(RR2.16), Ischaemic Stroke(RR3.67) and Chronic Kidney Disease(RR1.39) as significantpredictors of mortality in this patient group. Angioplasty(RR7.81) and previous ACS(RR1.88)conferred mortality improvement in this patient group.

    U2 - 10.1159/000442375

    DO - 10.1159/000442375

    M3 - Article

    VL - 132

    SP - 278

    JO - Cardiology

    JF - Cardiology

    SN - 0008-6312

    IS - supp 1

    M1 - 358

    ER -