Animal model of the short-term cardiorespiratory effects of intermittent vagus nerve stimulation

Boubker Zaaimi; Reinhard Grebe; Fabrice Wallois

doi:10.1016/j.autneu.2008.07.002

Animal model of the short-term cardiorespiratory effects of intermittent vagus nerve stimulation

Boubker Zaaimi^*
, Reinhard Grebe
, Fabrice Wallois

^*Corresponding author for this work

University of Picardy
CHU Nord

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Purpose: To develop an animal model of the effects of vagus nerve stimulation (VNS) on heart rate and respiration in studies of seizure treatment. Methods: Nine rats implanted with ECG, EMG, and VNS electrodes and pulse generator were stimulated with 81 different sets of parameters while they slept in a plethysmographic box. Result: From cardiorespiratory effects of VNS, an index (α) was found to distinguish between weak and strong VNS doses. Weak VNS dose induced an increase in respiratory frequency and no significant change in heart rate. The effect of VNS on respiration, similar to that observed in children, can be divided into 3 phases. Strong VNS dose induced a decrease in respiratory frequency concomitant with a decrease in heart rate. Increasing the intensity of the VNS induced a proportional increase in the maximal inspiratory strength. Conclusion: Various VNS parameter settings induce different and concomitant cardiorespiratory variations in conscious sleeping rats. These effects correlate with the intensity of the VNS parameters. Understanding the effects of the intensity of VNS parameters may allow for further optimization of VNS parameters in patients receiving VNS.

Original language	English
Pages (from-to)	20-26
Number of pages	7
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	143
Issue number	1-2
DOIs	https://doi.org/10.1016/j.autneu.2008.07.002
Publication status	Published - 5 Dec 2008

Funding

This study was supported by grants from University of Picardie Jules Verne, Amiens North University Hospital, La Fondation de l'Avenir (France) and Cyberonics @, EU. We thank Mr. Aleksander Lodwich and Dr. Nicolas Voituron for all of their help. We are very grateful to Dr. Claire Witham in Prof. Stuart Baker’s Motor control laboratory in Newcastle for English language corrections. We would like to thank Dr. Johnny Roughan and Dr. Paul Flecknell in Newcastle Upon Tyne for their help in administration of analgesia.

Keywords

Conscious rats
Heart rate
Respiration
Vagus nerve stimulation

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10.1016/j.autneu.2008.07.002

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title = "Animal model of the short-term cardiorespiratory effects of intermittent vagus nerve stimulation",

abstract = "Purpose: To develop an animal model of the effects of vagus nerve stimulation (VNS) on heart rate and respiration in studies of seizure treatment. Methods: Nine rats implanted with ECG, EMG, and VNS electrodes and pulse generator were stimulated with 81 different sets of parameters while they slept in a plethysmographic box. Result: From cardiorespiratory effects of VNS, an index (α) was found to distinguish between weak and strong VNS doses. Weak VNS dose induced an increase in respiratory frequency and no significant change in heart rate. The effect of VNS on respiration, similar to that observed in children, can be divided into 3 phases. Strong VNS dose induced a decrease in respiratory frequency concomitant with a decrease in heart rate. Increasing the intensity of the VNS induced a proportional increase in the maximal inspiratory strength. Conclusion: Various VNS parameter settings induce different and concomitant cardiorespiratory variations in conscious sleeping rats. These effects correlate with the intensity of the VNS parameters. Understanding the effects of the intensity of VNS parameters may allow for further optimization of VNS parameters in patients receiving VNS.",

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author = "Boubker Zaaimi and Reinhard Grebe and Fabrice Wallois",

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doi = "10.1016/j.autneu.2008.07.002",

language = "English",

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T1 - Animal model of the short-term cardiorespiratory effects of intermittent vagus nerve stimulation

AU - Zaaimi, Boubker

AU - Grebe, Reinhard

AU - Wallois, Fabrice

PY - 2008/12/5

Y1 - 2008/12/5

N2 - Purpose: To develop an animal model of the effects of vagus nerve stimulation (VNS) on heart rate and respiration in studies of seizure treatment. Methods: Nine rats implanted with ECG, EMG, and VNS electrodes and pulse generator were stimulated with 81 different sets of parameters while they slept in a plethysmographic box. Result: From cardiorespiratory effects of VNS, an index (α) was found to distinguish between weak and strong VNS doses. Weak VNS dose induced an increase in respiratory frequency and no significant change in heart rate. The effect of VNS on respiration, similar to that observed in children, can be divided into 3 phases. Strong VNS dose induced a decrease in respiratory frequency concomitant with a decrease in heart rate. Increasing the intensity of the VNS induced a proportional increase in the maximal inspiratory strength. Conclusion: Various VNS parameter settings induce different and concomitant cardiorespiratory variations in conscious sleeping rats. These effects correlate with the intensity of the VNS parameters. Understanding the effects of the intensity of VNS parameters may allow for further optimization of VNS parameters in patients receiving VNS.

AB - Purpose: To develop an animal model of the effects of vagus nerve stimulation (VNS) on heart rate and respiration in studies of seizure treatment. Methods: Nine rats implanted with ECG, EMG, and VNS electrodes and pulse generator were stimulated with 81 different sets of parameters while they slept in a plethysmographic box. Result: From cardiorespiratory effects of VNS, an index (α) was found to distinguish between weak and strong VNS doses. Weak VNS dose induced an increase in respiratory frequency and no significant change in heart rate. The effect of VNS on respiration, similar to that observed in children, can be divided into 3 phases. Strong VNS dose induced a decrease in respiratory frequency concomitant with a decrease in heart rate. Increasing the intensity of the VNS induced a proportional increase in the maximal inspiratory strength. Conclusion: Various VNS parameter settings induce different and concomitant cardiorespiratory variations in conscious sleeping rats. These effects correlate with the intensity of the VNS parameters. Understanding the effects of the intensity of VNS parameters may allow for further optimization of VNS parameters in patients receiving VNS.

KW - Conscious rats

KW - Heart rate

KW - Respiration

KW - Vagus nerve stimulation

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ER -

Animal model of the short-term cardiorespiratory effects of intermittent vagus nerve stimulation

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