Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c Nude mouse model involves activation of the cell antioxidant system

D. Dolgova, T. Abakumova, T. Gening, L. Poludnyakova, Igor Zolotovskii, Dmitrii Stoliarov, Andrei A. Fotiadi, Anna Khokhlova, Edik U. Rafailov, Sergei Sokolovski

Research output: Contribution to journalArticle

Abstract

Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology. Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body. The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band. Therefore, PBM effects on a model organism within this spectrum range are of particular interest for preclinical research. Here, we report comprehensive biomolecular studies of the changes in the BALB/c nude mice skin after an exposure to the continuous laser radiation at the 1270 nm wavelength and energy densities of 0.12 and 1.2 J/cm2. Such regime induces both local and systemic PBM effects, presumably due to the short-term increase in ROS levels, which in turn activate the cell antioxidative system.
Original languageEnglish
Pages (from-to)4261-4275
Number of pages15
JournalBiomedical Optics Express
Volume10
Issue number8
DOIs
Publication statusPublished - 31 Jul 2019

Fingerprint

antioxidants
Nude Mice
mice
Lasers
Anti-Inflammatory Agents
Antioxidants
activation
irradiation
cells
wavelengths
laser beams
lasers
Radiation
organisms
flux density
cancer
disorders
Autoimmune Diseases
absorption spectra
Research Personnel

Bibliographical note

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Funding: Ministry of Education and Science of the Russian Federation (Government Assignment #3.3889.2017(I.Z., D.S., A.F., A.Kh.)). Russian Science Foundation (RSF) (# 18-15-00172 (E.R.)). EU H2020 FET research and innovation program MESO-BRAIN (#713140 (E.R., S.S.)). Leverhulme Trust (#VP2-2016-042, Visiting Professorship, Aston University (A.F.)).

Keywords

  • BALB/c Nude mice
  • photobiomodulation
  • low-level lasers, 1270 nm
  • cell proliferation
  • cell antioxidant system

Cite this

Dolgova, D. ; Abakumova, T. ; Gening, T. ; Poludnyakova, L. ; Zolotovskii, Igor ; Stoliarov, Dmitrii ; Fotiadi, Andrei A. ; Khokhlova, Anna ; Rafailov, Edik U. ; Sokolovski, Sergei. / Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c Nude mouse model involves activation of the cell antioxidant system. In: Biomedical Optics Express. 2019 ; Vol. 10, No. 8. pp. 4261-4275.
@article{415f746da70c425eacb2f0b227120a6f,
title = "Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c Nude mouse model involves activation of the cell antioxidant system",
abstract = "Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology. Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body. The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band. Therefore, PBM effects on a model organism within this spectrum range are of particular interest for preclinical research. Here, we report comprehensive biomolecular studies of the changes in the BALB/c nude mice skin after an exposure to the continuous laser radiation at the 1270 nm wavelength and energy densities of 0.12 and 1.2 J/cm2. Such regime induces both local and systemic PBM effects, presumably due to the short-term increase in ROS levels, which in turn activate the cell antioxidative system.",
keywords = "BALB/c Nude mice, photobiomodulation, low-level lasers, 1270 nm, cell proliferation, cell antioxidant system",
author = "D. Dolgova and T. Abakumova and T. Gening and L. Poludnyakova and Igor Zolotovskii and Dmitrii Stoliarov and Fotiadi, {Andrei A.} and Anna Khokhlova and Rafailov, {Edik U.} and Sergei Sokolovski",
note = "{\circledC} 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement Funding: Ministry of Education and Science of the Russian Federation (Government Assignment #3.3889.2017(I.Z., D.S., A.F., A.Kh.)). Russian Science Foundation (RSF) (# 18-15-00172 (E.R.)). EU H2020 FET research and innovation program MESO-BRAIN (#713140 (E.R., S.S.)). Leverhulme Trust (#VP2-2016-042, Visiting Professorship, Aston University (A.F.)).",
year = "2019",
month = "7",
day = "31",
doi = "10.1364/BOE.10.004261",
language = "English",
volume = "10",
pages = "4261--4275",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "8",

}

Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c Nude mouse model involves activation of the cell antioxidant system. / Dolgova, D.; Abakumova, T.; Gening, T.; Poludnyakova, L.; Zolotovskii, Igor; Stoliarov, Dmitrii; Fotiadi, Andrei A.; Khokhlova, Anna; Rafailov, Edik U.; Sokolovski, Sergei.

In: Biomedical Optics Express, Vol. 10, No. 8, 31.07.2019, p. 4261-4275.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c Nude mouse model involves activation of the cell antioxidant system

AU - Dolgova, D.

AU - Abakumova, T.

AU - Gening, T.

AU - Poludnyakova, L.

AU - Zolotovskii, Igor

AU - Stoliarov, Dmitrii

AU - Fotiadi, Andrei A.

AU - Khokhlova, Anna

AU - Rafailov, Edik U.

AU - Sokolovski, Sergei

N1 - © 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement Funding: Ministry of Education and Science of the Russian Federation (Government Assignment #3.3889.2017(I.Z., D.S., A.F., A.Kh.)). Russian Science Foundation (RSF) (# 18-15-00172 (E.R.)). EU H2020 FET research and innovation program MESO-BRAIN (#713140 (E.R., S.S.)). Leverhulme Trust (#VP2-2016-042, Visiting Professorship, Aston University (A.F.)).

PY - 2019/7/31

Y1 - 2019/7/31

N2 - Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology. Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body. The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band. Therefore, PBM effects on a model organism within this spectrum range are of particular interest for preclinical research. Here, we report comprehensive biomolecular studies of the changes in the BALB/c nude mice skin after an exposure to the continuous laser radiation at the 1270 nm wavelength and energy densities of 0.12 and 1.2 J/cm2. Such regime induces both local and systemic PBM effects, presumably due to the short-term increase in ROS levels, which in turn activate the cell antioxidative system.

AB - Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology. Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body. The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band. Therefore, PBM effects on a model organism within this spectrum range are of particular interest for preclinical research. Here, we report comprehensive biomolecular studies of the changes in the BALB/c nude mice skin after an exposure to the continuous laser radiation at the 1270 nm wavelength and energy densities of 0.12 and 1.2 J/cm2. Such regime induces both local and systemic PBM effects, presumably due to the short-term increase in ROS levels, which in turn activate the cell antioxidative system.

KW - BALB/c Nude mice

KW - photobiomodulation

KW - low-level lasers, 1270 nm

KW - cell proliferation

KW - cell antioxidant system

UR - https://www.osapublishing.org/boe/abstract.cfm?uri=boe-10-8-4261

UR - http://www.scopus.com/inward/record.url?scp=85071036775&partnerID=8YFLogxK

U2 - 10.1364/BOE.10.004261

DO - 10.1364/BOE.10.004261

M3 - Article

VL - 10

SP - 4261

EP - 4275

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 8

ER -