Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus

Sameer Joshi, Atul A Chaudhari, Vida Dennis, Daniel J Kirby, Yvonne Perrie, Shree Ram Singh

Research output: Contribution to journalArticle

Abstract

Although respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infection in infants and adults, effective treatment options remain limited. To circumvent this issue, there is a novel approach, namely, the development of multifunctional liposomes for the delivery of anti RSV-peptides. While most of the peptides that are used for loading with the particulate delivery systems are the penetrating peptides, an alternative approach is the development of liposome-peptide systems, which are loaded with an RSV fusion peptide (RF-482), which has been designed to inhibit the RSV fusion and block infection. The results of this work have revealed that the liposomes themselves can serve as potential RSV inhibitors, whilst the anti-RSV-peptide with liposomes can significantly increase the RSV inhibition when compared with the anti-RSV peptide alone.

LanguageEnglish
Article number37
JournalBioengineering (Basel, Switzerland)
Volume5
Issue number2
DOIs
Publication statusPublished - 9 May 2018

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Liposomes
Viruses
Peptides
Fusion reactions

Bibliographical note

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

  • liposomes
  • respiratory syncytial viru
  • peptide
  • hydrophilic

Cite this

Joshi, Sameer ; Chaudhari, Atul A ; Dennis, Vida ; Kirby, Daniel J ; Perrie, Yvonne ; Singh, Shree Ram. / Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus. 2018 ; Vol. 5, No. 2.
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Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus. / Joshi, Sameer; Chaudhari, Atul A; Dennis, Vida; Kirby, Daniel J; Perrie, Yvonne; Singh, Shree Ram.

Vol. 5, No. 2, 37, 09.05.2018.

Research output: Contribution to journalArticle

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