Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus

Sameer Joshi; Atul A Chaudhari; Vida Dennis; Daniel J Kirby; Yvonne Perrie; Shree Ram Singh

doi:10.3390/bioengineering5020037

Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus

Sameer Joshi, Atul A Chaudhari, Vida Dennis, Daniel J Kirby, Yvonne Perrie, Shree Ram Singh

Research output: Contribution to journal › Article › peer-review

Abstract

Although respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infection in infants and adults, effective treatment options remain limited. To circumvent this issue, there is a novel approach, namely, the development of multifunctional liposomes for the delivery of anti RSV-peptides. While most of the peptides that are used for loading with the particulate delivery systems are the penetrating peptides, an alternative approach is the development of liposome-peptide systems, which are loaded with an RSV fusion peptide (RF-482), which has been designed to inhibit the RSV fusion and block infection. The results of this work have revealed that the liposomes themselves can serve as potential RSV inhibitors, whilst the anti-RSV-peptide with liposomes can significantly increase the RSV inhibition when compared with the anti-RSV peptide alone.

Original language	English
Article number	37
Journal	Bioengineering (Basel, Switzerland)
Volume	5
Issue number	2
DOIs	https://doi.org/10.3390/bioengineering5020037
Publication status	Published - 9 May 2018

Bibliographical note

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

liposomes
respiratory syncytial viru
peptide
hydrophilic

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10.3390/bioengineering5020037Licence: CC BY 3.0

Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 2.4 MBLicence: CC BY 3.0

Cite this

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title = "Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus",

abstract = "Although respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infection in infants and adults, effective treatment options remain limited. To circumvent this issue, there is a novel approach, namely, the development of multifunctional liposomes for the delivery of anti RSV-peptides. While most of the peptides that are used for loading with the particulate delivery systems are the penetrating peptides, an alternative approach is the development of liposome-peptide systems, which are loaded with an RSV fusion peptide (RF-482), which has been designed to inhibit the RSV fusion and block infection. The results of this work have revealed that the liposomes themselves can serve as potential RSV inhibitors, whilst the anti-RSV-peptide with liposomes can significantly increase the RSV inhibition when compared with the anti-RSV peptide alone.",

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AU - Joshi, Sameer

AU - Chaudhari, Atul A

AU - Dennis, Vida

AU - Kirby, Daniel J

AU - Perrie, Yvonne

AU - Singh, Shree Ram

N1 - © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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N2 - Although respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infection in infants and adults, effective treatment options remain limited. To circumvent this issue, there is a novel approach, namely, the development of multifunctional liposomes for the delivery of anti RSV-peptides. While most of the peptides that are used for loading with the particulate delivery systems are the penetrating peptides, an alternative approach is the development of liposome-peptide systems, which are loaded with an RSV fusion peptide (RF-482), which has been designed to inhibit the RSV fusion and block infection. The results of this work have revealed that the liposomes themselves can serve as potential RSV inhibitors, whilst the anti-RSV-peptide with liposomes can significantly increase the RSV inhibition when compared with the anti-RSV peptide alone.

AB - Although respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infection in infants and adults, effective treatment options remain limited. To circumvent this issue, there is a novel approach, namely, the development of multifunctional liposomes for the delivery of anti RSV-peptides. While most of the peptides that are used for loading with the particulate delivery systems are the penetrating peptides, an alternative approach is the development of liposome-peptide systems, which are loaded with an RSV fusion peptide (RF-482), which has been designed to inhibit the RSV fusion and block infection. The results of this work have revealed that the liposomes themselves can serve as potential RSV inhibitors, whilst the anti-RSV-peptide with liposomes can significantly increase the RSV inhibition when compared with the anti-RSV peptide alone.

KW - liposomes

KW - respiratory syncytial viru

KW - peptide

KW - hydrophilic

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DO - 10.3390/bioengineering5020037

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JO - Bioengineering (Basel, Switzerland)

JF - Bioengineering (Basel, Switzerland)

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ER -

Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus

Abstract

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Keywords

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