Antibacterial activity of 3-substituted pyrrole-2,5-diones against Pseudomonas aeruginosa

Eric Lattmann; Simon Dunn; Suwanna Niamsanit; Jintana Sattayasai; Nison Sattayasai

doi:10.2174/157018007781788570

Antibacterial activity of 3-substituted pyrrole-2,5-diones against Pseudomonas aeruginosa

Eric Lattmann^*, Simon Dunn, Suwanna Niamsanit, Jintana Sattayasai, Nison Sattayasai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

3-Substituted pyrrole-2,5-diones were synthesised from mucohalogen acids and the antibacterial activity was subsequently determined in biological assays. The minimum inhibitory concentration and the minimum bactericidal concentration of 2a were determined for a wide range of microorganisms in the low micromolar range. Protein identification using SDS-PAGE and LC/MS/MS demonstrated a partly degradation of OprF-related proteins giving an insight into the underlying mechanism of these novel antibacterial agents. © 2007 Bentham Science Publishers Ltd.

Original language	English
Pages (from-to)	513-519
Number of pages	7
Journal	Letters in Drug Design and Discovery
Volume	4
Issue number	7
DOIs	https://doi.org/10.2174/157018007781788570
Publication status	Published - Oct 2007

Keywords

antibacterial
halogenated pyrrole
oprF-related protein
pseudomonas aeruginosa

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abstract = "3-Substituted pyrrole-2,5-diones were synthesised from mucohalogen acids and the antibacterial activity was subsequently determined in biological assays. The minimum inhibitory concentration and the minimum bactericidal concentration of 2a were determined for a wide range of microorganisms in the low micromolar range. Protein identification using SDS-PAGE and LC/MS/MS demonstrated a partly degradation of OprF-related proteins giving an insight into the underlying mechanism of these novel antibacterial agents. {\textcopyright} 2007 Bentham Science Publishers Ltd.",

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AU - Lattmann, Eric

AU - Dunn, Simon

AU - Niamsanit, Suwanna

AU - Sattayasai, Jintana

AU - Sattayasai, Nison

PY - 2007/10

Y1 - 2007/10

N2 - 3-Substituted pyrrole-2,5-diones were synthesised from mucohalogen acids and the antibacterial activity was subsequently determined in biological assays. The minimum inhibitory concentration and the minimum bactericidal concentration of 2a were determined for a wide range of microorganisms in the low micromolar range. Protein identification using SDS-PAGE and LC/MS/MS demonstrated a partly degradation of OprF-related proteins giving an insight into the underlying mechanism of these novel antibacterial agents. © 2007 Bentham Science Publishers Ltd.

AB - 3-Substituted pyrrole-2,5-diones were synthesised from mucohalogen acids and the antibacterial activity was subsequently determined in biological assays. The minimum inhibitory concentration and the minimum bactericidal concentration of 2a were determined for a wide range of microorganisms in the low micromolar range. Protein identification using SDS-PAGE and LC/MS/MS demonstrated a partly degradation of OprF-related proteins giving an insight into the underlying mechanism of these novel antibacterial agents. © 2007 Bentham Science Publishers Ltd.

KW - antibacterial

KW - halogenated pyrrole

KW - oprF-related protein

KW - pseudomonas aeruginosa

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UR - http://www.eurekaselect.com/78826/article

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DO - 10.2174/157018007781788570

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SP - 513

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JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

IS - 7

ER -

Antibacterial activity of 3-substituted pyrrole-2,5-diones against Pseudomonas aeruginosa

Abstract

Keywords

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