Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function

Malcolm J. Jackson*, Sergio Papa, Juan Bolaños, Richard Bruckdorfer, Harald Carlsen, Ruan M Elliott, Jacoba Flier, Helen R. Griffiths, Simon Heales, Birgit Holst, Michele Lorusso, Elizabeth Lund, Jan Øivind Moskaug, Ulrich Moser, Marco Di Paola, M Cristina Polidori, Anna Signorile, Wilhelm Stahl, José Viña-Ribes, Siân B. Astley

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Redox-sensitive cell signalling Thiol groups and the regulation of gene expression Redox-sensitive signal transduction pathways Protein kinases Protein phosphatases Lipids and phospholipases Antioxidant (electrophile) response element Intracellular calcium signalling Transcription factors NF-?B AP-1 p53 Cellular responses to oxidative stress Cellular responses to change in redox state Proliferation Cell death Immune cell function Reactive oxygen and nitrogen species – good or bad? Reactive oxygen species and cell death Reactive oxygen species and inflammation Are specific reactive oxygen species and antioxidants involved in modulating cellular responses? Specific effects of dietary antioxidants in cell regulation Carotenoids Vitamin E Flavonoids Inducers of phase II enzymes Disease states affected Oxidants, antioxidants and mitochondria Introduction Mitochondrial generation of reactive oxygen and nitrogen species Mitochondria and apoptosis Mitochondria and antioxidant defences Key role of mitochondrial GSH in the defence against oxidative damage Mitochondrial oxidative damage Direct oxidative damage to the mitochondrial electron transport chain Nitric oxide and damage to mitochondria Effects of nutrients on mitochondria Caloric restriction and antioxidants Lipids Antioxidants Techniques and approaches Mitochondrial techniques cDNA microarray approaches Proteomics approaches Transgenic mice as tools in antioxidant research Gene knockout and over expression Transgenic reporter mice Conclusions Future research needs
Original languageEnglish
Pages (from-to)209-285
Number of pages77
JournalMolecular Aspects of Medicine
Volume23
Issue number1-3
DOIs
Publication statusPublished - Feb 2002

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    Jackson, M. J., Papa, S., Bolaños, J., Bruckdorfer, R., Carlsen, H., Elliott, R. M., Flier, J., Griffiths, H. R., Heales, S., Holst, B., Lorusso, M., Lund, E., Øivind Moskaug, J., Moser, U., Di Paola, M., Polidori, M. C., Signorile, A., Stahl, W., Viña-Ribes, J., & Astley, S. B. (2002). Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function. Molecular Aspects of Medicine, 23(1-3), 209-285. https://doi.org/10.1016/S0098-2997(02)00018-3