Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy): possible pathomechanism of human cervical compressive myelopathy

Kenzo Uchida, Hideaki Nakajima, Shuji Watanabe, Takafumi Yayama, Alexander R. Guerrero, Tomoo Inukai, Takayuki Hirai, Daisuke Sugita, William E Johnson, Hisatoshi Baba

Research output: Contribution to journalArticlepeer-review

Abstract

Cervical compressive myelopathy is the most serious complication of cervical spondylosis or ossification of the posterior longitudinal ligament (OPLL) and the most frequent cause of spinal cord dysfunction. There is little information on the exact pathophysiological mechanism responsible for the progressive loss of neural tissue in the spinal cord of such patients. In this study, we used the spinal hyperostotic mouse (twy/twy) as a suitable model of human spondylosis, and OPLL to investigate the cellular and molecular changes in the spinal cord. Mutant twy/twy mouse developed ossification of the ligamentum flavum at C2-C3 and exhibited progressive paralysis.
Original languageEnglish
Pages (from-to)490-497
Number of pages8
JournalEuropean Spine Journal
Volume21
Issue number3
DOIs
Publication statusPublished - Mar 2012

Bibliographical note

Creative Commons Attribution. © The Author(s) 2011.
The original publication is available at www.springerlink.com

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