Application of optical non-invasive methods to diagnose the state of the lower limb tissues in patients with diabetes mellitus

E. V. Zharkikh; V. V. Dremin; M. A. Filina; I. N. Makovik; E. V. Potapova; E. A. Zherebtsov; A. I. Zherebtsova; A. V. Dunaev

doi:10.1088/1742-6596/929/1/012069

Application of optical non-invasive methods to diagnose the state of the lower limb tissues in patients with diabetes mellitus

E. V. Zharkikh^*, V. V. Dremin, M. A. Filina, I. N. Makovik, E. V. Potapova, E. A. Zherebtsov, A. I. Zherebtsova, A. V. Dunaev

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

Abstract

The paper shows the possibility of assessing the functional state of microcirculatory-tissue systems of patients with diabetes mellitus by laser Doppler flowmetry (LDF), diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS) methods. A review of the existing non-invasive optical technologies used to assess the state of microcirculation and oxygen metabolism in tissues of patients with diabetes is conducted. A series of experimental studies involving 76 patients with diabetes and 46 healthy volunteers was carried out. A wavelet analysis of LDF-grams was used to evaluate the adaptive changes of microcirculation during the temperature tests. The obtained data revealed that the proposed methodology in the form of combined use of several diagnostic technologies (LDF, FS and DRS) allows us to detect the presence or absence of trophic disorders and to evaluate adaptation processes during thermal tests.

Original language	English
Article number	012069
Journal	Journal of Physics: Conference Series
Volume	929
Issue number	1
DOIs	https://doi.org/10.1088/1742-6596/929/1/012069
Publication status	Published - 27 Nov 2017
Event	International Conference PhysicA.SPb 2016 - Saint-Petersburg, Russian Federation Duration: 1 Nov 2016 → 3 Nov 2016

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of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI

Funding Information:
This work was supported by grant of the President of the Russian Federation for state support of young Russian scientists + MK-7168.2016.8.

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10.1088/1742-6596/929/1/012069

Application of optical non-invasive methods
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Zharkikh, E. V., Dremin, V. V., Filina, M. A., Makovik, I. N., Potapova, E. V., Zherebtsov, E. A., Zherebtsova, A. I., & Dunaev, A. V. (2017). Application of optical non-invasive methods to diagnose the state of the lower limb tissues in patients with diabetes mellitus. Journal of Physics: Conference Series, 929(1), Article 012069. https://doi.org/10.1088/1742-6596/929/1/012069

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abstract = "The paper shows the possibility of assessing the functional state of microcirculatory-tissue systems of patients with diabetes mellitus by laser Doppler flowmetry (LDF), diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS) methods. A review of the existing non-invasive optical technologies used to assess the state of microcirculation and oxygen metabolism in tissues of patients with diabetes is conducted. A series of experimental studies involving 76 patients with diabetes and 46 healthy volunteers was carried out. A wavelet analysis of LDF-grams was used to evaluate the adaptive changes of microcirculation during the temperature tests. The obtained data revealed that the proposed methodology in the form of combined use of several diagnostic technologies (LDF, FS and DRS) allows us to detect the presence or absence of trophic disorders and to evaluate adaptation processes during thermal tests.",

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note = "Content from this work may be used under the terms of theCreative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI Funding Information: This work was supported by grant of the President of the Russian Federation for state support of young Russian scientists + MK-7168.2016.8. ; International Conference PhysicA.SPb 2016 ; Conference date: 01-11-2016 Through 03-11-2016",

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AU - Zharkikh, E. V.

AU - Dremin, V. V.

AU - Filina, M. A.

AU - Makovik, I. N.

AU - Potapova, E. V.

AU - Zherebtsov, E. A.

AU - Zherebtsova, A. I.

AU - Dunaev, A. V.

N1 - Content from this work may be used under the terms of theCreative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI Funding Information: This work was supported by grant of the President of the Russian Federation for state support of young Russian scientists + MK-7168.2016.8.

PY - 2017/11/27

Y1 - 2017/11/27

N2 - The paper shows the possibility of assessing the functional state of microcirculatory-tissue systems of patients with diabetes mellitus by laser Doppler flowmetry (LDF), diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS) methods. A review of the existing non-invasive optical technologies used to assess the state of microcirculation and oxygen metabolism in tissues of patients with diabetes is conducted. A series of experimental studies involving 76 patients with diabetes and 46 healthy volunteers was carried out. A wavelet analysis of LDF-grams was used to evaluate the adaptive changes of microcirculation during the temperature tests. The obtained data revealed that the proposed methodology in the form of combined use of several diagnostic technologies (LDF, FS and DRS) allows us to detect the presence or absence of trophic disorders and to evaluate adaptation processes during thermal tests.

AB - The paper shows the possibility of assessing the functional state of microcirculatory-tissue systems of patients with diabetes mellitus by laser Doppler flowmetry (LDF), diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS) methods. A review of the existing non-invasive optical technologies used to assess the state of microcirculation and oxygen metabolism in tissues of patients with diabetes is conducted. A series of experimental studies involving 76 patients with diabetes and 46 healthy volunteers was carried out. A wavelet analysis of LDF-grams was used to evaluate the adaptive changes of microcirculation during the temperature tests. The obtained data revealed that the proposed methodology in the form of combined use of several diagnostic technologies (LDF, FS and DRS) allows us to detect the presence or absence of trophic disorders and to evaluate adaptation processes during thermal tests.

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JO - Journal of Physics: Conference Series

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T2 - International Conference PhysicA.SPb 2016

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ER -

Application of optical non-invasive methods to diagnose the state of the lower limb tissues in patients with diabetes mellitus

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