Application of optical non-invasive methods to diagnose the state of the lower limb tissues in patients with diabetes mellitus

E. V. Zharkikh*, V. V. Dremin, M. A. Filina, I. N. Makovik, E. V. Potapova, E. A. Zherebtsov, A. I. Zherebtsova, A. V. Dunaev

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


The paper shows the possibility of assessing the functional state of microcirculatory-tissue systems of patients with diabetes mellitus by laser Doppler flowmetry (LDF), diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS) methods. A review of the existing non-invasive optical technologies used to assess the state of microcirculation and oxygen metabolism in tissues of patients with diabetes is conducted. A series of experimental studies involving 76 patients with diabetes and 46 healthy volunteers was carried out. A wavelet analysis of LDF-grams was used to evaluate the adaptive changes of microcirculation during the temperature tests. The obtained data revealed that the proposed methodology in the form of combined use of several diagnostic technologies (LDF, FS and DRS) allows us to detect the presence or absence of trophic disorders and to evaluate adaptation processes during thermal tests.

Original languageEnglish
Article number012069
JournalJournal of Physics: Conference Series
Issue number1
Publication statusPublished - 27 Nov 2017
EventInternational Conference PhysicA.SPb 2016 - Saint-Petersburg, Russian Federation
Duration: 1 Nov 20163 Nov 2016

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Funding Information:
This work was supported by grant of the President of the Russian Federation for state support of young Russian scientists + MK-7168.2016.8.


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