The paper shows the possibility of assessing the functional state of microcirculatory-tissue systems of patients with diabetes mellitus by laser Doppler flowmetry (LDF), diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS) methods. A review of the existing non-invasive optical technologies used to assess the state of microcirculation and oxygen metabolism in tissues of patients with diabetes is conducted. A series of experimental studies involving 76 patients with diabetes and 46 healthy volunteers was carried out. A wavelet analysis of LDF-grams was used to evaluate the adaptive changes of microcirculation during the temperature tests. The obtained data revealed that the proposed methodology in the form of combined use of several diagnostic technologies (LDF, FS and DRS) allows us to detect the presence or absence of trophic disorders and to evaluate adaptation processes during thermal tests.
|Journal of Physics: Conference Series
|Published - 27 Nov 2017
|International Conference PhysicA.SPb 2016 - Saint-Petersburg, Russian Federation
Duration: 1 Nov 2016 → 3 Nov 2016
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This work was supported by grant of the President of the Russian Federation for state support of young Russian scientists + MK-7168.2016.8.