A series of surface plasmonic fibre devices were fabricated using multiple coatings deposited on a lapped section of a single mode fibre and post-fabrication UV laser irradiation processing with a phase mask, producing a surface relief grating structure. These devices showed high spectral sensitivity in the aqueous index regime ranging up to 4000 nm/RIU for wavelength and 800 dB/RIU for intensity. The devices were then coated with human thrombin binding aptamer. Several concentrations of thrombin in buffer solution were made, ranging from 1nM to 1µM. All the concentrations were detectable by the devices demonstrating that sub-nM concentrations may be monitored.
|Title of host publication||Biophotonics|
|Subtitle of host publication||photonic solutions for better health care II|
|Editors||Jürgen Popp, Wolfgangs Drexler, Valery V. Tuchin, Dennis L. Matthew|
|Number of pages||6|
|Publication status||Published - Apr 2010|
|Event||Biophotonics: Photonic Solutions for Better Health Care - Brussels, Belgium|
Duration: 12 Apr 2010 → 16 Apr 2010
|Conference||Biophotonics: Photonic Solutions for Better Health Care|
|Period||12/04/10 → 16/04/10|
Bibliographical noteProc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77151C (May 17, 2010)
Allsop, Thomas D.P.; Nagel, David; Neal, Ron; Davies, Edward M.; Mou, Chengbo; Bond, Peter; Rehman, Saeed; Kalli, Kyriacos; Webb, David J.; Calverhouse, Phil; Mascini, Marco; Bennion, Ian, "Aptamer-based surface plasmon sensor for thrombin detection", Biophotonics: photonic solutions for better health care II., ed. Jürgen Popp; Wolfgangs Drexler; Valery V. Tuchin; Dennis L. Matthew. Vol. 7715 SPIE, 2010. (SPIE proceedings).
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- fibre optic sensors
- surface plasmons