Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis?

Tracey E. Toms, Vasileios F. Panoulas, Karen M.J. Douglas, Peter Nightingale, Jacqueline P. Smith, Helen Griffiths, Naveed Sattar, Deborah P.M. Symmons, George D. Kitas

Research output: Contribution to journalArticle

Abstract

Rheumatoid arthritis (RA) associates with excess cardiovascular risk and there is a need to assess that risk. However, individual lipid levels may be influenced by disease activity and drug use, whereas lipid ratios may be more robust. A cross-sectional cohort of 400 consecutive patients was used to establish factors that influenced individual lipid levels and lipid ratios in RA, using multiple regression models. A further longitudinal cohort of 550 patients with RA was used to confirm these findings, using generalized estimating equations. Cross-sectionally, higher C-reactive protein (CRP) levels correlated with lower levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol ([HDL-C] P = .015), whereas lipid ratios did not correlate with CRP. The findings were broadly replicated in the longitudinal data. In summary, the effects of inflammation on individual lipid levels may underestimate lipid-associated cardiovascular disease (CVD) risk in RA, thus lipid ratios may be more appropriate for CVD risk stratification in RA.
LanguageEnglish
Pages167-175
Number of pages9
JournalAngiology
Volume62
Issue number2
Early online date3 Aug 2010
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Rheumatoid Arthritis
Inflammation
Lipids
C-Reactive Protein
Cardiovascular Diseases
LDL Cholesterol
HDL Cholesterol
Cholesterol
Pharmaceutical Preparations

Keywords

  • aged
  • anti-inflammatory agents
  • antirheumatic agents
  • rheumatoid arthritis
  • c-reactive protein
  • cohort studies
  • cross-sectional studies
  • dyslipidemias
  • female
  • humans
  • lipids
  • male
  • middle aged
  • retrospective studies
  • risk factors

Cite this

Toms, T. E., Panoulas, V. F., Douglas, K. M. J., Nightingale, P., Smith, J. P., Griffiths, H., ... Kitas, G. D. (2011). Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis? Angiology, 62(2), 167-175. https://doi.org/10.1177/0003319710373749
Toms, Tracey E. ; Panoulas, Vasileios F. ; Douglas, Karen M.J. ; Nightingale, Peter ; Smith, Jacqueline P. ; Griffiths, Helen ; Sattar, Naveed ; Symmons, Deborah P.M. ; Kitas, George D. / Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis?. In: Angiology. 2011 ; Vol. 62, No. 2. pp. 167-175.
@article{a9f7730a069043829cfc6479c33a5020,
title = "Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis?",
abstract = "Rheumatoid arthritis (RA) associates with excess cardiovascular risk and there is a need to assess that risk. However, individual lipid levels may be influenced by disease activity and drug use, whereas lipid ratios may be more robust. A cross-sectional cohort of 400 consecutive patients was used to establish factors that influenced individual lipid levels and lipid ratios in RA, using multiple regression models. A further longitudinal cohort of 550 patients with RA was used to confirm these findings, using generalized estimating equations. Cross-sectionally, higher C-reactive protein (CRP) levels correlated with lower levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol ([HDL-C] P = .015), whereas lipid ratios did not correlate with CRP. The findings were broadly replicated in the longitudinal data. In summary, the effects of inflammation on individual lipid levels may underestimate lipid-associated cardiovascular disease (CVD) risk in RA, thus lipid ratios may be more appropriate for CVD risk stratification in RA.",
keywords = "aged, anti-inflammatory agents, antirheumatic agents, rheumatoid arthritis, c-reactive protein, cohort studies, cross-sectional studies, dyslipidemias, female, humans, lipids, male, middle aged, retrospective studies, risk factors",
author = "Toms, {Tracey E.} and Panoulas, {Vasileios F.} and Douglas, {Karen M.J.} and Peter Nightingale and Smith, {Jacqueline P.} and Helen Griffiths and Naveed Sattar and Symmons, {Deborah P.M.} and Kitas, {George D.}",
year = "2011",
month = "2",
doi = "10.1177/0003319710373749",
language = "English",
volume = "62",
pages = "167--175",
journal = "Angiology",
issn = "0003-3197",
publisher = "SAGE",
number = "2",

}

Toms, TE, Panoulas, VF, Douglas, KMJ, Nightingale, P, Smith, JP, Griffiths, H, Sattar, N, Symmons, DPM & Kitas, GD 2011, 'Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis?' Angiology, vol. 62, no. 2, pp. 167-175. https://doi.org/10.1177/0003319710373749

Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis? / Toms, Tracey E.; Panoulas, Vasileios F.; Douglas, Karen M.J.; Nightingale, Peter; Smith, Jacqueline P.; Griffiths, Helen; Sattar, Naveed; Symmons, Deborah P.M.; Kitas, George D.

In: Angiology, Vol. 62, No. 2, 02.2011, p. 167-175.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis?

AU - Toms, Tracey E.

AU - Panoulas, Vasileios F.

AU - Douglas, Karen M.J.

AU - Nightingale, Peter

AU - Smith, Jacqueline P.

AU - Griffiths, Helen

AU - Sattar, Naveed

AU - Symmons, Deborah P.M.

AU - Kitas, George D.

PY - 2011/2

Y1 - 2011/2

N2 - Rheumatoid arthritis (RA) associates with excess cardiovascular risk and there is a need to assess that risk. However, individual lipid levels may be influenced by disease activity and drug use, whereas lipid ratios may be more robust. A cross-sectional cohort of 400 consecutive patients was used to establish factors that influenced individual lipid levels and lipid ratios in RA, using multiple regression models. A further longitudinal cohort of 550 patients with RA was used to confirm these findings, using generalized estimating equations. Cross-sectionally, higher C-reactive protein (CRP) levels correlated with lower levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol ([HDL-C] P = .015), whereas lipid ratios did not correlate with CRP. The findings were broadly replicated in the longitudinal data. In summary, the effects of inflammation on individual lipid levels may underestimate lipid-associated cardiovascular disease (CVD) risk in RA, thus lipid ratios may be more appropriate for CVD risk stratification in RA.

AB - Rheumatoid arthritis (RA) associates with excess cardiovascular risk and there is a need to assess that risk. However, individual lipid levels may be influenced by disease activity and drug use, whereas lipid ratios may be more robust. A cross-sectional cohort of 400 consecutive patients was used to establish factors that influenced individual lipid levels and lipid ratios in RA, using multiple regression models. A further longitudinal cohort of 550 patients with RA was used to confirm these findings, using generalized estimating equations. Cross-sectionally, higher C-reactive protein (CRP) levels correlated with lower levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol ([HDL-C] P = .015), whereas lipid ratios did not correlate with CRP. The findings were broadly replicated in the longitudinal data. In summary, the effects of inflammation on individual lipid levels may underestimate lipid-associated cardiovascular disease (CVD) risk in RA, thus lipid ratios may be more appropriate for CVD risk stratification in RA.

KW - aged

KW - anti-inflammatory agents

KW - antirheumatic agents

KW - rheumatoid arthritis

KW - c-reactive protein

KW - cohort studies

KW - cross-sectional studies

KW - dyslipidemias

KW - female

KW - humans

KW - lipids

KW - male

KW - middle aged

KW - retrospective studies

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=78651401373&partnerID=8YFLogxK

UR - http://ang.sagepub.com/content/62/2/167

U2 - 10.1177/0003319710373749

DO - 10.1177/0003319710373749

M3 - Article

VL - 62

SP - 167

EP - 175

JO - Angiology

T2 - Angiology

JF - Angiology

SN - 0003-3197

IS - 2

ER -