Assisted reproductive therapies and imprinting disorders--a preliminary British survey

A G Sutcliffe; C J Peters; S Bowdin; K Temple; W Reardon; L Wilson; J Clayton-Smith; L A Brueton; W Bannister; E R Maher

doi:10.1093/humrep/dei405

Assisted reproductive therapies and imprinting disorders--a preliminary British survey

A G Sutcliffe
, C J Peters
, S Bowdin
, K Temple
, W Reardon
, L Wilson
, J Clayton-Smith
, L A Brueton
, W Bannister
, E R Maher

Aston Medical School

Research output: Contribution to journal › Article › peer-review

223 Citations (Scopus)

Abstract

BACKGROUND: Recent reports have suggested a higher risk of Beckwith-Wiedemann syndrome (BWS) and Angelman syndrome (AS) after assisted reproductive technologies (ARTs), but it is unclear whether this might also apply to other disorders of genomic imprinting.

METHODS: We contacted families of children with BWS, AS, Prader-Willi syndrome (PWS) and transient neonatal diabetes mellitus (TNDM) to determine use of ART.

RESULTS: A statistically significant increased frequency of ART in children with BWS was confirmed [2.9%, 95% confidence interval (CI) 1.4-6.3% vs 0.8% expected] but there was no significant association with PWS or TNDM. Consideration of the molecular subgroup of BWS and AS suggested the feasibility of association with ART.

CONCLUSIONS: These differences may relate to variations in (i) the molecular mechanisms for disordered imprinting in the different disorders and (ii) the susceptibility of specific imprinting control regions to ART-associated methylation alterations (epimutations).

Original language	English
Pages (from-to)	1009-1011
Number of pages	3
Journal	Human Reproduction
Volume	21
Issue number	4
DOIs	https://doi.org/10.1093/humrep/dei405
Publication status	Published - Apr 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Angelman Syndrome/epidemiology
Beckwith-Wiedemann Syndrome/epidemiology
Chromosome Disorders/epidemiology
Genomic Imprinting
Humans
Reproductive Techniques, Assisted/adverse effects
Risk Factors
United Kingdom/epidemiology

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10.1093/humrep/dei405

Cite this

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title = "Assisted reproductive therapies and imprinting disorders--a preliminary British survey",

abstract = "BACKGROUND: Recent reports have suggested a higher risk of Beckwith-Wiedemann syndrome (BWS) and Angelman syndrome (AS) after assisted reproductive technologies (ARTs), but it is unclear whether this might also apply to other disorders of genomic imprinting.METHODS: We contacted families of children with BWS, AS, Prader-Willi syndrome (PWS) and transient neonatal diabetes mellitus (TNDM) to determine use of ART.RESULTS: A statistically significant increased frequency of ART in children with BWS was confirmed [2.9\%, 95\% confidence interval (CI) 1.4-6.3\% vs 0.8\% expected] but there was no significant association with PWS or TNDM. Consideration of the molecular subgroup of BWS and AS suggested the feasibility of association with ART.CONCLUSIONS: These differences may relate to variations in (i) the molecular mechanisms for disordered imprinting in the different disorders and (ii) the susceptibility of specific imprinting control regions to ART-associated methylation alterations (epimutations).",

keywords = "Angelman Syndrome/epidemiology, Beckwith-Wiedemann Syndrome/epidemiology, Chromosome Disorders/epidemiology, Genomic Imprinting, Humans, Reproductive Techniques, Assisted/adverse effects, Risk Factors, United Kingdom/epidemiology",

author = "Sutcliffe, \{A G\} and Peters, \{C J\} and S Bowdin and K Temple and W Reardon and L Wilson and J Clayton-Smith and Brueton, \{L A\} and W Bannister and Maher, \{E R\}",

year = "2006",

month = apr,

doi = "10.1093/humrep/dei405",

language = "English",

volume = "21",

pages = "1009--1011",

journal = "Human Reproduction",

issn = "0268-1161",

publisher = "Oxford University Press",

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T1 - Assisted reproductive therapies and imprinting disorders--a preliminary British survey

AU - Sutcliffe, A G

AU - Peters, C J

AU - Bowdin, S

AU - Temple, K

AU - Reardon, W

AU - Wilson, L

AU - Clayton-Smith, J

AU - Brueton, L A

AU - Bannister, W

AU - Maher, E R

PY - 2006/4

Y1 - 2006/4

N2 - BACKGROUND: Recent reports have suggested a higher risk of Beckwith-Wiedemann syndrome (BWS) and Angelman syndrome (AS) after assisted reproductive technologies (ARTs), but it is unclear whether this might also apply to other disorders of genomic imprinting.METHODS: We contacted families of children with BWS, AS, Prader-Willi syndrome (PWS) and transient neonatal diabetes mellitus (TNDM) to determine use of ART.RESULTS: A statistically significant increased frequency of ART in children with BWS was confirmed [2.9%, 95% confidence interval (CI) 1.4-6.3% vs 0.8% expected] but there was no significant association with PWS or TNDM. Consideration of the molecular subgroup of BWS and AS suggested the feasibility of association with ART.CONCLUSIONS: These differences may relate to variations in (i) the molecular mechanisms for disordered imprinting in the different disorders and (ii) the susceptibility of specific imprinting control regions to ART-associated methylation alterations (epimutations).

AB - BACKGROUND: Recent reports have suggested a higher risk of Beckwith-Wiedemann syndrome (BWS) and Angelman syndrome (AS) after assisted reproductive technologies (ARTs), but it is unclear whether this might also apply to other disorders of genomic imprinting.METHODS: We contacted families of children with BWS, AS, Prader-Willi syndrome (PWS) and transient neonatal diabetes mellitus (TNDM) to determine use of ART.RESULTS: A statistically significant increased frequency of ART in children with BWS was confirmed [2.9%, 95% confidence interval (CI) 1.4-6.3% vs 0.8% expected] but there was no significant association with PWS or TNDM. Consideration of the molecular subgroup of BWS and AS suggested the feasibility of association with ART.CONCLUSIONS: These differences may relate to variations in (i) the molecular mechanisms for disordered imprinting in the different disorders and (ii) the susceptibility of specific imprinting control regions to ART-associated methylation alterations (epimutations).

KW - Angelman Syndrome/epidemiology

KW - Beckwith-Wiedemann Syndrome/epidemiology

KW - Chromosome Disorders/epidemiology

KW - Genomic Imprinting

KW - Humans

KW - Reproductive Techniques, Assisted/adverse effects

KW - Risk Factors

KW - United Kingdom/epidemiology

UR - https://academic.oup.com/humrep/article/21/4/1009/585475

U2 - 10.1093/humrep/dei405

DO - 10.1093/humrep/dei405

M3 - Article

C2 - 16361294

SN - 0268-1161

VL - 21

SP - 1009

EP - 1011

JO - Human Reproduction

JF - Human Reproduction

IS - 4

ER -

Assisted reproductive therapies and imprinting disorders--a preliminary British survey

Abstract

UN SDGs

Keywords

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