Association behavior of the synthetic protein-lipid complex analogues

P. Punyamoonwongsa*, B.J. Tighe

*Corresponding author for this work

Research output: Chapter in Book/Published conference outputConference publication


Hypercoiling poly(styrene-ALT-maleic anhydride) (PSMA) is known to undergo conformational transition in response to environmental stimuli. This behavior allows it to associate with the phospholipid, 2-dilauryl-SN-glycero-3- phosphocholine (DLPC) to produce nanostructures analogous to lipoproteins. The complex represents a new bio-mimetic delivery vehicle with applications in the cosmetic and pharmaceutical industries. This study investigates, for the first time, the association behavior of PSMA and DLPC through the combination of different analytical techniques. The results indicate that the association is primarily driven by hydrophobic interactions and depends on various factors including the polymer/lipid ratio, the polymer molecular weight and the pH of the aqueous environment. The conformational transition of PSMA leads to the formation of discrete micellar complexes involving anisotropic-to-isotropic lipid phase transformation. As the number of hydrophobic moieties in the polymer is increased, the pH-dependent conformational transition of the polymer plays less important part in achieving this phase transition of the lipid.

Original languageEnglish
Title of host publicationBiomaterials and applications
EditorsTawee Tunkasiri
Number of pages4
ISBN (Print)978-3-037-85406-8
Publication statusPublished - Apr 2012
EventChiang Mai International Conference on Biomaterials and Applications 2011 - Chiang Mai, Thailand
Duration: 9 Aug 201110 Aug 2011

Publication series

NameAdvanced Materials Research
ISSN (Print)1022-6680


ConferenceChiang Mai International Conference on Biomaterials and Applications 2011
Abbreviated titleCMICBA 2011
CityChiang Mai


  • biomimetic
  • drug delivery
  • responsive polymers


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