Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study

Eric Yuk Fai Wan; Anna Hoi Ying Mok; Vincent Ka Chun Yan; Cheyenne I. Ying Chan; Boyuan Wang; Francisco Tsz Tsun Lai; Celine Sze Ling Chui; Xue Li; Carlos King Ho Wong; Kai Hang Yiu; Hung Fat Tse; Chak Sing Lau; Ian Chi Kei Wong; Esther Wai Yin Chan

doi:10.1016/j.xcrm.2023.101195

Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study

Eric Yuk Fai Wan, Anna Hoi Ying Mok, Vincent Ka Chun Yan, Cheyenne I. Ying Chan, Boyuan Wang, Francisco Tsz Tsun Lai, Celine Sze Ling Chui, Xue Li, Carlos King Ho Wong, Kai Hang Yiu, Hung Fat Tse, Chak Sing Lau, Ian Chi Kei Wong, Esther Wai Yin Chan

Aston Pharmacy School

Research output: Contribution to journal › Article › peer-review

Abstract

It is unknown if vaccination affects the risk of post-COVID-19 cardiovascular diseases (CVDs). Therefore, this retrospective cohort study examines the short-term and long-term risks of post-infection CVD among COVID-19 patients with different vaccination status utilizing data from electronic health databases in Hong Kong. Cox proportional hazards regression adjusted with inverse probability of treatment weighting is used to evaluate the risks of incident CVD (coronary heart disease, stroke, heart failure) and all-cause mortality in COVID-19 patients. Compared with unvaccinated patients, vaccinated patients have a lower risk of CVD and all-cause mortality, and the lowest risk is observed in those who completed three doses of vaccine. Similar patterns in the subgroups of different vaccine platforms, age, gender, Charlson comorbidity index, and disease severity are observed. These findings highlight a positive dose-response relationship between overall CVD risk reduction and the number of vaccine doses received.

Original language	English
Article number	101195
Number of pages	12
Journal	Cell Reports Medicine
Volume	4
Issue number	10
Early online date	15 Sept 2023
DOIs	https://doi.org/10.1016/j.xcrm.2023.101195
Publication status	Published - 17 Oct 2023

Bibliographical note

Data Access Statement

The original code for the main analysis has been deposited on github (https://github.com/kcyan96/hope_vaccine_cvd) and is publicly available as of the date of publication. Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.

The electronic health records, vaccination records and COVID-19 infection records datasets cannot be deposited in a public repository because these are confidential medical records and the data custodians (the Hospital Authority and the Department of Health of the Hong Kong Special Administrative Region) have not given permission for sharing due to patient confidentiality and privacy concerns. For access, please approach the lead contact to direct your request to the Hospital Authority’s data sharing portal. In addition, processed datasets derived from these data which were used in the analyses reported in this paper will be shared by the lead contact upon request. Any additional information required to reanalyze the data reported in this work paper is available from the lead contact upon request.

Keywords

Humans
Cardiovascular Diseases/epidemiology
BNT162 Vaccine
Cohort Studies
Retrospective Studies
COVID-19/epidemiology
Vaccination

Access to Document

10.1016/j.xcrm.2023.101195Licence: CC BY-NC-ND 4.0

EYF Wan et al_Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection
Copyright © 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Final published version, 3.29 MBLicence: CC BY-NC-ND 4.0

Cite this

Wan, E. Y. F., Mok, A. H. Y., Yan, V. K. C., Chan, C. I. Y., Wang, B., Lai, F. T. T., Chui, C. S. L., Li, X., Wong, C. K. H., Yiu, K. H., Tse, H. F., Lau, C. S., Wong, I. C. K., & Chan, E. W. Y. (2023). Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study. Cell Reports Medicine, 4(10), Article 101195. https://doi.org/10.1016/j.xcrm.2023.101195

@article{76c546fe851842beb9190fa952e6170a,

title = "Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study",

abstract = "It is unknown if vaccination affects the risk of post-COVID-19 cardiovascular diseases (CVDs). Therefore, this retrospective cohort study examines the short-term and long-term risks of post-infection CVD among COVID-19 patients with different vaccination status utilizing data from electronic health databases in Hong Kong. Cox proportional hazards regression adjusted with inverse probability of treatment weighting is used to evaluate the risks of incident CVD (coronary heart disease, stroke, heart failure) and all-cause mortality in COVID-19 patients. Compared with unvaccinated patients, vaccinated patients have a lower risk of CVD and all-cause mortality, and the lowest risk is observed in those who completed three doses of vaccine. Similar patterns in the subgroups of different vaccine platforms, age, gender, Charlson comorbidity index, and disease severity are observed. These findings highlight a positive dose-response relationship between overall CVD risk reduction and the number of vaccine doses received.",

keywords = "Humans, Cardiovascular Diseases/epidemiology, BNT162 Vaccine, Cohort Studies, Retrospective Studies, COVID-19/epidemiology, Vaccination",

author = "Wan, {Eric Yuk Fai} and Mok, {Anna Hoi Ying} and Yan, {Vincent Ka Chun} and Chan, {Cheyenne I. Ying} and Boyuan Wang and Lai, {Francisco Tsz Tsun} and Chui, {Celine Sze Ling} and Xue Li and Wong, {Carlos King Ho} and Yiu, {Kai Hang} and Tse, {Hung Fat} and Lau, {Chak Sing} and Wong, {Ian Chi Kei} and Chan, {Esther Wai Yin}",

note = "Copyright {\textcopyright} 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/). ",

year = "2023",

month = oct,

day = "17",

doi = "10.1016/j.xcrm.2023.101195",

language = "English",

volume = "4",

number = "10",

}

Wan, EYF, Mok, AHY, Yan, VKC, Chan, CIY, Wang, B, Lai, FTT, Chui, CSL, Li, X, Wong, CKH, Yiu, KH, Tse, HF, Lau, CS, Wong, ICK & Chan, EWY 2023, 'Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study', Cell Reports Medicine, vol. 4, no. 10, 101195. https://doi.org/10.1016/j.xcrm.2023.101195

TY - JOUR

T1 - Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study

AU - Wan, Eric Yuk Fai

AU - Mok, Anna Hoi Ying

AU - Yan, Vincent Ka Chun

AU - Chan, Cheyenne I. Ying

AU - Wang, Boyuan

AU - Lai, Francisco Tsz Tsun

AU - Chui, Celine Sze Ling

AU - Li, Xue

AU - Wong, Carlos King Ho

AU - Yiu, Kai Hang

AU - Tse, Hung Fat

AU - Lau, Chak Sing

AU - Wong, Ian Chi Kei

AU - Chan, Esther Wai Yin

PY - 2023/10/17

Y1 - 2023/10/17

N2 - It is unknown if vaccination affects the risk of post-COVID-19 cardiovascular diseases (CVDs). Therefore, this retrospective cohort study examines the short-term and long-term risks of post-infection CVD among COVID-19 patients with different vaccination status utilizing data from electronic health databases in Hong Kong. Cox proportional hazards regression adjusted with inverse probability of treatment weighting is used to evaluate the risks of incident CVD (coronary heart disease, stroke, heart failure) and all-cause mortality in COVID-19 patients. Compared with unvaccinated patients, vaccinated patients have a lower risk of CVD and all-cause mortality, and the lowest risk is observed in those who completed three doses of vaccine. Similar patterns in the subgroups of different vaccine platforms, age, gender, Charlson comorbidity index, and disease severity are observed. These findings highlight a positive dose-response relationship between overall CVD risk reduction and the number of vaccine doses received.

AB - It is unknown if vaccination affects the risk of post-COVID-19 cardiovascular diseases (CVDs). Therefore, this retrospective cohort study examines the short-term and long-term risks of post-infection CVD among COVID-19 patients with different vaccination status utilizing data from electronic health databases in Hong Kong. Cox proportional hazards regression adjusted with inverse probability of treatment weighting is used to evaluate the risks of incident CVD (coronary heart disease, stroke, heart failure) and all-cause mortality in COVID-19 patients. Compared with unvaccinated patients, vaccinated patients have a lower risk of CVD and all-cause mortality, and the lowest risk is observed in those who completed three doses of vaccine. Similar patterns in the subgroups of different vaccine platforms, age, gender, Charlson comorbidity index, and disease severity are observed. These findings highlight a positive dose-response relationship between overall CVD risk reduction and the number of vaccine doses received.

KW - Humans

KW - Cardiovascular Diseases/epidemiology

KW - BNT162 Vaccine

KW - Cohort Studies

KW - Retrospective Studies

KW - COVID-19/epidemiology

KW - Vaccination

UR - https://www.sciencedirect.com/science/article/pii/S2666379123003622

U2 - 10.1016/j.xcrm.2023.101195

DO - 10.1016/j.xcrm.2023.101195

M3 - Article

C2 - 37716352

SN - 2666-3791

VL - 4

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 10

M1 - 101195

ER -

Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study

Abstract

Bibliographical note

Data Access Statement

Keywords

Access to Document

Other files and links

Fingerprint

Cite this