Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study

Eric Yuk Fai Wan; Anna Hoi Ying Mok; Vincent Ka Chun Yan; Cheyenne I. Ying Chan; Boyuan Wang; Francisco Tsz Tsun Lai; Celine Sze Ling Chui; Xue Li; Carlos King Ho Wong; Kai Hang Yiu; Hung Fat Tse; Chak Sing Lau; Ian Chi Kei Wong; Esther Wai Yin Chan

doi:10.1016/j.xcrm.2023.101195

Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study

Eric Yuk Fai Wan
, Anna Hoi Ying Mok
, Vincent Ka Chun Yan
, Cheyenne I. Ying Chan
, Boyuan Wang
, Francisco Tsz Tsun Lai
, Celine Sze Ling Chui
, Xue Li
, Carlos King Ho Wong
, Kai Hang Yiu
, Hung Fat Tse
, Chak Sing Lau
, Ian Chi Kei Wong
, Esther Wai Yin Chan

Aston Pharmacy School

Education University of Hong Kong

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

11 Downloads (Pure)

Abstract

It is unknown if vaccination affects the risk of post-COVID-19 cardiovascular diseases (CVDs). Therefore, this retrospective cohort study examines the short-term and long-term risks of post-infection CVD among COVID-19 patients with different vaccination status utilizing data from electronic health databases in Hong Kong. Cox proportional hazards regression adjusted with inverse probability of treatment weighting is used to evaluate the risks of incident CVD (coronary heart disease, stroke, heart failure) and all-cause mortality in COVID-19 patients. Compared with unvaccinated patients, vaccinated patients have a lower risk of CVD and all-cause mortality, and the lowest risk is observed in those who completed three doses of vaccine. Similar patterns in the subgroups of different vaccine platforms, age, gender, Charlson comorbidity index, and disease severity are observed. These findings highlight a positive dose-response relationship between overall CVD risk reduction and the number of vaccine doses received.

Original language	English
Article number	101195
Number of pages	12
Journal	Cell Reports Medicine
Volume	4
Issue number	10
Early online date	15 Sept 2023
DOIs	https://doi.org/10.1016/j.xcrm.2023.101195
Publication status	Published - 17 Oct 2023

Bibliographical note

Data Access Statement

The original code for the main analysis has been deposited on github (https://github.com/kcyan96/hope_vaccine_cvd) and is publicly available as of the date of publication. Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.

The electronic health records, vaccination records and COVID-19 infection records datasets cannot be deposited in a public repository because these are confidential medical records and the data custodians (the Hospital Authority and the Department of Health of the Hong Kong Special Administrative Region) have not given permission for sharing due to patient confidentiality and privacy concerns. For access, please approach the lead contact to direct your request to the Hospital Authority’s data sharing portal. In addition, processed datasets derived from these data which were used in the analyses reported in this paper will be shared by the lead contact upon request. Any additional information required to reanalyze the data reported in this work paper is available from the lead contact upon request.

Funding

This work was supported by funding from HMRF Research on COVID-19, The Hong Kong Special Administrative Region (HKSAR) Government (principal investigator, E.W.C.; ref. no. COVID1903011); Collaborative Research Fund, University Grants Committee, the HKSAR Government (principal investigator, I.C.K.W.; ref. no. C7154-20GF); and a research grant from the Health Bureau, the HKSAR Government (principal investigator, I.C.K.W.; ref. no. COVID19F01). I.C.K.W. and F.T.T.L. are partially supported by the Laboratory of Data Discovery for Health (D24H) funded by the AIR@InnoHK administered by Innovation and Technology Commission.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Humans
Cardiovascular Diseases/epidemiology
BNT162 Vaccine
Cohort Studies
Retrospective Studies
COVID-19/epidemiology
Vaccination

Access to Document

10.1016/j.xcrm.2023.101195Licence: CC BY-NC-ND 4.0

EYF Wan et al_Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection
Copyright © 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Final published version, 3.29 MBLicence: CC BY-NC-ND 4.0

Cite this

Wan, E. Y. F., Mok, A. H. Y., Yan, V. K. C., Chan, C. I. Y., Wang, B., Lai, F. T. T., Chui, C. S. L., Li, X., Wong, C. K. H., Yiu, K. H., Tse, H. F., Lau, C. S., Wong, I. C. K., & Chan, E. W. Y. (2023). Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study. Cell Reports Medicine, 4(10), Article 101195. https://doi.org/10.1016/j.xcrm.2023.101195

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abstract = "It is unknown if vaccination affects the risk of post-COVID-19 cardiovascular diseases (CVDs). Therefore, this retrospective cohort study examines the short-term and long-term risks of post-infection CVD among COVID-19 patients with different vaccination status utilizing data from electronic health databases in Hong Kong. Cox proportional hazards regression adjusted with inverse probability of treatment weighting is used to evaluate the risks of incident CVD (coronary heart disease, stroke, heart failure) and all-cause mortality in COVID-19 patients. Compared with unvaccinated patients, vaccinated patients have a lower risk of CVD and all-cause mortality, and the lowest risk is observed in those who completed three doses of vaccine. Similar patterns in the subgroups of different vaccine platforms, age, gender, Charlson comorbidity index, and disease severity are observed. These findings highlight a positive dose-response relationship between overall CVD risk reduction and the number of vaccine doses received.",

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Wan, EYF, Mok, AHY, Yan, VKC, Chan, CIY, Wang, B, Lai, FTT, Chui, CSL, Li, X, Wong, CKH, Yiu, KH, Tse, HF, Lau, CS, Wong, ICK & Chan, EWY 2023, 'Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study', Cell Reports Medicine, vol. 4, no. 10, 101195. https://doi.org/10.1016/j.xcrm.2023.101195

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AU - Chan, Cheyenne I. Ying

AU - Wang, Boyuan

AU - Lai, Francisco Tsz Tsun

AU - Chui, Celine Sze Ling

AU - Li, Xue

AU - Wong, Carlos King Ho

AU - Yiu, Kai Hang

AU - Tse, Hung Fat

AU - Lau, Chak Sing

AU - Wong, Ian Chi Kei

AU - Chan, Esther Wai Yin

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N2 - It is unknown if vaccination affects the risk of post-COVID-19 cardiovascular diseases (CVDs). Therefore, this retrospective cohort study examines the short-term and long-term risks of post-infection CVD among COVID-19 patients with different vaccination status utilizing data from electronic health databases in Hong Kong. Cox proportional hazards regression adjusted with inverse probability of treatment weighting is used to evaluate the risks of incident CVD (coronary heart disease, stroke, heart failure) and all-cause mortality in COVID-19 patients. Compared with unvaccinated patients, vaccinated patients have a lower risk of CVD and all-cause mortality, and the lowest risk is observed in those who completed three doses of vaccine. Similar patterns in the subgroups of different vaccine platforms, age, gender, Charlson comorbidity index, and disease severity are observed. These findings highlight a positive dose-response relationship between overall CVD risk reduction and the number of vaccine doses received.

AB - It is unknown if vaccination affects the risk of post-COVID-19 cardiovascular diseases (CVDs). Therefore, this retrospective cohort study examines the short-term and long-term risks of post-infection CVD among COVID-19 patients with different vaccination status utilizing data from electronic health databases in Hong Kong. Cox proportional hazards regression adjusted with inverse probability of treatment weighting is used to evaluate the risks of incident CVD (coronary heart disease, stroke, heart failure) and all-cause mortality in COVID-19 patients. Compared with unvaccinated patients, vaccinated patients have a lower risk of CVD and all-cause mortality, and the lowest risk is observed in those who completed three doses of vaccine. Similar patterns in the subgroups of different vaccine platforms, age, gender, Charlson comorbidity index, and disease severity are observed. These findings highlight a positive dose-response relationship between overall CVD risk reduction and the number of vaccine doses received.

KW - Humans

KW - Cardiovascular Diseases/epidemiology

KW - BNT162 Vaccine

KW - Cohort Studies

KW - Retrospective Studies

KW - COVID-19/epidemiology

KW - Vaccination

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SN - 2666-3791

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JO - Cell Reports Medicine

JF - Cell Reports Medicine

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ER -

Association between BNT162b2 and CoronaVac vaccination and risk of CVD and mortality after COVID-19 infection: A population-based cohort study

Abstract

Bibliographical note

Data Access Statement

Funding

UN SDGs

Keywords

Access to Document

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Cite this