Association between gout and atrial fibrillation: A meta-analysis of observational studies

Keith Sai Kit Leung; Mengqi Gong; Yingzhi Liu; Rachel Wing Chuen Lai; Chengsheng Ju; Fangzhou Liu; Michael Huen Sum Lam; Leonardo Roever; Dong Chang; Yunlong Xia; Tong Liu; Gary Tse; Ka Hou Christien Li

doi:10.12688/f1000research.17104.1

Association between gout and atrial fibrillation: A meta-analysis of observational studies

Keith Sai Kit Leung
, Mengqi Gong
, Yingzhi Liu
, Rachel Wing Chuen Lai
, Chengsheng Ju
, Fangzhou Liu
, Michael Huen Sum Lam
, Leonardo Roever
, Dong Chang
, Yunlong Xia
, Tong Liu
, Gary Tse
, Ka Hou Christien Li

Aston Medical School

Research output: Contribution to journal › Article › peer-review

1 Citation (SciVal)

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Abstract

Background: Gout is a systemic inflammatory arthritis characterized by the deposition of monosodium urate crystals due to hyperuricemia. Previous studies have explored the link between gout and atrial fibrillation (AF). Given the increasing prevalence and incidence of gout, there is a need to quantify the relationship between gout and the risk of AF. Therefore, we conducted a systematic review and meta-analysis on this topic.
Methods: PubMed and Embase were searched for studies that reported the association between gout and AF using the following search term: (‘Gout’ and ‘Arrhythmia’). The search period was from the start of the database to 3rd August 2018 with no language restrictions.
Results: A total of 75 and 22 articles were retrieved from PubMed and Embase, respectively. Of these, four observational studies (three cohort studies, one case-control study) including 659,094 patients were included. Our meta-analysis demonstrated that gout was significantly associated with increased risk of AF (adjusted hazard ratio: 1.31; 95% confidence interval: 1.00-1.70; P = 0.05; I2 = 99%) after adjusting for significant comorbidities and confounders.
Conclusions: Our meta-analysis confirms the significant relationship between gout and AF. More data are needed to determine whether this risk can be adequately reduced by urate-lowering therapy.

Original language	English
Article number	1924
Journal	F1000Research
Volume	7
DOIs	https://doi.org/10.12688/f1000research.17104.1
Publication status	Published - 11 Dec 2018

Bibliographical note

Copyright: © 2018 Leung KSK et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Association between gout and atrial fibrillation: A meta-analysis of observational studies
Copyright: © 2018 Leung KSK et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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title = "Association between gout and atrial fibrillation: A meta-analysis of observational studies",

abstract = "Background: Gout is a systemic inflammatory arthritis characterized by the deposition of monosodium urate crystals due to hyperuricemia. Previous studies have explored the link between gout and atrial fibrillation (AF). Given the increasing prevalence and incidence of gout, there is a need to quantify the relationship between gout and the risk of AF. Therefore, we conducted a systematic review and meta-analysis on this topic. Methods: PubMed and Embase were searched for studies that reported the association between gout and AF using the following search term: ({\textquoteleft}Gout{\textquoteright} and {\textquoteleft}Arrhythmia{\textquoteright}). The search period was from the start of the database to 3rd August 2018 with no language restrictions. Results: A total of 75 and 22 articles were retrieved from PubMed and Embase, respectively. Of these, four observational studies (three cohort studies, one case-control study) including 659,094 patients were included. Our meta-analysis demonstrated that gout was significantly associated with increased risk of AF (adjusted hazard ratio: 1.31; 95\% confidence interval: 1.00-1.70; P = 0.05; I2 = 99\%) after adjusting for significant comorbidities and confounders. Conclusions: Our meta-analysis confirms the significant relationship between gout and AF. More data are needed to determine whether this risk can be adequately reduced by urate-lowering therapy.",

author = "Leung, \{Keith Sai Kit\} and Mengqi Gong and Yingzhi Liu and Lai, \{Rachel Wing Chuen\} and Chengsheng Ju and Fangzhou Liu and Lam, \{Michael Huen Sum\} and Leonardo Roever and Dong Chang and Yunlong Xia and Tong Liu and Gary Tse and Li, \{Ka Hou Christien\}",

note = "Copyright: {\textcopyright} 2018 Leung KSK et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",

year = "2018",

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AU - Gong, Mengqi

AU - Liu, Yingzhi

AU - Lai, Rachel Wing Chuen

AU - Ju, Chengsheng

AU - Liu, Fangzhou

AU - Lam, Michael Huen Sum

AU - Roever, Leonardo

AU - Chang, Dong

AU - Xia, Yunlong

AU - Liu, Tong

AU - Tse, Gary

AU - Li, Ka Hou Christien

N1 - Copyright: © 2018 Leung KSK et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2018/12/11

Y1 - 2018/12/11

N2 - Background: Gout is a systemic inflammatory arthritis characterized by the deposition of monosodium urate crystals due to hyperuricemia. Previous studies have explored the link between gout and atrial fibrillation (AF). Given the increasing prevalence and incidence of gout, there is a need to quantify the relationship between gout and the risk of AF. Therefore, we conducted a systematic review and meta-analysis on this topic. Methods: PubMed and Embase were searched for studies that reported the association between gout and AF using the following search term: (‘Gout’ and ‘Arrhythmia’). The search period was from the start of the database to 3rd August 2018 with no language restrictions. Results: A total of 75 and 22 articles were retrieved from PubMed and Embase, respectively. Of these, four observational studies (three cohort studies, one case-control study) including 659,094 patients were included. Our meta-analysis demonstrated that gout was significantly associated with increased risk of AF (adjusted hazard ratio: 1.31; 95% confidence interval: 1.00-1.70; P = 0.05; I2 = 99%) after adjusting for significant comorbidities and confounders. Conclusions: Our meta-analysis confirms the significant relationship between gout and AF. More data are needed to determine whether this risk can be adequately reduced by urate-lowering therapy.

AB - Background: Gout is a systemic inflammatory arthritis characterized by the deposition of monosodium urate crystals due to hyperuricemia. Previous studies have explored the link between gout and atrial fibrillation (AF). Given the increasing prevalence and incidence of gout, there is a need to quantify the relationship between gout and the risk of AF. Therefore, we conducted a systematic review and meta-analysis on this topic. Methods: PubMed and Embase were searched for studies that reported the association between gout and AF using the following search term: (‘Gout’ and ‘Arrhythmia’). The search period was from the start of the database to 3rd August 2018 with no language restrictions. Results: A total of 75 and 22 articles were retrieved from PubMed and Embase, respectively. Of these, four observational studies (three cohort studies, one case-control study) including 659,094 patients were included. Our meta-analysis demonstrated that gout was significantly associated with increased risk of AF (adjusted hazard ratio: 1.31; 95% confidence interval: 1.00-1.70; P = 0.05; I2 = 99%) after adjusting for significant comorbidities and confounders. Conclusions: Our meta-analysis confirms the significant relationship between gout and AF. More data are needed to determine whether this risk can be adequately reduced by urate-lowering therapy.

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Association between gout and atrial fibrillation: A meta-analysis of observational studies

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