Association of vitamin D-binding protein polymorphisms and serum 25(OH)D concentration varies among Chinese healthy infants of different VDR-FokI genotypes: A multi-centre cross-sectional study

Hing Wai Tsang; Keith T. S. Tung; Rosa S. Wong; Siew Yan Wong; Joanna Y. L. Tung; Gilbert T. Chua; Marco H. K. Ho; Chi Pui Pang; Wilfred H. S. Wong; Godfrey C. F. Chan; Ian C. K. Wong; Patrick Ip

doi:10.1111/nbu.12656

Association of vitamin D-binding protein polymorphisms and serum 25(OH)D concentration varies among Chinese healthy infants of different VDR-FokI genotypes: A multi-centre cross-sectional study

Hing Wai Tsang, Keith T. S. Tung, Rosa S. Wong, Siew Yan Wong, Joanna Y. L. Tung, Gilbert T. Chua, Marco H. K. Ho, Chi Pui Pang, Wilfred H. S. Wong, Godfrey C. F. Chan, Ian C. K. Wong, Patrick Ip^*

^*Corresponding author for this work

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Abstract

Hypovitaminosis D during infancy is associated with the development of chronic diseases and poor health later in life. While the effect of environmental factors on vitamin D concentration has been extensively explored, this study aimed to explore the effect of genetic factors on vitamin D concentration among Chinese infants. We conducted a multi-centre cross-sectional study in Hong Kong from July 2019 to May 2021. A candidate genetic approach was adopted to study four selected genetic variants of the vitamin D-binding protein (DBP) and vitamin D receptor (VDR) (rs4588, rs7041, rs2282679 and rs2228570) to examine their associations with measured serum 25(OH)D concentration. A total of 378 Chinese infants aged 2–12 months were recruited in this study. Peripheral blood samples were collected from the infants to measure serum 25(OH)D concentration and extract DNA. Results showed that rs7041T and rs2282679C were significantly associated with lower serum 25(OH)D concentration. Further analysis of the DBP variants revealed that the GC1F allele was significantly associated with lower 25(OH)D concentration and identified as the risk DBP isoform in infants. While our results revealed that there is no direct association between VDR-FokI genotype and serum 25(OH)D concentration, a VDR-FokI genotype-specific pattern was observed in the association between DBP isoforms and serum 25(OH)D concentration. Specifically, significant associations were observed in the DBP genotypes GC1F/F, GC1F/2 and GC1S/2 among VDR-FokI TT/TC carriers, but not in VDR-FokI CC carriers. Our findings lay down the basis for the potential of genetic screening to identify high risk of hypovitaminosis D in Chinese infants.

Original language	English
Pages (from-to)	63-72
Number of pages	10
Journal	Nutrition Bulletin
Volume	49
Issue number	1
Early online date	26 Dec 2023
DOIs	https://doi.org/10.1111/nbu.12656
Publication status	Published - Mar 2024

Bibliographical note

Copyright © 2023 The Authors. Nutrition Bulletin published by John Wiley & Sons Ltd on behalf of British Nutrition Foundation. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Keywords

25(OH)D
Chinese
GC gene
infants
VDR gene
Vitamin D-binding protein

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10.1111/nbu.12656Licence: CC BY-NC-ND 4.0

Nutrition Bulletin - 2023 - Tsang - Association of vitamin D‐binding protein polymorphisms and serum 25 OH D concentration
Copyright © 2023 The Authors. Nutrition Bulletin published by John Wiley & Sons Ltd on behalf of British Nutrition Foundation. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Final published version, 718 KBLicence: CC BY-NC-ND 4.0

Cite this

Tsang, H. W., Tung, K. T. S., Wong, R. S., Wong, S. Y., Tung, J. Y. L., Chua, G. T., Ho, M. H. K., Pang, C. P., Wong, W. H. S., Chan, G. C. F., Wong, I. C. K., & Ip, P. (2024). Association of vitamin D-binding protein polymorphisms and serum 25(OH)D concentration varies among Chinese healthy infants of different VDR-FokI genotypes: A multi-centre cross-sectional study. Nutrition Bulletin, 49(1), 63-72. https://doi.org/10.1111/nbu.12656

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title = "Association of vitamin D-binding protein polymorphisms and serum 25(OH)D concentration varies among Chinese healthy infants of different VDR-FokI genotypes: A multi-centre cross-sectional study",

abstract = "Hypovitaminosis D during infancy is associated with the development of chronic diseases and poor health later in life. While the effect of environmental factors on vitamin D concentration has been extensively explored, this study aimed to explore the effect of genetic factors on vitamin D concentration among Chinese infants. We conducted a multi-centre cross-sectional study in Hong Kong from July 2019 to May 2021. A candidate genetic approach was adopted to study four selected genetic variants of the vitamin D-binding protein (DBP) and vitamin D receptor (VDR) (rs4588, rs7041, rs2282679 and rs2228570) to examine their associations with measured serum 25(OH)D concentration. A total of 378 Chinese infants aged 2–12 months were recruited in this study. Peripheral blood samples were collected from the infants to measure serum 25(OH)D concentration and extract DNA. Results showed that rs7041T and rs2282679C were significantly associated with lower serum 25(OH)D concentration. Further analysis of the DBP variants revealed that the GC1F allele was significantly associated with lower 25(OH)D concentration and identified as the risk DBP isoform in infants. While our results revealed that there is no direct association between VDR-FokI genotype and serum 25(OH)D concentration, a VDR-FokI genotype-specific pattern was observed in the association between DBP isoforms and serum 25(OH)D concentration. Specifically, significant associations were observed in the DBP genotypes GC1F/F, GC1F/2 and GC1S/2 among VDR-FokI TT/TC carriers, but not in VDR-FokI CC carriers. Our findings lay down the basis for the potential of genetic screening to identify high risk of hypovitaminosis D in Chinese infants.",

keywords = "25(OH)D, Chinese, GC gene, infants, VDR gene, Vitamin D-binding protein",

author = "Tsang, {Hing Wai} and Tung, {Keith T. S.} and Wong, {Rosa S.} and Wong, {Siew Yan} and Tung, {Joanna Y. L.} and Chua, {Gilbert T.} and Ho, {Marco H. K.} and Pang, {Chi Pui} and Wong, {Wilfred H. S.} and Chan, {Godfrey C. F.} and Wong, {Ian C. K.} and Patrick Ip",

note = "Copyright {\textcopyright} 2023 The Authors. Nutrition Bulletin published by John Wiley & Sons Ltd on behalf of British Nutrition Foundation. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.",

year = "2024",

month = mar,

doi = "10.1111/nbu.12656",

language = "English",

volume = "49",

pages = "63--72",

journal = "Nutrition Bulletin",

issn = "1471-9827",

publisher = "Wiley",

number = "1",

}

Tsang, HW, Tung, KTS, Wong, RS, Wong, SY, Tung, JYL, Chua, GT, Ho, MHK, Pang, CP, Wong, WHS, Chan, GCF, Wong, ICK & Ip, P 2024, 'Association of vitamin D-binding protein polymorphisms and serum 25(OH)D concentration varies among Chinese healthy infants of different VDR-FokI genotypes: A multi-centre cross-sectional study', Nutrition Bulletin, vol. 49, no. 1, pp. 63-72. https://doi.org/10.1111/nbu.12656

Association of vitamin D-binding protein polymorphisms and serum 25(OH)D concentration varies among Chinese healthy infants of different VDR-FokI genotypes: A multi-centre cross-sectional study. / Tsang, Hing Wai; Tung, Keith T. S.; Wong, Rosa S. et al.
In: Nutrition Bulletin, Vol. 49, No. 1, 03.2024, p. 63-72.

Research output: Contribution to journal › Article › peer-review

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T1 - Association of vitamin D-binding protein polymorphisms and serum 25(OH)D concentration varies among Chinese healthy infants of different VDR-FokI genotypes: A multi-centre cross-sectional study

AU - Tsang, Hing Wai

AU - Tung, Keith T. S.

AU - Wong, Rosa S.

AU - Wong, Siew Yan

AU - Tung, Joanna Y. L.

AU - Chua, Gilbert T.

AU - Ho, Marco H. K.

AU - Pang, Chi Pui

AU - Wong, Wilfred H. S.

AU - Chan, Godfrey C. F.

AU - Wong, Ian C. K.

AU - Ip, Patrick

N1 - Copyright © 2023 The Authors. Nutrition Bulletin published by John Wiley & Sons Ltd on behalf of British Nutrition Foundation. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Y1 - 2024/3

N2 - Hypovitaminosis D during infancy is associated with the development of chronic diseases and poor health later in life. While the effect of environmental factors on vitamin D concentration has been extensively explored, this study aimed to explore the effect of genetic factors on vitamin D concentration among Chinese infants. We conducted a multi-centre cross-sectional study in Hong Kong from July 2019 to May 2021. A candidate genetic approach was adopted to study four selected genetic variants of the vitamin D-binding protein (DBP) and vitamin D receptor (VDR) (rs4588, rs7041, rs2282679 and rs2228570) to examine their associations with measured serum 25(OH)D concentration. A total of 378 Chinese infants aged 2–12 months were recruited in this study. Peripheral blood samples were collected from the infants to measure serum 25(OH)D concentration and extract DNA. Results showed that rs7041T and rs2282679C were significantly associated with lower serum 25(OH)D concentration. Further analysis of the DBP variants revealed that the GC1F allele was significantly associated with lower 25(OH)D concentration and identified as the risk DBP isoform in infants. While our results revealed that there is no direct association between VDR-FokI genotype and serum 25(OH)D concentration, a VDR-FokI genotype-specific pattern was observed in the association between DBP isoforms and serum 25(OH)D concentration. Specifically, significant associations were observed in the DBP genotypes GC1F/F, GC1F/2 and GC1S/2 among VDR-FokI TT/TC carriers, but not in VDR-FokI CC carriers. Our findings lay down the basis for the potential of genetic screening to identify high risk of hypovitaminosis D in Chinese infants.

AB - Hypovitaminosis D during infancy is associated with the development of chronic diseases and poor health later in life. While the effect of environmental factors on vitamin D concentration has been extensively explored, this study aimed to explore the effect of genetic factors on vitamin D concentration among Chinese infants. We conducted a multi-centre cross-sectional study in Hong Kong from July 2019 to May 2021. A candidate genetic approach was adopted to study four selected genetic variants of the vitamin D-binding protein (DBP) and vitamin D receptor (VDR) (rs4588, rs7041, rs2282679 and rs2228570) to examine their associations with measured serum 25(OH)D concentration. A total of 378 Chinese infants aged 2–12 months were recruited in this study. Peripheral blood samples were collected from the infants to measure serum 25(OH)D concentration and extract DNA. Results showed that rs7041T and rs2282679C were significantly associated with lower serum 25(OH)D concentration. Further analysis of the DBP variants revealed that the GC1F allele was significantly associated with lower 25(OH)D concentration and identified as the risk DBP isoform in infants. While our results revealed that there is no direct association between VDR-FokI genotype and serum 25(OH)D concentration, a VDR-FokI genotype-specific pattern was observed in the association between DBP isoforms and serum 25(OH)D concentration. Specifically, significant associations were observed in the DBP genotypes GC1F/F, GC1F/2 and GC1S/2 among VDR-FokI TT/TC carriers, but not in VDR-FokI CC carriers. Our findings lay down the basis for the potential of genetic screening to identify high risk of hypovitaminosis D in Chinese infants.

KW - 25(OH)D

KW - Chinese

KW - GC gene

KW - infants

KW - VDR gene

KW - Vitamin D-binding protein

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DO - 10.1111/nbu.12656

M3 - Article

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SN - 1471-9827

VL - 49

SP - 63

EP - 72

JO - Nutrition Bulletin

JF - Nutrition Bulletin

IS - 1

ER -

Association of vitamin D-binding protein polymorphisms and serum 25(OH)D concentration varies among Chinese healthy infants of different VDR-FokI genotypes: A multi-centre cross-sectional study

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Keywords

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