Attenuation of muscle atrophy in a murine model of cachexia by inhibition of the dsRNA-dependent protein kinase

Keyphrases

• Skeletal muscle 100%
• Protein Kinase 100%
• Attenuation 100%
• Cachexia 100%
• Protein Synthesis 100%
• Muscle Atrophy 100%
• Murine Model 100%
• Double-stranded RNA 100%
• PKR Inhibitor 100%
• Nontumor 66%
• Tumor Growth 66%
• Cancer Cachexia 66%
• Phosphorylation 33%
• Tumor 33%
• Autophosphorylation 33%
• Cancer Research 33%
• In Cancer 33%
• Atrophy 33%
• Protein Degradation 33%
• Proteasome Activity 33%
• EIF2 33%
• Protein Degradation Rates 33%
• Nuclear Accumulation 33%
• Muscle Mass 33%
• Nuclear factor-B 33%
• Tumor-bearing Animals 33%
• Myosin 33%
• Tumor-bearing Mice 33%
• Protein Kinase PKR 33%
• Muscle Wasting 33%
• Activity Level 33%

Biochemistry, Genetics and Molecular Biology

• Skeletal Muscle 100%
• Protein Kinases 100%
• Protein Biosynthesis 100%
• Double-Stranded RNA 100%
• Protein Catabolism 66%
• Tumor Progression 66%
• Proteasome 66%
• Autophosphorylation 33%
• Eukaryotic Initiation Factor 33%
• Complement Factor B 33%
• In Vitro Study 33%
• Protein Kinase R 33%
• Body Weight 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein Kinases 100%
• Cachexia 100%
• Muscle Atrophy 100%
• Neoplasm 75%
• Proteasome 50%
• Tumor Growth 50%
• Alternative Complement Pathway C3 C5 Convertase 25%
• Protein Kinase R 25%
• Initiation Factor 2 25%
• Nuclear Factor 25%
• Malignant Neoplasm 25%