AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation

Betul Cicek; Ahmet Hacimuftuoglu; Yesim Yeni; Mehmet Kuzucu; Sidika Genc; Ahmet Cetin; Emre Yavuz; Betul Danısman; Akin Levent; Kemal Volkan Ozdokur; Mecit Kantarcı; Anca Oana Docea; Vasileios Siokas; Konstantinos Tsarouhas; Michael D Coleman; Aristidis Tsatsakis; Ali Taghizadehghalehjoughi

doi:10.1016/j.etap.2024.104417

AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation

Betul Cicek
, Ahmet Hacimuftuoglu
, Yesim Yeni
, Mehmet Kuzucu
, Sidika Genc
, Ahmet Cetin
, Emre Yavuz
, Betul Danısman
, Akin Levent
, Kemal Volkan Ozdokur
, Mecit Kantarcı
, Anca Oana Docea
, Vasileios Siokas
, Konstantinos Tsarouhas
, Michael D Coleman
, Aristidis Tsatsakis
, Ali Taghizadehghalehjoughi

Department of Physiology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan 24100, Turkey.
Department of Medical Pharmacology, Faculty of Medicine, Ataturk University, Erzurum 25240, Turkey. Electronic address: [email protected].
Department of Medical Pharmacology, Faculty of Medicine, Malatya Turgut Ozal University, Malatya 44210, Turkey. Electronic address: [email protected].
Department of Biology, Faculty of Arts and Sciences, Erzincan Binali Yildirim University, Erzincan 24100, Turkey. Electronic address: [email protected].
Bilecik Şeyh Edebali University, Faculty of Medicine, Department of Medical Pharmacology, Bilecik 11230, Turkey.
Department of Biology, Faculty of Arts and Sciences, Erzincan Binali Yildirim University, Erzincan 24100, Turkey.
Department of Medical Services and Technicians, Çayirli Vocational School, Erzincan Binali Yildirim University, Erzincan, Turkey. Electronic address: [email protected].
Department of Biophysics, Faculty of Medicine, Ataturk University, Erzurum 25240, Turkey. Electronic address: [email protected].
Department of Radiology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan 24100, Turkey. Electronic address: [email protected].
Sciences Application and Research Center, Erzincan Binali Yildirim University, Erzincan 24100, Turkey. Electronic address: [email protected].
Department of Radiology, Faculty of Medicine, Ataturk University, Erzurum 25240, Turkey.
Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania. Electronic address: [email protected].
Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa 41100, Greece.
Department of Cardiology, University Hospital of Larissa, Larissa 41100, Greece.
Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion 71003, Greece. Electronic address: [email protected].
Bilecik Şeyh Edebali University, Faculty of Medicine, Department of Medical Pharmacology, Bilecik 11230, Turkey. Electronic address: [email protected].

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Abstract

The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO ) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously with 10 mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1β levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments. [Abstract copyright: Copyright © 2024 Elsevier B.V. All rights reserved.]

Original language	English
Article number	104417
Number of pages	11
Journal	Environmental Toxicology and Pharmacology
Volume	107
Early online date	15 Mar 2024
DOIs	https://doi.org/10.1016/j.etap.2024.104417
Publication status	Published - Apr 2024

Bibliographical note

Copyright © 2024, Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/

Funding

The present study was partly funded by the European Union's Horizon Europe framework program project ‘European Partnership for the Assessment of Risks from Chemicals (PARC).

Funders
European Union's Horizon Europe framework program
Pakistan Agricultural Research Council

Keywords

D2R
D1R
Arsenic
Cynara scolymus
AuNPs
Neurotoxicity

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10.1016/j.etap.2024.104417

AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balbc mice through D1R and D2R activation
Copyright © 2024, Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 1.41 MBLicence: CC BY-NC-ND 4.0

Cite this

Cicek, B., Hacimuftuoglu, A., Yeni, Y., Kuzucu, M., Genc, S., Cetin, A., Yavuz, E., Danısman, B., Levent, A., Ozdokur, K. V., Kantarcı, M., Docea, A. O., Siokas, V., Tsarouhas, K., Coleman, M. D., Tsatsakis, A., & Taghizadehghalehjoughi, A. (2024). AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation. Environmental Toxicology and Pharmacology, 107, Article 104417. https://doi.org/10.1016/j.etap.2024.104417

@article{7f98a62ad05047c7b3b40f951f56dc7d,

title = "AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation",

abstract = "The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO ) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously with 10 mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1β levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments. [Abstract copyright: Copyright {\textcopyright} 2024 Elsevier B.V. All rights reserved.]",

keywords = "D2R, D1R, Arsenic, Cynara scolymus, AuNPs, Neurotoxicity",

author = "Betul Cicek and Ahmet Hacimuftuoglu and Yesim Yeni and Mehmet Kuzucu and Sidika Genc and Ahmet Cetin and Emre Yavuz and Betul Danısman and Akin Levent and Ozdokur, \{Kemal Volkan\} and Mecit Kantarcı and Docea, \{Anca Oana\} and Vasileios Siokas and Konstantinos Tsarouhas and Coleman, \{Michael D\} and Aristidis Tsatsakis and Ali Taghizadehghalehjoughi",

note = "Copyright {\textcopyright} 2024, Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/",

year = "2024",

month = apr,

doi = "10.1016/j.etap.2024.104417",

language = "English",

volume = "107",

journal = "Environmental Toxicology and Pharmacology",

issn = "1382-6689",

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Cicek, B, Hacimuftuoglu, A, Yeni, Y, Kuzucu, M, Genc, S, Cetin, A, Yavuz, E, Danısman, B, Levent, A, Ozdokur, KV, Kantarcı, M, Docea, AO, Siokas, V, Tsarouhas, K, Coleman, MD, Tsatsakis, A & Taghizadehghalehjoughi, A 2024, 'AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation', Environmental Toxicology and Pharmacology, vol. 107, 104417. https://doi.org/10.1016/j.etap.2024.104417

TY - JOUR

T1 - AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation

AU - Cicek, Betul

AU - Hacimuftuoglu, Ahmet

AU - Yeni, Yesim

AU - Kuzucu, Mehmet

AU - Genc, Sidika

AU - Cetin, Ahmet

AU - Yavuz, Emre

AU - Danısman, Betul

AU - Levent, Akin

AU - Ozdokur, Kemal Volkan

AU - Kantarcı, Mecit

AU - Docea, Anca Oana

AU - Siokas, Vasileios

AU - Tsarouhas, Konstantinos

AU - Coleman, Michael D

AU - Tsatsakis, Aristidis

AU - Taghizadehghalehjoughi, Ali

N1 - Copyright © 2024, Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/

PY - 2024/4

Y1 - 2024/4

N2 - The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO ) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously with 10 mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1β levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments. [Abstract copyright: Copyright © 2024 Elsevier B.V. All rights reserved.]

AB - The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO ) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously with 10 mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1β levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments. [Abstract copyright: Copyright © 2024 Elsevier B.V. All rights reserved.]

KW - D2R

KW - D1R

KW - Arsenic

KW - Cynara scolymus

KW - AuNPs

KW - Neurotoxicity

UR - https://www.sciencedirect.com/science/article/abs/pii/S1382668924000577?via%3Dihub

UR - https://www.scopus.com/pages/publications/85189019729

U2 - 10.1016/j.etap.2024.104417

DO - 10.1016/j.etap.2024.104417

M3 - Article

C2 - 38493879

SN - 1382-6689

VL - 107

JO - Environmental Toxicology and Pharmacology

JF - Environmental Toxicology and Pharmacology

M1 - 104417

ER -

AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation

Abstract

Bibliographical note

Funding

Keywords

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