Beer, wine consumption, and 10-year CVD incidence: the ATTICA study

Demosthenes B. Panagiotakos, Georgia-maria Kouli, Emmanuela Magriplis, Ioannis Kyrou, Ekavi N. Georgousopoulou, Christina Chrysohoou, Constantine Tsigos, Dimitrios Tousoulis, Christos Pitsavos

Research output: Contribution to journalArticle

Abstract

Background/objectives Low/moderate alcohol consumption seems to be protective against cardiovascular disease (CVD). This study aimed to investigate the association of wine/beer consumption with the 10-year CVD incidence. Subjects/methods During 2001–2002, 3042 CVD-free adults consented to participate in the ATTICA study; of them 2583 completed the 10-year follow-up (85% participation rate), but precise information about fatal/nonfatal CVD incidence (myocardial infarction, angina pectoris, cardiac ischemia, heart failure, chronic arrhythmias, and stroke) was available in 2020 participants (overall retention rate 66%). Alcohol/ethanol intake and the alcoholic beverages consumed were assessed; participants were categorized into three groups (no use; ≤1 glass/week; >1 glass/week). Results Alcohol drinking was reported by 56% of the participants who did not develop a CVD event and 49% of those who had (p = 0.04); whereas ethanol intake was 14 ± 16 g among those who did not had an event vs. 21 ± 18 g among those who had a CVD event (p < 0.001). A strong inverse and similar association between low wine/beer intake (≤1 glass/week) and the risk of developing CVD was observed [HR: 0.40, 95% confidence interval (CI): 0.17–0.98; and HR: 0.43, 95% CI: 0.20–0.93, respectively], as compared to abstention. No significant association was found in participants exceeding drinking 1 glass/week compared with abstainers. Compared to <2 g/day ethanol intake, participants who reported 2–10, 10–20, and >20 g/day had CVD-risk HRs (95% CI) of 0.60 (0.40–0.98), 1.22 (0.60–1.14), and 1.81 (0.70–4.61), respectively. Conclusions This study revealed similar results of low wine/beer consumption against CVD incidence, mainly due to its implication on low-grade chronic inflammation.
Original languageEnglish
JournalEuropean Journal of Clinical Nutrition
Early online date30 Aug 2018
DOIs
Publication statusE-pub ahead of print - 30 Aug 2018

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Wine
Cohort Studies
Cardiovascular Diseases
Glass
Incidence
Ethanol
Alcoholic Beverages
Angina Pectoris
Alcohol Drinking
Drinking
Cardiac Arrhythmias
Ischemia
Heart Failure
Stroke
Myocardial Infarction
Alcohols
Inflammation

Cite this

Panagiotakos, D. B., Kouli, G., Magriplis, E., Kyrou, I., Georgousopoulou, E. N., Chrysohoou, C., ... Pitsavos, C. (2018). Beer, wine consumption, and 10-year CVD incidence: the ATTICA study. European Journal of Clinical Nutrition. https://doi.org/10.1038/s41430-018-0296-6
Panagiotakos, Demosthenes B. ; Kouli, Georgia-maria ; Magriplis, Emmanuela ; Kyrou, Ioannis ; Georgousopoulou, Ekavi N. ; Chrysohoou, Christina ; Tsigos, Constantine ; Tousoulis, Dimitrios ; Pitsavos, Christos. / Beer, wine consumption, and 10-year CVD incidence: the ATTICA study. In: European Journal of Clinical Nutrition. 2018.
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abstract = "Background/objectives Low/moderate alcohol consumption seems to be protective against cardiovascular disease (CVD). This study aimed to investigate the association of wine/beer consumption with the 10-year CVD incidence. Subjects/methods During 2001–2002, 3042 CVD-free adults consented to participate in the ATTICA study; of them 2583 completed the 10-year follow-up (85{\%} participation rate), but precise information about fatal/nonfatal CVD incidence (myocardial infarction, angina pectoris, cardiac ischemia, heart failure, chronic arrhythmias, and stroke) was available in 2020 participants (overall retention rate 66{\%}). Alcohol/ethanol intake and the alcoholic beverages consumed were assessed; participants were categorized into three groups (no use; ≤1 glass/week; >1 glass/week). Results Alcohol drinking was reported by 56{\%} of the participants who did not develop a CVD event and 49{\%} of those who had (p = 0.04); whereas ethanol intake was 14 ± 16 g among those who did not had an event vs. 21 ± 18 g among those who had a CVD event (p < 0.001). A strong inverse and similar association between low wine/beer intake (≤1 glass/week) and the risk of developing CVD was observed [HR: 0.40, 95{\%} confidence interval (CI): 0.17–0.98; and HR: 0.43, 95{\%} CI: 0.20–0.93, respectively], as compared to abstention. No significant association was found in participants exceeding drinking 1 glass/week compared with abstainers. Compared to <2 g/day ethanol intake, participants who reported 2–10, 10–20, and >20 g/day had CVD-risk HRs (95{\%} CI) of 0.60 (0.40–0.98), 1.22 (0.60–1.14), and 1.81 (0.70–4.61), respectively. Conclusions This study revealed similar results of low wine/beer consumption against CVD incidence, mainly due to its implication on low-grade chronic inflammation.",
author = "Panagiotakos, {Demosthenes B.} and Georgia-maria Kouli and Emmanuela Magriplis and Ioannis Kyrou and Georgousopoulou, {Ekavi N.} and Christina Chrysohoou and Constantine Tsigos and Dimitrios Tousoulis and Christos Pitsavos",
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Panagiotakos, DB, Kouli, G, Magriplis, E, Kyrou, I, Georgousopoulou, EN, Chrysohoou, C, Tsigos, C, Tousoulis, D & Pitsavos, C 2018, 'Beer, wine consumption, and 10-year CVD incidence: the ATTICA study', European Journal of Clinical Nutrition. https://doi.org/10.1038/s41430-018-0296-6

Beer, wine consumption, and 10-year CVD incidence: the ATTICA study. / Panagiotakos, Demosthenes B.; Kouli, Georgia-maria; Magriplis, Emmanuela; Kyrou, Ioannis; Georgousopoulou, Ekavi N.; Chrysohoou, Christina; Tsigos, Constantine; Tousoulis, Dimitrios; Pitsavos, Christos.

In: European Journal of Clinical Nutrition, 30.08.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Beer, wine consumption, and 10-year CVD incidence: the ATTICA study

AU - Panagiotakos, Demosthenes B.

AU - Kouli, Georgia-maria

AU - Magriplis, Emmanuela

AU - Kyrou, Ioannis

AU - Georgousopoulou, Ekavi N.

AU - Chrysohoou, Christina

AU - Tsigos, Constantine

AU - Tousoulis, Dimitrios

AU - Pitsavos, Christos

PY - 2018/8/30

Y1 - 2018/8/30

N2 - Background/objectives Low/moderate alcohol consumption seems to be protective against cardiovascular disease (CVD). This study aimed to investigate the association of wine/beer consumption with the 10-year CVD incidence. Subjects/methods During 2001–2002, 3042 CVD-free adults consented to participate in the ATTICA study; of them 2583 completed the 10-year follow-up (85% participation rate), but precise information about fatal/nonfatal CVD incidence (myocardial infarction, angina pectoris, cardiac ischemia, heart failure, chronic arrhythmias, and stroke) was available in 2020 participants (overall retention rate 66%). Alcohol/ethanol intake and the alcoholic beverages consumed were assessed; participants were categorized into three groups (no use; ≤1 glass/week; >1 glass/week). Results Alcohol drinking was reported by 56% of the participants who did not develop a CVD event and 49% of those who had (p = 0.04); whereas ethanol intake was 14 ± 16 g among those who did not had an event vs. 21 ± 18 g among those who had a CVD event (p < 0.001). A strong inverse and similar association between low wine/beer intake (≤1 glass/week) and the risk of developing CVD was observed [HR: 0.40, 95% confidence interval (CI): 0.17–0.98; and HR: 0.43, 95% CI: 0.20–0.93, respectively], as compared to abstention. No significant association was found in participants exceeding drinking 1 glass/week compared with abstainers. Compared to <2 g/day ethanol intake, participants who reported 2–10, 10–20, and >20 g/day had CVD-risk HRs (95% CI) of 0.60 (0.40–0.98), 1.22 (0.60–1.14), and 1.81 (0.70–4.61), respectively. Conclusions This study revealed similar results of low wine/beer consumption against CVD incidence, mainly due to its implication on low-grade chronic inflammation.

AB - Background/objectives Low/moderate alcohol consumption seems to be protective against cardiovascular disease (CVD). This study aimed to investigate the association of wine/beer consumption with the 10-year CVD incidence. Subjects/methods During 2001–2002, 3042 CVD-free adults consented to participate in the ATTICA study; of them 2583 completed the 10-year follow-up (85% participation rate), but precise information about fatal/nonfatal CVD incidence (myocardial infarction, angina pectoris, cardiac ischemia, heart failure, chronic arrhythmias, and stroke) was available in 2020 participants (overall retention rate 66%). Alcohol/ethanol intake and the alcoholic beverages consumed were assessed; participants were categorized into three groups (no use; ≤1 glass/week; >1 glass/week). Results Alcohol drinking was reported by 56% of the participants who did not develop a CVD event and 49% of those who had (p = 0.04); whereas ethanol intake was 14 ± 16 g among those who did not had an event vs. 21 ± 18 g among those who had a CVD event (p < 0.001). A strong inverse and similar association between low wine/beer intake (≤1 glass/week) and the risk of developing CVD was observed [HR: 0.40, 95% confidence interval (CI): 0.17–0.98; and HR: 0.43, 95% CI: 0.20–0.93, respectively], as compared to abstention. No significant association was found in participants exceeding drinking 1 glass/week compared with abstainers. Compared to <2 g/day ethanol intake, participants who reported 2–10, 10–20, and >20 g/day had CVD-risk HRs (95% CI) of 0.60 (0.40–0.98), 1.22 (0.60–1.14), and 1.81 (0.70–4.61), respectively. Conclusions This study revealed similar results of low wine/beer consumption against CVD incidence, mainly due to its implication on low-grade chronic inflammation.

UR - http://www.nature.com/articles/s41430-018-0296-6

U2 - 10.1038/s41430-018-0296-6

DO - 10.1038/s41430-018-0296-6

M3 - Article

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

ER -