Behavioral and molecular genetics of reading-related AM and FM detection thresholds

Matthew Bruni, Judy F. Flax, Steven Buyske, Amber D. Shindhelm, Caroline Witton, Linda M. Brzustowicz, Christopher W. Bartlett*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h2 = 0.20) and FM (h2 = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 %) and FM (10p, PPL = 32 %; 20q, PPL = 65 %). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.
Original languageEnglish
Pages (from-to)193–201
Number of pages9
JournalBehavior Genetics
Volume47
Issue number2
Early online date9 Nov 2016
DOIs
Publication statusPublished - Mar 2017

Fingerprint

Behavioral Genetics
molecular genetics
Reading
Molecular Biology
detection limit
linkage (genetics)
heritability
Psychoacoustics
Auditory Threshold
extended families
loci
detection

Bibliographical note

The final publication is available at Springer via http://dx.doi.org/10.1007/s10519-016-9821-3

Keywords

  • dynamic auditory sensitivity
  • AM sensitivity
  • FM sensitivity
  • reading
  • language
  • heritability

Cite this

Bruni, M., Flax, J. F., Buyske, S., Shindhelm, A. D., Witton, C., Brzustowicz, L. M., & Bartlett, C. W. (2017). Behavioral and molecular genetics of reading-related AM and FM detection thresholds. Behavior Genetics, 47(2), 193–201. https://doi.org/10.1007/s10519-016-9821-3
Bruni, Matthew ; Flax, Judy F. ; Buyske, Steven ; Shindhelm, Amber D. ; Witton, Caroline ; Brzustowicz, Linda M. ; Bartlett, Christopher W. / Behavioral and molecular genetics of reading-related AM and FM detection thresholds. In: Behavior Genetics. 2017 ; Vol. 47, No. 2. pp. 193–201.
@article{5b5115af37f74fa38816c7cf7acac145,
title = "Behavioral and molecular genetics of reading-related AM and FM detection thresholds",
abstract = "Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h2 = 0.20) and FM (h2 = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 {\%}) and FM (10p, PPL = 32 {\%}; 20q, PPL = 65 {\%}). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.",
keywords = "dynamic auditory sensitivity, AM sensitivity, FM sensitivity, reading, language, heritability",
author = "Matthew Bruni and Flax, {Judy F.} and Steven Buyske and Shindhelm, {Amber D.} and Caroline Witton and Brzustowicz, {Linda M.} and Bartlett, {Christopher W.}",
note = "The final publication is available at Springer via http://dx.doi.org/10.1007/s10519-016-9821-3",
year = "2017",
month = "3",
doi = "10.1007/s10519-016-9821-3",
language = "English",
volume = "47",
pages = "193–201",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer",
number = "2",

}

Bruni, M, Flax, JF, Buyske, S, Shindhelm, AD, Witton, C, Brzustowicz, LM & Bartlett, CW 2017, 'Behavioral and molecular genetics of reading-related AM and FM detection thresholds', Behavior Genetics, vol. 47, no. 2, pp. 193–201. https://doi.org/10.1007/s10519-016-9821-3

Behavioral and molecular genetics of reading-related AM and FM detection thresholds. / Bruni, Matthew; Flax, Judy F.; Buyske, Steven; Shindhelm, Amber D.; Witton, Caroline; Brzustowicz, Linda M.; Bartlett, Christopher W.

In: Behavior Genetics, Vol. 47, No. 2, 03.2017, p. 193–201.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Behavioral and molecular genetics of reading-related AM and FM detection thresholds

AU - Bruni, Matthew

AU - Flax, Judy F.

AU - Buyske, Steven

AU - Shindhelm, Amber D.

AU - Witton, Caroline

AU - Brzustowicz, Linda M.

AU - Bartlett, Christopher W.

N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/s10519-016-9821-3

PY - 2017/3

Y1 - 2017/3

N2 - Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h2 = 0.20) and FM (h2 = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 %) and FM (10p, PPL = 32 %; 20q, PPL = 65 %). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.

AB - Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h2 = 0.20) and FM (h2 = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 %) and FM (10p, PPL = 32 %; 20q, PPL = 65 %). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.

KW - dynamic auditory sensitivity

KW - AM sensitivity

KW - FM sensitivity

KW - reading

KW - language

KW - heritability

UR - http://link.springer.com/article/10.1007%2Fs10519-016-9821-3

UR - http://www.scopus.com/inward/record.url?scp=84994406638&partnerID=8YFLogxK

U2 - 10.1007/s10519-016-9821-3

DO - 10.1007/s10519-016-9821-3

M3 - Article

AN - SCOPUS:84994406638

VL - 47

SP - 193

EP - 201

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 2

ER -