Behavioral and molecular genetics of reading-related AM and FM detection thresholds

Matthew Bruni; Judy F. Flax; Steven Buyske; Amber D. Shindhelm; Caroline Witton; Linda M. Brzustowicz; Christopher W. Bartlett

doi:10.1007/s10519-016-9821-3

Behavioral and molecular genetics of reading-related AM and FM detection thresholds

Matthew Bruni, Judy F. Flax, Steven Buyske, Amber D. Shindhelm, Caroline Witton, Linda M. Brzustowicz, Christopher W. Bartlett^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h² = 0.20) and FM (h² = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 %) and FM (10p, PPL = 32 %; 20q, PPL = 65 %). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.

Original language	English
Pages (from-to)	193–201
Number of pages	9
Journal	Behavior Genetics
Volume	47
Issue number	2
Early online date	9 Nov 2016
DOIs	https://doi.org/10.1007/s10519-016-9821-3
Publication status	Published - Mar 2017

Bibliographical note

The final publication is available at Springer via http://dx.doi.org/10.1007/s10519-016-9821-3

Keywords

dynamic auditory sensitivity
AM sensitivity
FM sensitivity
reading
language
heritability

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10.1007/s10519-016-9821-3

Behavioral & molecular genetics of reading-related AM&FM detection thresholds
The final publication is available at Springer via http://dx.doi.org/10.1007/s10519-016-9821-3
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title = "Behavioral and molecular genetics of reading-related AM and FM detection thresholds",

abstract = "Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h2 = 0.20) and FM (h2 = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 %) and FM (10p, PPL = 32 %; 20q, PPL = 65 %). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.",

keywords = "dynamic auditory sensitivity, AM sensitivity, FM sensitivity, reading, language, heritability",

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AU - Bruni, Matthew

AU - Flax, Judy F.

AU - Buyske, Steven

AU - Shindhelm, Amber D.

AU - Witton, Caroline

AU - Brzustowicz, Linda M.

AU - Bartlett, Christopher W.

N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/s10519-016-9821-3

PY - 2017/3

Y1 - 2017/3

N2 - Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h2 = 0.20) and FM (h2 = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 %) and FM (10p, PPL = 32 %; 20q, PPL = 65 %). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.

AB - Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h2 = 0.20) and FM (h2 = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 %) and FM (10p, PPL = 32 %; 20q, PPL = 65 %). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.

KW - dynamic auditory sensitivity

KW - AM sensitivity

KW - FM sensitivity

KW - reading

KW - language

KW - heritability

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JO - Behavior Genetics

JF - Behavior Genetics

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ER -

Behavioral and molecular genetics of reading-related AM and FM detection thresholds

Abstract

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Keywords

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